Sialyl Lewis X Antigen

A sialylated version of Lewis X antigen expressed on cell surfaces. It is a ligand for SELECTINS.

Also Known As:

NAG-1,4-F-1,3-GN; Neu5Ac-2-3-Gal-1-4-(Fuc-1-3)-GlcNAc; NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc-R; SLe(x); SLe(x)-OS; alpha-Neu5Ac-(2-3)-beta-D-Gal-(1-4)-(alpha-L-Fuc-(1-3))-beta-D-GlcNAc; Antigen, CD15s; Lewis X, Sialyl; Sialyl Lex; Sialyl SSEA 1; Sialyl Stage Specific Embryonic Antigen 1; 5-Acetylneuraminyl-(2-3)-Galactosyl-(1-4)-(Fucopyranosyl-(1-3))-N-Acetylglucosamine; CD15s Antigen; Sialyl Le(x); Sialyl Lewis X; Sialyl Lewis(x) Antigen; Sialyl Lewis(x) Tetrasaccharide; Sialyl SSEA-1; Sialyl Stage-Specific Embryonic Antigen-1; Sialyl-Lex; Sialylated Lewis X Antigen

Networked: 674 relevant articles (13 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Carbohydrate Tumor-Associated Antigens: 355
      - Lewis X Antigen: 164
        Sialyl Lewis X Antigen: 674
        6-sulfo sialyl Lewis X: 147
        6'-sulfated sialyl Lewis x
        6-O-sulfo de-N-acetylsialyl Lewis X
        mucin-type sialyl Lewis x epitope
        N-deacetylsialyl Lewis X ganglioside
        sialyl Lewis(x) ganglioside
        sialyl-trimeric-Lewis X
        tetravalent sialyl Lewis x saccharide
  - Differentiation Antigens: 2082
    - Myelomonocytic Differentiation Antigens: 1
      - Lewis X Antigen: 164
        Sialyl Lewis X Antigen: 674
        6-sulfo sialyl Lewis X: 147
        6'-sulfated sialyl Lewis x
        6-O-sulfo de-N-acetylsialyl Lewis X
        mucin-type sialyl Lewis x epitope
        N-deacetylsialyl Lewis X ganglioside
        sialyl Lewis(x) ganglioside
        sialyl-trimeric-Lewis X
        tetravalent sialyl Lewis x saccharide
- Antigens: 143924

