Phospholipid Hydroperoxide Glutathione Peroxidase

A selenoenzyme that converts GLUTATHIONE plus FATTY ACID HYDROPEROXIDES to GLUTATHIONE DISULFIDE plus hydroxy fatty acids and water.

Also Known As:

Glutathione Peroxidase, Phospholipid-Hydroperoxide; PH GPeroxidase; Selenium Dependent Glutathione Peroxidase Type 4; GPX4 Phospholipid Hydroperoxide Glutathione Peroxidase; Glutathione Peroxidase 4; PH-GPeroxidase; PHGPx Enzyme; Phospholipid Hydroperoxide Glutathione Peroxidase GPX4; Phospholipid-Hydroperoxide Glutathione Peroxidase; Selenium-Dependent Glutathione Peroxidase Type-4

Networked: 356 relevant articles (11 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Conrad, Marcus: 9 articles (11/2021 - 09/2009)
2.	Lin, Chunmei: 5 articles (01/2016 - 11/2012)
3.	Nam, Sang-Yoon: 5 articles (01/2016 - 11/2012)
4.	Yon, Jung-Min: 5 articles (01/2016 - 11/2012)
5.	Kang, Rui: 4 articles (01/2022 - 01/2021)
6.	Liu, Jiao: 4 articles (01/2022 - 01/2021)
7.	Tang, Daolin: 4 articles (01/2022 - 01/2021)
8.	Maiorino, Matilde: 4 articles (01/2021 - 02/2005)
9.	Imai, Hirotaka: 4 articles (01/2020 - 07/2005)
10.	Baek, In-Jeoung: 4 articles (01/2016 - 04/2014)

