WAP Four-Disulfide Core Domain Protein 2

A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.

Also Known As:

Networked: 20 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yao: 3 articles (07/2017 - 01/2013)
2.	Li, Ming: 3 articles (07/2017 - 01/2013)
3.	Wang, Suihai: 3 articles (07/2017 - 01/2013)
4.	Wu, Yingsong: 3 articles (07/2017 - 01/2013)
5.	Li, Ji-Liang: 2 articles (07/2017 - 02/2016)
6.	Liu, Tiancai: 2 articles (07/2017 - 02/2016)
7.	Huhtinen, K: 2 articles (06/2012 - 04/2009)
8.	Perheentupa, A: 2 articles (06/2012 - 04/2009)
9.	Poutanen, M: 2 articles (06/2012 - 04/2009)
10.	Suvitie, P: 2 articles (06/2012 - 04/2009)

Related Diseases

1.	Endometriosis 10/01/2010 - "To investigate the biochemical parameters of the erythrocyte response to diamide-induced oxidative stress, alone or as adjuncts to serum values of CA-125 and human epididymal secretory protein E4 (HE4), in the diagnosis and study of endometriosis. " 01/01/2016 - "The aim of the study was to assess the utility of serum human epididymal secretory protein E4 (HE4) biomarker in the differential diagnosis of endometriosis and adnexal malignancies. " 10/01/2010 - "Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis." 02/01/2020 - "Recently, as an ovarian cancer biomarker, human epididymal secretory protein E4 (HE4) has been increasingly investigated in the differentiating of endometrioma from ovary malignancy and in confirming the benign structure of the endometrioma. " 01/01/2014 - "By the comparison between most used tumor marker trend (cancer antigen 125: CA 125 and human epididymal secretory protein E4: HE4) before and after laparoscopic surgery, the aim of the present study was to assess HE4 usefulness in ovarian benign cyst and endometrioma diagnosis. "
2.	Neoplasms (Cancer) 07/05/2017 - "WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. " 02/29/2016 - "WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. " 04/01/2015 - "Human epididymis protein 4 (HE4), represented as an epididymis-specific gene and designated a WAP four-disulfide core domain protein 2 (WFDC2), is amplified in many tumors. " 01/01/2016 - "The aim of the study was to assess the utility of serum human epididymal secretory protein E4 (HE4) biomarker in the differential diagnosis of endometriosis and adnexal malignancies. " 07/01/2017 - "To investigate the clinical significance of human epididymal secretory protein E4 (HE4) in combination with cancer antigen 125 (CA125) in the diagnosis of endometrial cancer. "
3.	Cysts 04/21/2009 - "Human epididymal secretory protein E4 (HE4, also known as WAP four-disulphide core domain protein 2) is a new promising biomarker for ovarian cancer but its specificity against ovarian endometriotic cysts is only superficially known. " 01/01/2014 - "By the comparison between most used tumor marker trend (cancer antigen 125: CA 125 and human epididymal secretory protein E4: HE4) before and after laparoscopic surgery, the aim of the present study was to assess HE4 usefulness in ovarian benign cyst and endometrioma diagnosis. "
4.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2013 - "WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes." 07/05/2017 - "WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. " 07/05/2017 - "WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes." 02/29/2016 - "WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. " 01/06/2014 - "Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian cancer tumorigenesis but little is known about the role the HE4 gene or the gene product plays. "
5.	Endometrial Neoplasms (Endometrial Cancer) 02/01/2012 - "To explore the clinical value of combined detection of serum human epididymal secretory protein E4 (HE4) and CA(125) in the diagnosis of endometrial carcinoma. " 02/01/2012 - "[Clinical value of combined detection of serum human epididymal secretory protein E4 and CA(125) in the diagnosis of endometrial carcinoma]." 07/01/2017 - "To investigate the clinical significance of human epididymal secretory protein E4 (HE4) in combination with cancer antigen 125 (CA125) in the diagnosis of endometrial cancer. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Tumor Biomarkers (Tumor Markers)
3.	Antigens
4.	Diamide
5.	Proteins (Proteins, Gene)
6.	Folate Receptor 1
7.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
8.	Matrix Metalloproteinase 7 (Matrilysin)
9.	Matrix Metalloproteinases (MMPs)
10.	E-Selectin