Experts

1.	Kannagi, Reiji: 16 articles (01/2019 - 10/2002)
2.	Reis, Celso A: 15 articles (01/2021 - 11/2004)
3.	Ayabe, H: 13 articles (09/2002 - 04/2000)
4.	Nakagoe, T: 13 articles (09/2002 - 04/2000)
5.	Sawai, T: 13 articles (09/2002 - 04/2000)
6.	Nanashima, A: 12 articles (09/2002 - 04/2000)
7.	Tsuji, T: 12 articles (09/2002 - 04/2000)
8.	Yamaguchi, H: 12 articles (09/2002 - 04/2000)
9.	Yasutake, T: 12 articles (09/2002 - 04/2000)
10.	Peracaula, Rosa: 10 articles (01/2021 - 04/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2002 - "When these cells were injected into the tail vein of nude mice, cells expressing moderate amounts of sialyl Lewis x (MeWo-FTIII.M) produced a significantly greater number of lung tumor foci than did parental MeWo cells. " 05/23/2012 - "We then correlated sialyl Le(X) expression of 215 UICC stage III and IV patients with disease-free and cancer-related survival. " 04/01/2020 - "Immunohistochemical (IHC) studies demonstrated that both underglycosylated MUC1 (uMUC1) and sialyl Lewis x (sLex) to be positively associated with cutaneous metastatic primary tumors (p < 0.05). " 10/15/1993 - "The aim of the study was to elucidate whether sialyl Lex expression in tumors was correlated with patient survival. " 01/01/2023 - "Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation of cancer cells, and largely associates with their invasive and metastatic properties. "
2.	Neoplasm Metastasis (Metastasis) 12/01/1993 - "Sialyl Lea and sialyl Lex showed strong expressions in the liver metastases, significantly greater than in the primary lesions. " 06/01/2006 - "Since some of the factors, such as sLe(x), 14-3-3sigma, cyclinD1 and Rb, showed different levels of expression in the pair, these cultured cells might be meaningful tools for clarification of distant metastasis in canine mammary gland tumours." 11/10/2005 - "Mice inoculated in the mammary fat pad with sLe(x)-negative and -positive variants produced lung metastases. " 05/01/2003 - "We evaluated the role of sialyl Lewis X in liver metastasis in view of liver-associated immunity. " 05/01/2003 - "Role of sialyl Lewis X in liver metastasis in view of liver-associated immunity."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 11/01/1991 - "The sensitivity for pancreatic carcinoma was 81% for CA19-9, 84% for CA50, 82% for Span-1, 51% for sialyl SSEA-1 and 63% for Dupan-2. " 05/01/1991 - "Lex and sialyl Lex-i antigens have been regarded as pancreatic cancer-associated antigens, however, this study suggests that Lex and sialyl Lex-i are more useful markers for CIBD than CPH. " 06/01/2018 - "Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues." 02/01/1994 - "Therefore, we conclude that the combination assay with CA19-9 or a similar tumor marker, sialyl SSEA-1 or ST-439, and CEA would be appropriate for the screening of pancreatic cancer. " 02/01/1994 - "The accuracy of the tumor markers (CA19-9, sialyl SSEA-1, and ST-439) for pancreatic cancer, was almost equal (77% to 80%) and higher than that of CEA (69%). "
4.	Colorectal Neoplasms (Colorectal Cancer) 05/23/2012 - "The aim of this study was to establish a simple sialyl Le(X) staining score and to determine a potential correlation with the prognosis in a series of advanced colorectal carcinoma patients. " 05/23/2012 - "Our highly standardized and easy-to-use staining score is suitable for routine use and hence it could be recommended to evaluate sialyl Le(X)-expression as part of the standard histopathological analysis of colorectal carcinomas and to validate the score prospectively based on a larger population." 05/23/2012 - "Evidence exists that sialyl Le(X) expression is correlated with an unfavorable outcome in colorectal cancer. " 05/23/2012 - "A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer." 03/01/2002 - "High sialyl Le(x) expression may be useful in identifying a subset of node-negative colorectal cancer patients who are at high risk for recurrence."
5.	Colonic Neoplasms (Colon Cancer) 10/01/2002 - "This study compares the effects of fluid shear on the kinetics, adhesion efficiency, stability, and molecular requirements of polymorphonuclear leukocyte (PMN) binding to two colon adenocarcinoma cell-lines, the CD54-negative/sLe(x)-bearing LS174T cells and the CD54-expressing/sLe(x)-low HCT-8 cells. " 05/15/2012 - "These results suggest a significant link between sLe(x/a) expression and EMT in colon cancer cells and a pivotal role of c-Myc and CDX2 in regulating sLe(x/a) expression during EMT." 05/15/2012 - "To address the association between sLe(x/a) expression and EMT, we assessed whether sLe(x/a) are highly expressed on colon cancer cells undergoing EMT. " 01/01/2004 - "These results suggest that GnT-V induces sialyl Lewis x expression and leads colon cancer cells to metastasize by enhancing their ability to attach to vascular endothelium in distant organs, such as liver or lung. " 01/01/2004 - "Its synthesis in cells has been shown to involve GnT-V. We demonstrated that expression of sialyl Lewis x in colon cancer cells was induced by GnT-V expression. "

Related Drugs and Biologics

1.	Carbohydrates
2.	P-Selectin
3.	Oligosaccharides
4.	Lipopolysaccharides
5.	Antigens
6.	CA-19-9 Antigen (CA 19-9 Antigen)
7.	Ligands
8.	Polysaccharides (Glycans)
9.	Gangliosides
10.	I-antigen

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Intravenous Administration
4.	Microbubbles
5.	Radical Mastectomy