Related Diseases

1.	Cognitive Dysfunction 01/01/2017 - "Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration." 10/01/2021 - "The results showed that GB improved the cognitive dysfunction of SAMP8 mice in the Morris water maze and novel object recognition test, which was associated with the attenuation of oxidative stress, inflammation and nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 (GPX4) pathway-mediated ferroptosis. " 11/01/2023 - "In this study, we first found that in addition to alleviating neuronal damage and cognitive impairments, H2S remarkably attenuated abnormal iron accumulation, decreased lipid peroxidation, and improved the expression of glutathione peroxidase 4, demonstrating the potent anti-ferroptosis action of H2S after TBI. "
2.	Inflammation (Inflammations) 10/01/2019 - "Glutathione peroxidase 4 (GPX4) is essential for cell membrane repair, inflammation suppression, and ferroptosis inhibition. " 10/01/2021 - "The results showed that GB improved the cognitive dysfunction of SAMP8 mice in the Morris water maze and novel object recognition test, which was associated with the attenuation of oxidative stress, inflammation and nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 (GPX4) pathway-mediated ferroptosis. " 01/01/2023 - "Moreover, MGZ pretreatment remarkably alleviated I/R-induced renal damages by inhibiting cell death and inflammation, upregulating the expression of glutathione peroxidase 4 (GPX4), and reducing iron-related lipid peroxidation in C57BL/6 N mice. " 07/15/2005 - "In the present paper, we report on the regulation of expression of PHGPx (phospholipid hydroperoxide glutathione peroxidase) and cGPx (cytosolic glutathione peroxidase) in rat PMNs in the inflammation site. " 11/01/2023 - "To investigate whether ferroptosis exists in sepsis induced intestinal injury, and to verify the association between ferroptosis in sepsis induced intestinal injury and intestinal inflammation and barrier function by stimulating and inhibiting the nuclear factor E2-related factor 2/glutathione peroxidase 4 (Nrf2/GPX4) pathway. "
3.	Cerebral Infarction 04/17/2023 - "After AST IV and PNS treatment, the cerebral infarction area of the rats was reduced; behavioural performance was improved; Fe2+, malondialdehyde, lipid peroxidation, interleukin-6, interleukin-1β, tumour necrosis factor-α and myeloperoxidase levels were reduced; and glutathione and glutathione peroxidase 4 levels were increased. " 01/01/2022 - "The results showed that cerebral infarct volume and neurological impairment scores were increased in cerebral ischemia-reperfusion rats, with impaired sensorimotor ability; furthermore, brain tissue glutathione (GSH) content was decreased, Fe2+, malondialdehyde (MDA) and lipide peroxide (LPO) content were increased, and the expression level of glutathione peroxidase 4 (GPX4), a key protein of ferroptosis, was also decreased. " 03/01/2022 - "We found that PGE2 release was correlated with the levels of reactive oxygen species, malondialdehyde, glutathione peroxidase 4, COX-2, and Spermidine/spermine N1-acetyltransferase 1. Ferroptosis can be induced by cerebral I/R, while inhibition of ferroptosis induced by cerebral I/R can inactivate PGE2 synthases, degrade enzyme, and parts of PGE2 receptors, and reduce cerebral infarct volume. " 07/01/2023 - "When we used adeno-associated virus and plasmid to up-regulate CDGSH iron sulfur domain 2 expression in the brain tissue and HT22 cell models separately, mouse neurological dysfunction was greatly improved; the cerebral infarct volume was reduced; the survival rate of HT22 cells was increased; HT22 cell injury was alleviated; the expression of ferroptosis-related glutathione peroxidase 4, cystine-glutamate antiporter, and glutathione was increased; the levels of malondialdehyde, iron ions, and the expression of transferrin receptor 1 were decreased; and the expression of nuclear-factor E2-related factor 2/heme oxygenase 1 was increased. "
4.	Neoplasms (Cancer) 01/01/2023 - "Both in vitro and in vivo studies showed that these pH-sensitive NPs significantly inhibited tumor growth by downregulating glutathione peroxidase 4 (GPX4). " 01/01/2022 - "In this study, metabolomic analyses revealed that treatment of cancer cells with glutathione peroxidase 4 (GPX4) inhibitors results in intracellular glycerol-3-phosphate (G3P) depletion. " 11/01/2023 - "Here, we used In-Cell Western assays combined with an unbiased drug screening to identify the compound N6F11 as a ferroptosis inducer that triggered the degradation of glutathione peroxidase 4 (GPX4), a key ferroptosis repressor, specifically in cancer cells. " 09/28/2023 - "A high glutathione peroxidase 4 expression level was found in 7 (16.67%) cancer tissues and 0 (0.00%) paracancerous tissues (P = .012). " 09/03/2023 - "More importantly, the nanozyme can consume GSH to inhibit glutathione peroxidase 4 (GPX4) activity, which limits tumor cell resistance to oxidative damage and triggers the tumor cell ferroptosis. "
5.	Iron Overload 01/01/2020 - "The pivotal events related to oxidative stress in ferroptosis include direct or indirect glutathione peroxidase 4 (GPX4) inhibition, ferrous iron overload, and lipid peroxidation. " 01/01/2020 - "In this review, we have summarized the mechanistic relationship between ferroptosis and cerebral ischemia, including through iron overload, downregulation of glutathione peroxidase 4, and upregulation of lipid peroxidation. " 04/25/2023 - "Local iron overload caused ferroptosis of DSCs by downregulating glutathione (GSH) and glutathione peroxidase 4 levels. " 02/01/2023 - "These changes included iron overload, enhanced lipid peroxidation, disorders of anti-acyl-coenzyme A synthetase long-chain family member 4 and glutathione peroxidase 4 levels, and abnormal morphological changes in mitochondria. " 01/01/2023 - "Of note, the mitigation of the characteristic features of ferroptosis, such as depleted glutathione (GSH) levels, inactivated glutathione peroxidase 4 (GPX4), elevated levels of lipid peroxidation and iron overload significantly relieve IBD. "

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Malondialdehyde (Propanedial)
3.	Iron
4.	Proteins (Proteins, Gene)
5.	Lipid Peroxides
6.	Heme Oxygenase-1
7.	Antiporters
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Glutamic Acid (Glutamate)
10.	Superoxide Dismutase

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Drug Therapy (Chemotherapy)
4.	Ligation
5.	Caloric Restriction