Opiate Overdose

10/06/2023 - "This Viewpoint advocates for improved strategies to measure naloxone distribution and evaluate how effectively naloxone reaches people most likely to experience or witness an opioid overdose."
12/19/2017 - "Naloxone is effective for reversing opioid overdose, but optimal strategies for out-of-hospital use are uncertain. "
01/01/2023 - "A hands-on naloxone training is beneficial for training rural clinicians and staff to respond to opioid overdose. "
01/01/2022 - "Summary of Scope: This article explores 5 areas (many illustrations UK-based where the author works): firstly, the need for strong science; secondly, our improved understanding of opioid overdose and deaths; thirdly, the search for greater impact from our policies and interventions; fourthly, developing better forms of naloxone; and fifthly, examining the challenges still to be addressed. "
11/15/2018 - "The implementation of an outpatient naloxone prescribing policy at a large academic medical center created a streamlined approach for the interprofessional healthcare team to use in providing naloxone education and improved naloxone access to patients at high risk for opioid overdose."

01/01/2019 - "Because of its sustained effects, MCAM might provide more effective rescue from and protection against the fatal respiratory-depressant effects of opioids, thereby improving treatment of opioid overdose."
03/01/2022 - "This study may aid in the identification of potential areas for improvement in the prevention of opioid overdose and opioid-related mortality among veterans. "
11/29/2023 - "This study demonstrates that data-based opioid risk review can reduce opioid-related SAEs, opioid overdoses, and suicide-related events in the 6 months post-review. "
11/01/2023 - "This study aims to assess the association of community social vulnerability and community prescription opioid availability with individual non-fatal or fatal opioid overdose. "
01/01/2023 - "The objective of this study was to describe our efforts to combat opioid overdose, prevent deaths, and examine and identify opioid use and predictors of opioid use through factors including age, sex assigned at birth, and ethnicity among the incarcerated population within the Los Angeles County jail system. "

09/01/2023 - "Additional states should seek to enable pharmacists to prescribe buprenorphine to increase access to a proven beneficial treatment and help reduce fatal opioid overdoses."
09/05/2023 - "Our findings suggest that telehealth-initiated buprenorphine treatment is associated with reduced opioid overdose rate and improved patient engagement. "
02/03/2015 - "We aimed to evaluate the efficacy of buprenorphine in reversal of opioid-overdose syndrome in dependent-rats. "
10/17/2023 - "Our study aim was to estimate the impact of buprenorphine diversion on opioid overdose using an agent-based model calibrated to North Carolina. "
10/11/2023 - "Studies show that despite rising opioid overdoses, buprenorphine prescription increases have been slow to rise and are particularly absent in rural communities. "

11/26/2020 - "If the RAPIDS intervention is found to be effective, its brief MI and fentanyl test strip training components could be easily incorporated into existing community-based overdose prevention programming to help reduce the rates of fentanyl-related opioid overdose. "
09/07/2022 - "We sought to adapt a behavioral intervention to prevent opioid overdose (repeated-dose behavioral intervention to reduce opioid overdose [REBOOT]) that had been successfully piloted in San Francisco, California, United States, to the setting of Boston, Massachusetts, United States, and the era of fentanyl for a full efficacy trial. "
09/07/2022 - "It's All Fentanyl." Adaptation of an Opioid Overdose Prevention Counseling Approach to Address Fentanyl Overdose: Formative Study."
12/01/2021 - "This study reports on medically treated opioid overdose trends in a state with rapid fentanyl spread. "
01/01/2021 - "Like previous studies, our data indicate the high prevalence of fentanyl exposure and low perception of fentanyl-related risk among individuals with OUD, respectively, suggesting that opioid overdose harm reduction efforts may need to focus more on drug users' understanding of risks related to fentanyl use and adulteration of drugs. "

