Homeobox A10 Proteins

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis of tissues. They bind to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Also Known As:

Networked: 41 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Taylor, Hugh S: 3 articles (02/2016 - 12/2010)
2.	Song, Chenlong: 2 articles (02/2021 - 01/2019)
3.	Zhou, Chongzhi: 2 articles (02/2021 - 01/2019)
4.	Zanatta, Alysson: 2 articles (01/2015 - 12/2010)
5.	Abe, Wakana: 2 articles (01/2014 - 07/2011)
6.	Kawano, Yukie: 2 articles (01/2014 - 07/2011)
7.	Narahara, Hisashi: 2 articles (01/2014 - 07/2011)
8.	Nasu, Kaei: 2 articles (01/2014 - 07/2011)
9.	Sun, Jungang: 1 article (06/2022)
10.	Xiao, Wei: 1 article (06/2022)

Related Diseases

1.	Endometriosis 08/17/2023 - "The keywords used were (HOXA10 OR "homeobox A10" OR PL OR HOX1 OR HOX1H OR HOX1.8) AND ("gene expression") AND (endometriosis). " 08/17/2023 - "The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. " 03/20/2023 - "The literature search was done using PubMed, Scopus, EBSCOhost, and Science Direct applying (HOXA10 OR "homeobox A10" OR "HOXA-10" OR HOX1) AND ("DNA methylation" OR methylation) AND (endometriosis OR endometrioma) as keywords. " 09/01/2018 - "Homeobox A10 may negatively regulate autophagy in endometriosis. " 12/01/2010 - "multiple lines of evidence suggest that the actions of the homeobox A10 (Hoxa10/HOXA10) gene could account for some aspects of endometriosis."
2.	Neoplasms (Cancer) 01/01/2022 - "Homeobox A10 (HOXA10) is highly expressed and plays an important role in a variety of tumors. " 02/09/2021 - "Homeobox A10 (HOXA10) belongs to the HOX gene family, which plays an essential role in embryonic development and tumor progression. " 07/01/2019 - "Homeobox A10 (HOXA10) belongs to the family of HOX genes, which are closely connected with embryonic development and serve important roles in various tumors. " 01/01/2019 - "Homeobox A10 (HOXA10) has been implicated in the development and progression of various human cancers. " 02/17/2021 - "Previous research has highlighted the ability of Homeobox A10 (HOXA10) to the promote proliferation, migration, and epithelial-mesenchymal transformation of various cancers, including lung adenocarcinoma (LAD), which is characterized by an aggressive disease course that exhibits rapid proliferation and migration, with studies suggesting histone deacetylase 1 (HDAC1) to be a downstream mediator of HOXA10. "
3.	Hypoxia (Hypoxemia) 01/01/2014 - "Herein, we summarize the recent studies in the following areas: (i) hyperacetylation of histones located in the promoter lesions of G-protein-coupled estrogen receptor 1, steroidogenic factor-1, and hypoxia-inducible factor-1 alpha genes and (ii) hypoacetylation of histones located in the promoter lesions of estrogen receptor alpha, homeobox A10, CCAAT/enhancer-binding protein alpha, p16(INK4a), p21(Waf1/Cip1), p27(Kip1), checkpoint kinase 2, death receptor 6, and E-cadherin genes. " 02/01/2020 - ": HB-EGF: heparin-binding epidermal growth factor-like growth factor; HOXA10: homeobox A10; NGFI-B: nerve growth factor-induced gene B; RIF: recurrent implantation failure; RPL: recurrent pregnancy loss; 6-MP: 6-mercaptopurine; IGFBP-1: insulin-like growth factor binding protein-1; LIF: leukemia inhibitory factor; IL-1β: Interleukin - 1β; CRISPR/Cas9: Clustered Regularly Interspaced Short Palindromic Repeats; AF-1: activation function-1 domain; HIF-1α: hypoxia-inducible factor 1α; CREB: cAMP response element binding."
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 05/01/2016 - "The present study aimed to investigate the reversal of MDR by silencing homeobox A10 (HOXA10) in adriamycin (ADR)-resistant human chronic myelogenous leukemia (CML) K562/ADM cells by modulating the expression of P-gp and MRP-1. "
5.	Prostatic Neoplasms (Prostate Cancer) 11/01/2014 - "The objectives of this study were to examine the expression levels of Homeobox A10 (HoxA10) in prostate cancer cells and to study the molecular mechanism of HoxA10-mediated regulation of prostate cancer cell growth and development. "

Related Drugs and Biologics

1.	Progesterone Receptors (Progesterone Receptor)
2.	Cadherins (E-Cadherin)
3.	Transcription Factors (Transcription Factor)
4.	Steroids
5.	Checkpoint Kinase 2
6.	Histone Deacetylase 1
7.	Death Domain Receptors
8.	Estrogen Receptor alpha
9.	CCAAT-Enhancer-Binding Protein-alpha
10.	Cyclin-Dependent Kinase Inhibitor p16