CSK Tyrosine-Protein Kinase

Protein tyrosine kinases that phosphorylate tyrosine residues located in the C-terminal tails of SRC-FAMILY KINASES.

Also Known As:

CSK-src; p50(csk); C Terminal Src Kinase; CSK Tyrosine Protein Kinase; CSK src; CSK, Tyrosine-Protein Kinase; Carboxy Terminal Src Kinase; Kinase CSK, Tyrosine-Protein; Kinase c-src, Protein-Tyrosine; Kinase, C-Terminal Src; Kinase, CSK Tyrosine-Protein; Kinase, Carboxy-Terminal Src; Kinase, c-src; Kinase, c-src Tyrosine; Protein Tyrosine Kinase C Terminal Src Kinase; Protein Tyrosine Kinase c src; Src Kinase, C-Terminal; Src Kinase, Carboxy-Terminal; Tyrosine Kinase, c-src; Tyrosine Protein Kinase CSK; Tyrosine-Protein Kinase, CSK; c src Kinase; c src Tyrosine Kinase; c-src, Protein-Tyrosine Kinase; C-Terminal Src Kinase; Carboxy-Terminal Src Kinase; Protein Tyrosine Kinase p50(csk); Protein-Tyrosine Kinase C-Terminal Src Kinase; Protein-Tyrosine Kinase c-src; Tyrosine Protein Kinase p50csk; Tyrosine-Protein Kinase CSK; c-src Kinase; c-src Tyrosine Kinase

Networked: 204 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Oneyama, Chitose: 10 articles (02/2020 - 03/2007)
2.	Okada, Masato: 9 articles (06/2015 - 03/2007)
3.	Angelucci, Adriano: 3 articles (03/2022 - 07/2006)
4.	Botta, Maurizio: 3 articles (03/2022 - 03/2007)
5.	Schenone, Silvia: 3 articles (03/2022 - 03/2007)
6.	Sovari, Ali A: 3 articles (01/2016 - 11/2011)
7.	Okada, M: 3 articles (03/2012 - 01/2000)
8.	Sanjay, Archana: 3 articles (01/2011 - 04/2004)
9.	Nishimura, Riko: 3 articles (05/2010 - 08/2003)
10.	Yoneda, Toshiyuki: 3 articles (05/2010 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "c-Src tyrosine kinase plays roles in a wide range of signaling events and its increased activity is frequently observed in a variety of epithelial and non-epithelial cancers. " 01/01/2022 - "The tyrosine kinase c-Src is upregulated in a wide variety of human cancers and is involved in promoting sEV secretion, suggesting its role in malignant progression. " 02/01/2020 - "The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor progression remain unclear. " 01/01/2020 - "Furthermore, our findings strongly suggest that SFK inhibitors should be used in the treatment of HCC and other cancers with aberrant c-Src kinase activity to improve mitochondrial energy metabolism." 07/02/2018 - "The tyrosine kinase c-Src is frequently overexpressed and activated in a wide variety of human cancers. "
2.	Osteoporosis 03/01/2022 - "Our results showed that Semen Cuscutae exhibited anti-osteoporosis effects through the c-fos/c-Src kinase/NFATC1 signaling pathway." 09/01/2000 - "Recently, inhibitors of the tyrosine kinase c-Src, have for the first time been shown to reduce bone loss after estrogen withdrawal in an animal model of osteoporosis. " 04/01/2009 - "c-Src kinase play an important role in cell growth and differentiation and its inhibitors can be useful for the treatment of various diseases, including cancer, osteoporosis, and metastatic bone disease. "
3.	Bone Diseases (Bone Disease) 04/01/2009 - "c-Src kinase play an important role in cell growth and differentiation and its inhibitors can be useful for the treatment of various diseases, including cancer, osteoporosis, and metastatic bone disease. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. " 01/01/2019 - "Here, using multiple models of breast cancer driven by the oncogene ErbB2, we show that the tyrosine kinase c-Src links energy sufficiency with PRC2 overexpression via control of mRNA translation. " 01/01/2019 - "Thus, our findings suggested that phosphorylation of HDAC3 by c-Src kinase regulates the HDAC3 activity and the proliferation of breast cancer cells." 12/01/2012 - "Inhibition of c-Src tyrosine kinase predominantly blocked ER negative breast cancer cell growth, particularly the triple (i.e. " 09/01/2007 - "These results indicate a crucial role for c-Src kinase in the survival of ER-positive breast cancer cells only when ER function is blocked. "
5.	Bone Resorption 05/01/2010 - "A tyrosine kinase, c-Src, that plays an indispensable role in ruffled border formation and bone resorption is constitutively active in osteoclasts. " 09/22/2006 - "Osteoclast bone resorption is known to be dependent on the expression of the tyrosine kinase, c-Src. " 01/01/2006 - "Tyrosine kinase c-Src plays an essential role in ruffled border formation and bone resorption in osteoclasts; however, it is unclear how c-Src controls ruffled border formation during bone resorption. " 01/01/2006 - "Thus, c-Src kinase activity not only on the plasma membrane but also within mitochondria is essential for the regulation of osteoclastic bone resorption." 01/01/2000 - "The proto-oncogene c-src, which encodes a non-receptor-type tyrosine kinase c-Src, has been shown to be essential for osteoclastic bone resorption by the finding that the targeted disruption of the c-src gene induced osteopetrosis in mice. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Epidermal Growth Factor (EGF)
3.	Hyaluronic Acid (Hyaluronan)
4.	Phosphotransferases (Kinase)
5.	ErbB Receptors (EGF Receptor)
6.	Protein Tyrosine Phosphatases
7.	Mitogen-Activated Protein Kinases
8.	Integrins
9.	Cathepsin K
10.	Chloride Channels (Chloride Channel)

Related Therapies and Procedures

1.	Therapeutics
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Castration