Hepatic Infarction

Formation of infarct resulting from obstruction of HEPATIC ARTERY and/or PORTAL VEIN most often after LIVER TRANSPLANTATION or hepatobiliary surgery.

Also Known As:

Hepatic Infarctions; Hepatic Infarcts; Infarct, Hepatic; Infarct, Liver; Infarction, Hepatic; Infarction, Liver; Liver Infarctions; Liver Infarcts; Hepatic Infarct; Liver Infarct; Liver Infarction

Networked: 151 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	HELLP Syndrome
2.	Fetal Death
3.	Ischemia
4.	Thrombosis (Thrombus)
5.	Necrosis

Experts

1.	Ni, Yicheng: 4 articles (01/2011 - 05/2006)
2.	Toyota, Naoyuki: 3 articles (01/2016 - 01/2009)
3.	Bormans, Guy: 3 articles (01/2011 - 11/2007)
4.	Nuyts, Johan: 3 articles (01/2011 - 05/2006)
5.	Prinsen, Kristof: 3 articles (01/2011 - 11/2007)
6.	Verbruggen, Alfons: 3 articles (01/2011 - 11/2007)
7.	Mortelmans, Luc: 3 articles (07/2010 - 05/2006)
8.	Arai, Yasuaki: 2 articles (09/2022 - 10/2011)
9.	Matsui, Osamu: 2 articles (09/2022 - 11/2004)
10.	Rhim, Hyunchul: 2 articles (03/2020 - 09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hepatic Infarction:

1.	Prednisolone (Predate)FDA LinkGeneric 01/01/2009 - "We report a case of HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a woman in the 17th week of pregnancy with SLE and APS who had been in remission on a regimen of low-dose prednisolone and aspirin. "
2.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2009 - "We report a case of HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a woman in the 17th week of pregnancy with SLE and APS who had been in remission on a regimen of low-dose prednisolone and aspirin. "
3.	EnzymesIBA 01/01/2019 - "Her liver enzymes continued to rapidly worsen postoperatively and immediate postpartum computed tomography of the abdomen and pelvis revealed massive hepatic infarction, 11 × 10 × 15 cm, of the right lobe of the liver. " 12/01/2014 - "There were no ischemic bowel complications; one patient experienced hepatic infarction with elevated liver enzymes. " 08/21/2006 - "We suggest that diabetic patient with elevated liver enzyme should be considered the possibility of hepatic infarction." 03/01/2020 - "Although liver enzyme levels rapidly declined after surgery and the finding of liver infarction was not observed, a large amount of watery stool was observed owing to portal hypertension, which was an adverse effect of PVA. " 01/01/2020 - "The diagnosis should be suspected by noting elevated liver enzymes, thrombocytopenia and typical images of hepatic infarction on abdominal CT. "
4.	Ethanol (Ethyl Alcohol)IBA 11/01/1998 - "In both cases, liver function parameters deteriorated immediately after the ethanol injection, and enhanced computed tomography images showed a wedge-shaped avascular low-density area due to hepatic infarction. " 01/01/1992 - "In two cases, immediately after ethanol injection, liver function tests deteriorated and computed tomography (CT) showed a wedge-shaped low-density area due to liver infarction. " 09/01/1984 - "Hepatic infarction with absolute ethanol." 06/01/1995 - "Eight dogs had liver infarcts created by percutaneous injections of ethanol. " 01/01/2011 - "The resulting (99m)Tc(CO)(3)-bis-DTPA-BI was characterized (LC-MS) and evaluated as a potential SPECT tracer for imaging of necrosis in Wistar rats with a reperfused partial liver infarction and Wistar rats with ethanol induced muscular necrosis. "
5.	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/01/2021 - "However, serum aspartate aminotransferase or alanine aminotransferase levels in all patients were well below those observed in hepatic infarction cases. " 01/01/2016 - "Although 2 patients presented with small liver infarcts, the aspartate aminotransferase and alanine aminotransferase levels did not exceed 1000 IU/L in any of the patients, and none experienced severe liver injury. " 05/01/2011 - "The development of hepatic infarction was significantly associated with a serum aspartate aminotransferase (AST) level of more than 700 IU/L and a serum alanine transferase (ALT) level of more than 500 IU/L (p = 0.031 for both, Fisher exact test). " 03/01/2012 - "Biloma/liver infarcts were managed conservatively but were associated with an increase in serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatases, and gamma glutamyl transpeptidase (p=0.005, p=0.005, p=0.012, and p=0.006, respectively). " 01/01/1982 - "Massive hepatic infarction developed characterized clinically by fever, coma, ascites, ileus, jaundice, and renal failure; and biochemically by markedly elevated SGOT and SGPT, alkaline phosphatase, total bilirubin levels, and decreased thromboplastin time. "
6.	Alanine Transaminase (SGPT)IBA 05/01/2021 - "However, serum aspartate aminotransferase or alanine aminotransferase levels in all patients were well below those observed in hepatic infarction cases. " 01/01/2016 - "Although 2 patients presented with small liver infarcts, the aspartate aminotransferase and alanine aminotransferase levels did not exceed 1000 IU/L in any of the patients, and none experienced severe liver injury. " 03/01/2012 - "Biloma/liver infarcts were managed conservatively but were associated with an increase in serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatases, and gamma glutamyl transpeptidase (p=0.005, p=0.005, p=0.012, and p=0.006, respectively). " 01/01/1982 - "Massive hepatic infarction developed characterized clinically by fever, coma, ascites, ileus, jaundice, and renal failure; and biochemically by markedly elevated SGOT and SGPT, alkaline phosphatase, total bilirubin levels, and decreased thromboplastin time. "
7.	Ethiodized Oil (Ethiodol)FDA Link 08/01/1988 - "(1) Liver infarction has occurred after L-TAE, because some lipiodol flows into the portal vein. " 11/01/2002 - "We have also reported a case of HCC in which multifocal hepatic infarction developed after TAI with SMANCS/Lipiodol. " 06/01/2001 - "It is speculated that both the arterial occlusion and the portal thrombosis caused the hepatic infarction, based on a long-term insufficiency of blood supply to the hepatocytes arising from toxic arteritis caused by SMANCS/Lipiodol." 06/01/2001 - "We report a patient with hepatocellular carcinoma who developed multiple hepatic infarction after transcatheter arterial infusion (TAI) with a suspension of styrene maleic acid neocarzinostatin (SMANCS) and Lipiodol (SMANCS/Lipiodol). "
8.	poly(maleic acid-styrene)neocarzinostatin (zinostatin stimalamer)IBA 06/01/2001 - "Multiple hepatic infarction after transcatheter arterial infusion with SMANCS." 11/01/1998 - "When PEIT is used for patients with HCC who have previously undergone TAI, especially with SMANCS, PEIT may induce hepatic infarction." 11/01/2002 - "We have also reported a case of HCC in which multifocal hepatic infarction developed after TAI with SMANCS/Lipiodol. " 06/01/2001 - "It is speculated that both the arterial occlusion and the portal thrombosis caused the hepatic infarction, based on a long-term insufficiency of blood supply to the hepatocytes arising from toxic arteritis caused by SMANCS/Lipiodol." 06/01/2001 - "We report a patient with hepatocellular carcinoma who developed multiple hepatic infarction after transcatheter arterial infusion (TAI) with a suspension of styrene maleic acid neocarzinostatin (SMANCS) and Lipiodol (SMANCS/Lipiodol). "
9.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 04/01/1989 - "To our knowledge, this is the first description of liver infarction associated with the lupus anticoagulant." 04/01/1989 - "Hepatic infarction in a patient with the lupus anticoagulant." 11/01/1995 - "We report a case of histologically documented hepatic infarction secondary to thrombosis in an end-stage renal disease patient on hemodialysis with systemic lupus erythematosus and a circulating lupus anticoagulant."
10.	Prednisone (Sone)FDA LinkGeneric 01/01/2011 - "Abdominal computed tomography showed spleen infarcts in 2 patients, bowel wall thickening in 1, and liver infarction in 1. Two patients underwent surgical intervention for acute abdomen; there was histologic evidence of small bowel infarcts and infarction of the spleen and liver in 1. Oral prednisone was administered to all 5 patients (median starting dose, 60 mg/d; range, 25-80 mg/d). " 03/01/1980 - "This episode of hepatic infarction was followed by persistent fever and cutaneous vasculitis, which resolved on prednisone therapy. "