01/01/2022 - "We utilize location data for methadone clinics and FQHCs, and opioid overdose death rates at the county level from 2019 for the study analysis. "
01/01/2022 - "In this study, we examine the relationship between access to methadone clinics and opioid overdose death rates at the county level and compare access to treatment through Federally Qualified Health Centers (FQHCs) if methadone provision was to expand in Georgia. "
01/01/2021 - "We will: (1) Perform a longitudinal treatment outcome study among incarcerated individuals with OUD who receive NTX, BUP, methadone, or no MOUD in jail to examine postrelease MOUD initiation, engagement, and retention, as well as fatal and nonfatal opioid overdose and recidivism; (2) Conduct an implementation study to understand systemic and contextual factors that facilitate and impede delivery of MOUDs in jail and community care coordination, and strategies that optimize MOUD delivery in jail and for coordinating care with community partners; (3) Calculate the cost to the correctional system of implementing MOUD in jail, and conduct an economic evaluation from state policy-maker and societal perspectives to compare the value of MOUD prior to release from jail to no MOUD among matched controls. "
05/01/2022 - "Results Methadone prescriptions, racial demographics, and poverty were found to significantly correspond to opioid overdose death rates (p < 0.05). "
01/01/2022 - "Additionally, 7 out of the 9 counties with the highest opioid overdose death rates have no methadone clinic accessible within a 15-minute drive time, though all those counties have easier access to FQHCs. "

12/31/2021 - "To address this problem, we have designed a wearable, on-demand system that comprises a safe, compact, non-invasive device which can monitor, and effectively deliver an antidote without human intervention, and report the opioid overdose event. "
12/31/2021 - "Thus, many lives are lost because: (1) an opioid overdose is not anticipated (i.e., monitored/detected), and (2) antidote is either not present, and/or not administered within the critical frame of effectiveness. "
01/01/2020 - "Currently, ≤5% of bystanders witnessing an opioid overdose (OD) in the US administer antidote to the victim. "
01/01/2019 - "Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose."
01/01/2019 - "Automatic antidote delivery device for opioid overdose."

07/01/2022 - "This study sought to evaluate the association between key contextual factors and experiencing a non-fatal opioid overdose among people who use heroin in Washington Heights, New York City. "
12/01/2019 - "Prior studies in heroin use disorder reported low rates (10%) of suicidal intention with non-fatal opioid overdose but did not assess dimensional ratings of suicidal ideation. "
10/01/2017 - "Pharmaceutical opioid overdose deaths increased during the study period (from 21.9 per million population in 2001-36.2), and in 2012 they occurred at 2.5 times the incident rate of heroin overdose deaths. "
01/01/2017 - "This study documents the differences in trends in prescription opioid overdose-related (POD) and heroin overdose-related (HOD) hospitalizations. "
07/01/2015 - "This study describes trends and demographic shifts of heroin overdoses and heroin-related fatalities in Wisconsin and contrasts these with prescription opioid overdoses. "

02/01/2022 - "Medication-assisted treatment for opiate use disorder has demonstrated efficacy in reducing opiate overdoses and all-cause mortality and improving multiple other patient-centered outcomes. "
01/01/2001 - "That was demonstrated in experimental and morphological studies of opiate addicts who died after opiate overdose. "
10/23/2020 - "Receipt of OAT was associated with fewer opiate-positive urine drug screens (P = .003), lower human immunodeficiency virus risk-taking behavior scores (P < .001), and lower rates of opioid overdose (P = .04). "
10/01/2020 - "Millions of Americans suffer from opiate use disorder, and over 100 die every day from opioid overdoses. "
11/01/2018 - "Opiate use disorder is a common condition in healthcare services in Ireland, where over 200 opiate overdose deaths occur annually. "

11/01/2011 - "Naltrexone may be useful for the treatment of opioid overdose in cats."
09/01/2019 - "Manuscripts meeting criteria were examined for citations meriting further review, leading to the addition of 30 manuscripts Conclusions: Here, we review the pharmacology of naltrexone as it relates to OUD, its history of use, and highlight recent studies and new approaches for use of the drug as MAT including its potential initiation after ED visit for opioid overdose."
01/01/2021 - "Evaluation of Opioid Overdose Reports in Patients Treated with Extended-Release Naltrexone: Postmarketing Data from 2006 to 2018."
10/01/2012 - "The use of implant naltrexone can reduce all-cause mortality and opiate overdose during the first 4 months following treatment compared with patients treated with oral naltrexone."
10/01/2012 - "Differences in initial mortality rates following treatment were associated predominantly with high rates of opiate overdoses in oral naltrexone patients during the first 4 months following treatment (17.22 ptpy compared with 0.67 ptpy in implant naltrexone patients) (P < 0.0001). "

