Peptidyl-Prolyl Isomerase F

A member of the cyclophilins family of isomerases which plays a role in the regulation of the permeability transition pore in mitochondria. The protein has the alias name cyclophilin D which is also the alias name for the related protein Peptidyl-Prolyl Isomerase D.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Molkentin, Jeffery D: 2 articles (04/2011 - 04/2008)
2.	Argaud, Laurent: 1 article (11/2022)
3.	Bidaux, Gabriel: 1 article (11/2022)
4.	Bolbos, Radu: 1 article (11/2022)
5.	Cour, Martin: 1 article (11/2022)
6.	Jahandiez, Vincent: 1 article (11/2022)
7.	Ovize, Michel: 1 article (11/2022)
8.	Pillot, Bruno: 1 article (11/2022)
9.	Stevic, Neven: 1 article (11/2022)
10.	Wiart, Marlene: 1 article (11/2022)

Related Diseases

1.	Necrosis 03/15/2016 - "In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria." 04/01/2008 - "Here we show that deletion of the gene encoding cyclophilin D (Ppif) rendered mitochondria largely insensitive to the calcium overload-induced swelling associated with a defective sarcolemma, thus reducing myofiber necrosis in two distinct models of muscular dystrophy. " 12/28/2019 - "Here we discovered that MTB infection induced programmed necrosis in human macrophages, causing mitochondrial cyclophilin-D (CypD)-p53-adenine nucleotide translocator type 1 association, mitochondrial depolarization and lactate dehydrogenase medium release. " 04/11/2011 - "Here, through a genetic analysis, we show that necroptosis in caspase 8-deficient T cells is related neither to the programmed necrosis as defined by the requirement for mitochondrial cyclophilin D nor to autophagy as defined by the requirement for autophagy-related protein 7. Rather, survival of caspase 8-defective T cells can be completely rescued by loss of receptor-interacting serine-threonine kinase (Ripk) 3. Additionally, complementation of a T cell-specific caspase 8 deficiency with a loss of Ripk3 gives rise to lymphoproliferative disease reminiscent of lpr or gld mice. "
2.	Ischemia 10/01/2015 - "Mitochondrial Cyclophilin D as a Potential Therapeutic Target for Ischemia-Induced Facial Palsy in Rats." 09/01/2010 - "The cyclophilin D mitochondrial membrane permeability transition pore is critical in adult ischemia, whereas in neonatal hypoxic-ischemic (HI) brain injury, mitochondrial permeabilization appears to be primarily Bax-dependent. "
3.	Autoimmune Lymphoproliferative Syndrome 04/11/2011 - "Here, through a genetic analysis, we show that necroptosis in caspase 8-deficient T cells is related neither to the programmed necrosis as defined by the requirement for mitochondrial cyclophilin D nor to autophagy as defined by the requirement for autophagy-related protein 7. Rather, survival of caspase 8-defective T cells can be completely rescued by loss of receptor-interacting serine-threonine kinase (Ripk) 3. Additionally, complementation of a T cell-specific caspase 8 deficiency with a loss of Ripk3 gives rise to lymphoproliferative disease reminiscent of lpr or gld mice. "
4.	Tuberculosis (Tuberculoses) 11/01/2018 - "Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2014 - "Gemcitabine-induced pancreatic cancer cell death is associated with MST1/cyclophilin D mitochondrial complexation."

Related Drugs and Biologics

1.	Mediator Complex Subunit 1
2.	Galectin 3 (LGALS3)
3.	Carbonic Anhydrase IV
4.	Cyclophilins (Cyclophilin)
5.	Caspases
6.	Peptidylprolyl Isomerase (Prolyl Isomerase)
7.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
8.	Cadherins (E-Cadherin)
9.	Sodium Channels (Sodium Channel)
10.	Tyrosine (L-Tyrosine)

Related Therapies and Procedures

1.	Induced Hypothermia