Formins

A family of multidomain microfilament proteins associated with ACTIN FILAMENTS. They generally have multiple Formin-Homology domains (e.g., FH2 domain) and additionally have a RhoGTPase-binding domain and a diaphanous inhibitory domain. Formins and homologs are involved in actin reorganization.

Also Known As:

Diaphanous Related Formin Homology Proteins; Diaphanous Related Formins; Formins, Diaphanous-Related; DIAPH Protein 1; DIAPH Protein 2; DIAPH Proteins; Diaphanous-Related Formin Homology Proteins; Diaphanous-Related Formins; FMN Protein 1; FMN Protein 2; FMN Proteins; Formin; Formin 1 Protein; Formin 2 Protein; Formin Homology Proteins

Networked: 225 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eisenmann, Kathryn M: 9 articles (01/2022 - 01/2005)
2.	Alberts, Arthur S: 8 articles (03/2019 - 01/2005)
3.	Carpén, Olli: 7 articles (11/2021 - 01/2013)
4.	Heuser, Vanina D: 7 articles (11/2021 - 01/2013)
5.	Gardberg, Maria: 6 articles (07/2020 - 01/2013)
6.	Pettee, Krista M: 5 articles (01/2022 - 01/2014)
7.	Goode, Bruce L: 5 articles (12/2020 - 05/2008)
8.	Zhu, Yichao: 4 articles (03/2021 - 01/2018)
9.	Grosse, Robert: 4 articles (01/2021 - 01/2008)
10.	Geyer, Matthias: 4 articles (01/2019 - 09/2008)

Related Diseases

1.	Glioma (Gliomas) 03/20/2019 - "Here, we evaluate whether clinically-relevant high-grade glioma patient-derived neuro-sphere invasion is sensitive to formin agonism. " 03/20/2019 - "Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres." 04/15/2016 - "Mechanical confinement triggers glioma linear migration dependent on formin FHOD3." 11/01/2023 - "We also explored the regulatory roles of abnormally expressed formin homology 2 domain-containing protein 1 (FHOD1) in glioma ferroptosis sensitivity. " 04/15/2016 - "We propose that glioma migration under confinement on laminin relies on formins, including FHOD3, but not Arp2/3 and that the low level of adhesion allows rapid antiparallel migration. "
2.	Neoplasms (Cancer) 01/01/2023 - "This study aims to explore the expressions, prognostic values, and immunological correlations of Formins in cancer. " 01/01/2023 - "The actin nucleating and polymerizing formin-like 2 (FMNL2) is upregulated in several cancers and has been shown to play important roles in cell migration, invasion, cell-cell adhesion and filopodia formation. " 01/01/2023 - "Among all Formins, DIAPH1 was enriched in tumor cells and associated with an inflamed tumor microenvironment (TME). " 01/01/2023 - "Formins showed different expression patterns, namely some were enriched in immune cells while some were enriched in tumor cells. " 01/01/2023 - "Formins are evolutionarily conserved genes and profoundly affect cancer progression. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "We conclude that the experimental studies on these formins have implications in the clinical behavior of basal-like breast cancer." 03/01/2014 - "Here we further study the contributions of mDia1 and its two most closely related formins, mDia2 and mDia3, to cortical microtubule capture and ErbB2-dependent breast carcinoma cell migration. " 11/17/2023 - "Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer." 01/01/2023 - "Specific Formins were dysregulated and immuno-biologically correlated in breast cancer (BRCA). " 01/01/2022 - "Systematic Characterization of Expression Patterns and Immunocorrelations of Formin-Like Genes in Breast Cancer."
4.	Carcinogenesis 11/28/2018 - "Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis." 06/01/2004 - "Formin homology proteins, implicated in organogenesis and carcinogenesis, are actin regulators with scaffold function. " 01/01/2022 - "Results: In this study, we comparatively analyzed cytoskeletal organization and biogenesis (GO:0007010) and tumorigenesis in the NPC transcriptome (GSE12452) and found that formin-like 2 (FMNL2) expression was significantly upregulated in NPC tumor tissues. " 01/01/2022 - "FMNL3 (Formin-like protein 3) is involved in the tumorigenesis of multiple cancers. " 01/01/2016 - "Included in the DRFs are the Formin-Like proteins, FMNL1, 2 & 3, each of which have been strongly implicated in driving tumorigenesis and metastasis of specific tumors. "
5.	Glioblastoma (Glioblastoma Multiforme) 07/29/2020 - "In cell studies, we investigated the changes in expression of the 15 human formins in primary glioblastoma cells and commercially available glioblastoma cell lines during differentiation from spheroids to migrating cells using transcriptomic analysis and qRT-PCR. " 10/25/2021 - "Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion." 07/29/2020 - "Formins FHOD1 and INF2 participate in glioblastoma cell migration. " 07/29/2020 - "Using immunohistochemistry, we studied the expression of two formins, FHOD1 and INF2, in tissue samples from 93 IDH-wildtype glioblastomas. " 07/29/2020 - "This finding implies that the formins could be future therapeutic targets in glioblastoma. "

Related Drugs and Biologics

1.	Formins
2.	Proteins (Proteins, Gene)
3.	MicroRNAs (MicroRNA)
4.	Actins (F Actin)
5.	JNK Mitogen-Activated Protein Kinases
6.	Membrane Proteins (Integral Membrane Proteins)
7.	Circular RNA
8.	Carrier Proteins (Binding Protein)
9.	GTP Phosphohydrolases (GTPases)
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Therapeutics
2.	Infant Equipment (Crib)
3.	Lasers (Laser)