Therapies and Procedures

1.	Surgical Decompression 04/01/2020 - "Following surgical decompression, liver function dramatically improved, but large areas of peripheral hepatic infarction had developed. "
2.	Palliative Care (Palliative Therapy) 03/01/2014 - "Except for one severe interventional complication (hepatic infarct), RFA presented as a technically feasible and safe therapeutic option for the palliative treatment of malignant biliary obstruction. "
3.	Therapeutics 04/01/2009 - "Rat model of reperfused partial liver infarction (RPLI) has been increasingly used in studying new diagnostics and therapeutics. " 10/01/2001 - "[Percutaneous hepatic infarction therapy (PIT)]." 09/01/2012 - "A trial of postpartum PEX therapy should be considered for treatment of the HELLP syndrome complicated with hepatic infarction, which is recalcitrant to conventional medical management, and fails to abate within 72-96 hours of delivery." 10/01/1998 - "Percutaneous hepatic infarction therapy holds promise as a new method of treating large hepatocellular carcinoma." 10/01/1998 - "Percutaneous hepatic infarction therapy for hepatocellular carcinoma."
4.	Ligation 01/01/1994 - "We report a case of liver infarction following unrecognized ligation of the right hepatic artery (HA) during laparoscopic cholecystectomy." 01/01/1994 - "Liver infarction following unrecognized right hepatic artery ligation at laparoscopic cholecystectomy." 07/01/1987 - "These studies indicate that minimal changes in Tc-NGA uptake occur after common bile duct ligation; Tc-NGA uptake is markedly sensitive to hepatic ischemia; decreased Tc-NGA uptake occurs during acute rejection; and hepatic infarcts are demonstrated promptly after preservation injury. " 02/01/2010 - "Possible causes of the hepatic infarction were inadvertent injury of the hepatic artery during lymph node dissection in five patients, right hepatic artery ligation in two patients, long-term clamp of the hepatic artery during hepatic arterial reconstruction in two patients, suturing for bleeding from the right hepatic artery in one patient, and celiac axis compression syndrome in one patient. "
5.	Transplantation 03/01/1997 - "We report on the sonographic appearances of three patients in whom hepatic infarction followed transplantation but who did not require retransplantation, allowing us to study the evolution of sonographic features. " 01/01/2008 - "Another error trap -- the "fundus-down" cholecystectomy has been associated with injuries in which the vascular component of the injury has been even more serious than the biliary one ie, "vasculo-biliary injuries" These vasulo-biliary injuries result in hepatic infarction requiring liver resection, possibly including transplantation. "