02/01/1993 - "Nalmefene is effective in the reversal of opiate overdose and appears to be safe in the management of patients with altered sensorium."
12/01/2023 - "Inherent to this abbreviated approval process, intranasal nalmefene was not studied in patients currently suffering opioid overdose. "
07/27/2023 - "Pharmacokinetic Properties of an FDA-approved Intranasal Nalmefene Formulation for the Treatment of Opioid Overdose."
01/01/2022 - "Nalmefene returns for reversal of opioid overdose."
11/01/2019 - "injection of nalmefene (1.5 mg) previously approved to treat opioid overdose. "

01/01/2021 - "The US Department of Health and Human Services' 5-point strategy to combat the opioid overdose public health crisis includes improved pain management. "
03/19/2019 - "Outcomes of several studies provide substantial evidence that pharmacists can make an impact through appropriate pain management, use of PDMPs, opioid overdose prevention training, and medication reviews and counseling, among other interventions."
01/01/2022 - "A crisis in pain management persists, as does the epidemic of opioid overdose deaths, addiction, and diversion. "
09/15/2020 - "These characteristics could be addressed to optimize individuals' pain management and help address the opioid overdose epidemic."
01/01/2020 - "The severity and complexity of the problems of pain management and opioid overdose have led to large-scale intervention by policymakers. "

11/16/2020 - "Objective Structured Clinical Examination Skill Station Is Effective for Assessing Acute Opioid Overdose Resuscitation."
01/01/2022 - "Resuscitation simulation among people who are likely to witness opioid overdose: Experiences from the SOONER Trial."
12/01/2018 - "Despite rising rates of opioid overdose in the United States, few studies have examined the frequency of non-fatal overdose events or mortality outcomes following resuscitation. "
02/01/2022 - "Our results underscore the role that tolerance and concomitant drug exposure play in the precipitation and resuscitation of management of opioid overdose."
11/16/2020 - "Discussion Based on early medical student feedback (n=10), this OSCE skill station provides a promising competency-based assessment for opioid overdose resuscitation outside of the hospital setting. "

01/01/2021 - "Can Extended-release Injectable Medications Help Curb United States and Canada's Opioid Overdose Epidemic?"
01/01/2021 - "This commentary discusses the potential fit of different extended-release injectable MOUD to circumvent limitations of oral formulations, and thereby improve linkage and retention in care of high-risk populations, such as opioid-overdose survivors."
01/01/2020 - "The present meta-analysis demonstrated that intranasal naloxone is as effective as injectable naloxone in the pre-hospital management of opioid overdose complications. "
06/01/2023 - "Rapid induction onto extended-release injectable buprenorphine following opioid overdose: A case series."
01/01/2022 - "Zimhi - a higher-dose injectable naloxone for opioid overdose."

12/15/2014 - "Intranasal administration of naloxone appears to be effective in treatment of opioid overdose when i.v. administration is impossible or undesirable."
03/01/2018 - "For dampening microglial/macrophage activation, we chose intranasal administration of naloxone, a drug that is already in clinical use for opioid overdose and is known to decrease microglia/macrophage activation. "
01/01/2020 - "The present systematic review and meta-analysis aims to perform an extensive search in databases to compare the efficacy of the intranasal administration of naloxone with its intramuscular/intravenous administration in the pre-hospital management of opioid overdose. "
07/01/2023 - "Naloxone for opioid overdose treatment can be administered by intravenous injection, intramuscular injection, or intranasal administration. "
04/15/2020 - "People who use opioids recognise three distinct and interconnected outcomes that may follow a successful opioid overdose reversal after intramuscular or intranasal administration of naloxone. "

11/01/2021 - "Whereas some pharmacists intended to become more familiarized with the standing order, others did not intend to actively identify patients who were at risk of an opioid overdose. "
03/01/2016 - "Evidence suggests that naloxone administration by laypersons, pursuant to physician prescription or standing order, is safe and effective for reversal of opioid overdose. "
01/01/2022 - ": To assess the change in the trends of fatal opioid overdose rates following the expansion of the Naloxone Standing Order (eNSO) and its association with the social determinants of health (SDoH).Methods: Data on overdose deaths and SDoH from 2015-2019 was collected and analyzed using interrupted time series and multivariate Poisson regression models to study the change in trends and the associations.Results"
01/01/2023 - "Naloxone standing orders are strongly related to fatal synthetic opioid overdose reduction. "
01/01/2022 - "Expanding naloxone distribution and administration and ensuring proper education about standing orders for naloxone administration are important tools for addressing opioid overdose mortality."