Heterogeneous Nuclear Ribonucleoprotein D0

Member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) specifically binds RNA molecules that contain AU RICH ELEMENTS found within the 3'-UTR of many PROTO-ONCOGENES and CYTOKINES mRNAs. It functions as a transcription factor, binds to double- and single-stranded DNA sequences in a specific manner.

Also Known As:

hnRNP D0; AU rich Element RNA binding Protein 1, 37 kDa; AUF1 Protein, P37; AU-rich Element RNA-binding Protein 1, 37 kDa; AUF1 Protein; AUF1A Protein; P37 AUF1 Protein

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein D: 16
        Heterogeneous Nuclear Ribonucleoprotein D0: 4
        human HNRNPD protein
        mouse Hnrpd protein
        rat Hnrnpd protein
      - RNA Recognition Motif Proteins
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein D: 16
        Heterogeneous Nuclear Ribonucleoprotein D0: 4
        human HNRNPD protein
        mouse Hnrpd protein
        rat Hnrnpd protein
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein D: 16
        Heterogeneous Nuclear Ribonucleoprotein D0: 4
        human HNRNPD protein
        mouse Hnrpd protein
        rat Hnrnpd protein
      - RNA Recognition Motif Proteins
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein D: 16
        Heterogeneous Nuclear Ribonucleoprotein D0: 4
        human HNRNPD protein
        mouse Hnrpd protein
        rat Hnrnpd protein

Experts

1.	Cai, Jian-Ping: 1 article (11/2020)
2.	Chen, Fu-Jun: 1 article (11/2020)
3.	Deng, Zhou-Lu: 1 article (11/2020)
4.	Li, Dan-Ni: 1 article (11/2020)
5.	Li, Jin: 1 article (11/2020)
6.	Liu, Teng-Hui: 1 article (11/2020)
7.	Tian, Xin-Yuan: 1 article (11/2020)
8.	Wang, Jing-Jing: 1 article (11/2020)
9.	Zhang, He: 1 article (11/2020)
10.	Kao, Weiyuan John: 1 article (05/2008)

Related Diseases

1.	Carcinogenesis 06/01/2005 - "The differentially expressed genes between diffuse and nodular samples included some related to DNA stability and repair (TALDO1, PRDX2, DDB1, XRCC1, and POLB), RNA stability and degradation (OASL and AUF1), protein synthesis and processing (PFDN5, HSPD1, and NACA), cell growth (CDC25C and GRPR), and tumorigenesis and cell cycle (VIL2 and TPD52). "
2.	Sarcoma (Soft Tissue Sarcoma) 03/01/2002 - "The Tg line with the highest amount of Tg p37(AUF1) protein developed sarcomas. "
3.	Neoplasm Metastasis (Metastasis) 11/01/2020 - "AUF1 protein was upregulated in CRC tissues and CRC cells, and high expression of AUF1 was significantly associated with advanced AJCC stage (P = .001), lymph node metastasis (P = .007), distant metastasis (P = .038) and differentiation (P = .009) of CRC specimens. "
4.	Lymphatic Metastasis 11/01/2020 - "AUF1 protein was upregulated in CRC tissues and CRC cells, and high expression of AUF1 was significantly associated with advanced AJCC stage (P = .001), lymph node metastasis (P = .007), distant metastasis (P = .038) and differentiation (P = .009) of CRC specimens. "
5.	Inflammation (Inflammations) 05/01/2008 - "The remaining four proteins: high mobility group box 1, caspase recruitment domain 5, glycoprotein 96, and heterogeneous nuclear ribonucleoprotein D0 modulate inflammation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glycoproteins (Glycoprotein)
3.	DNA (Deoxyribonucleic Acid)