Heme-Binding Proteins

Metalloproteins that contain a HEME ligand as the prosthetic group.

Also Known As:

Heme Binding Protein; Heme Binding Proteins; Protein, Heme-Binding; Proteins, Heme-Binding; Heme-Binding Protein

Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Smith, Ann: 3 articles (09/2019 - 01/2015)
2.	Choi, Hong Seo: 2 articles (01/2019 - 01/2018)
3.	Kim, Ji Yea: 2 articles (01/2019 - 01/2018)
4.	Kim, So Young: 2 articles (01/2019 - 01/2018)
5.	Ryu, Chun Jeih: 2 articles (01/2019 - 01/2018)
6.	Cai, Minghui: 2 articles (01/2017 - 01/2017)
7.	Song, Yingli: 2 articles (01/2017 - 01/2017)
8.	Zhang, Xiaolan: 2 articles (01/2017 - 01/2017)
9.	Zhu, Hui: 2 articles (01/2017 - 01/2017)
10.	Yin, Guo Nan: 1 article (01/2022)

Related Diseases

1.	Acute Erythroblastic Leukemia (Erythroleukemia) 02/01/2005 - "The approach was used to study heme-binding protein complexes in murine erythroleukemia cells. " 11/20/1998 - "Molecular characterization of a newly identified heme-binding protein induced during differentiation of urine erythroleukemia cells."
2.	Glioblastoma (Glioblastoma Multiforme) 12/21/2016 - "In this study, we report that BACH1, a heme-binding protein that participates in transcriptional repression or activation, was significantly upregulated in glioblastoma tissues. "
3.	Fibrosis (Cirrhosis) 01/01/2017 - "2-DE Gel based proteomic study demonstrated excessive lard consumption elevated the expression of fibrosis related alpha-1-antitrypsin precursor, and endoplasmic reticulum stress related proteins such as heat shock cognate 71 kDa, eukaryotic translation initiation factor 4A1 and protein disulfide isomerase associated 3. Moreover, unlike corn oil rich in PUFAs, lard had no effects to elevate the expression of glutathione S-transferases, but decreased the expression of iron store related proteins heme binding protein 1 and ferritin. "
4.	Neoplasms (Cancer) 07/01/2018 - "Progesterone receptor membrane associated component 1 is a multifunctional heme-binding protein that plays a role in several biological processes such as tumor progression, metabolic regulation, and viability control of nerve cells. " 01/01/2019 - "Progesterone receptor membrane component1 (PGRMC1) is a heme-binding protein involved in cancers and Alzheimer's disease. " 01/01/2018 - "Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional heme-binding protein involved in various diseases, including cancers and Alzheimer's disease. " 01/01/2023 - "Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding protein that has been implicated in a wide range of cell and tissue functions, including cytochromes P450 activity, heme homeostasis, cancer, female reproduction, and protein quality control. "
5.	Hemolysis 10/01/2005 - "Heme released from heme-binding proteins on internal hemorrhage, hemolysis, myolysis, or other cell damage is highly toxic due to oxidative and proinflammatory effects. " 01/01/2023 - "Hemopexin (HPX), a heme-binding protein with the highest affinity for heme in plasma, serves as an effective antagonist against heme toxicity resulting from severe acute or chronic hemolysis. " 01/01/2018 - " this chapter we will discuss the inflammatory properties of RBC-derived DAMPs with a particular focus on Hb derivatives, as well as therapeutic potential of the endogenous Hb and heme-binding proteins haptoglobin and hemopexin in the prevention of hemolysis/hemorrhage-associated inflammation." 01/01/2021 - "Addition of rA1M resulted in decreased hemolysis compared to addition of the heme-binding protein hemopexin and the radical-scavenging and reducing agents ascorbic acid and Trolox (vitamin E). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Iron
3.	Protein Disulfide-Isomerases
4.	Transferases
5.	Peptide Initiation Factors (Initiation Factor)
6.	Glutathione (Reduced Glutathione)
7.	Ferritins (Ferritin)
8.	Corn Oil (Oil, Corn)
9.	lard
10.	Heme (Haem)