Microgels

Three-dimensional biocompatible polymers in micrometer size range. They are typically spherical particles in a size range of 1-350 micrometers when used for drug delivery and 3D cell culture applications.

Also Known As:

Networked: 213 relevant articles (19 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Wei: 4 articles (01/2022 - 01/2020)
2.	Dong, Shuli: 4 articles (04/2019 - 08/2017)
3.	Hao, Jingcheng: 4 articles (04/2019 - 08/2017)
4.	Wang, Yitong: 4 articles (04/2019 - 08/2017)
5.	Cao, Xiaodong: 3 articles (04/2022 - 01/2021)
6.	Dong, Hua: 3 articles (04/2022 - 01/2021)
7.	Feng, Qi: 3 articles (04/2022 - 01/2021)
8.	Brown, Ashley C: 3 articles (05/2021 - 01/2018)
9.	Mihalko, Emily: 3 articles (05/2021 - 01/2018)
10.	Pandit, Abhay: 3 articles (11/2020 - 10/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/02/1998 - "Both the water-soluble PVA and PVA microgels were accumulated in tumor tissue to a significantly greater extent than in normal tissue. " 07/17/2019 - "Furthermore, we demonstrate the ability of the hybrid microgels to isolate cancer cells with a purity of 65% and culture the cells post-isolation for further drug studies. " 07/17/2019 - "This study introduces an efficient tool composed of soft nano/hybrid immune microgels for magnetic isolation of targeted tumor cells. " 11/13/2018 - "Taken together, the results from this study provide the design strategy for creating tumor spheroids utilizing mechanically-tunable microgels as 3D cell culture platform." 01/01/2023 - "This technology is integrated into a bilayer microfluidic chip to localize an external magnetic field, consequently enhancing the capture efficiency (CE) of cancer cells labeled with the magnetic nano/hybrid microgels that are developed in the previous work. "
2.	Wounds and Injuries (Trauma) 12/15/2020 - "This type of release is attractive for the treatment of gastric wounds, which is improved by the presence of FA, conferring anti-oxidative and anti-secretory properties to the microgels." 08/15/2023 - "Furthermore, the promising results from a full-thickness wounds in rats have highlighted the enhanced healing potential of the microgel particles. " 08/15/2023 - "Studies using simulated wound models validated the microgels ability to efficiently regulate the wound exudate and create a moist environment. " 06/14/2023 - "Our study further demonstrates the fantastic opportunities of applying high-performance microgels to provide all-in-one sites for treating wound sterilization and healing." 11/01/2023 - "Using the same AC-free microgels as a 3D printing support bath, the location of each cell is preserved as it exits the needle, allowing identification of the mechanism driving mechanical trauma-induced cell death. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2020 - "Cell subtype-dependent formation of breast tumor spheroids and their variable responses to chemotherapeutics within microfluidics-generated 3D microgels with tunable mechanics." 10/12/2019 - "CaA@Dox microgels with pH-dependent release property significantly enhances the cell killing rate against human breast cancer cells (MCF-7). " 10/01/2023 - "With this, the excellent anti-recurrence and anti-metastasis efficacy of the microgels are demonstrated in an orthotopic breast cancer mouse model. " 01/01/2022 - "Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis." 07/01/2020 - "Herein, uniform-sized spherical microgels encapsulated with different subtypes of breast tumor cells, based on tumor aggressiveness, are developed by flow-focusing microfluidics technology. "
4.	Bacterial Infections (Bacterial Infection) 10/01/2022 - "Microgels can be effective in treatment of bacterial infections. " 05/21/2019 - "In the mouse model, the local injection of the microgels promotes tissue recovery after bacterial infections. " 05/21/2019 - "This work presents a PDA nanoparticle-functionalized microgel for topical bacterial infection treatments by removing PFTs, which could inspire future infection treatments." 05/21/2019 - "In this study, we show a polydiacetylene (PDA) nanoparticle-functionalized microgel for managing topical bacterial infections. " 05/21/2019 - "Polydiacetylene-Nanoparticle-Functionalized Microgels for Topical Bacterial Infection Treatment."
5.	Ischemia 08/10/2014 - "Furthermore, injection of the multifunctional microgel into a hindlimb ischemia model improved blood flow perfusion and increased the capillary density by histological analysis. " 11/01/2020 - "The softest microgels were tested at a low cell dose (5 × 104 cells) in a preclinical hindlimb ischemia model showing accelerated formation of new blood vessels with a reduced inflammatory response impeding progression of tissue damage. " 10/01/2014 - "Finally, optimised hMSC embedded microgels were shown to induce vascular repair and functional improvement in vivo in a mouse model of hind-limb ischemia. " 09/01/2016 - "Furthermore, TetOn-HGF/hUCB-MSCs encapsulated by arginine-glycine-aspartic acid (RGD)-alginate microgel induced to express HGF improved in vivo angiogenesis in a mouse hindlimb ischemia model. "

Related Drugs and Biologics

1.	Alginates
2.	Gels
3.	DNA (Deoxyribonucleic Acid)
4.	Hydrogels
5.	Interleukin-8 (Interleukin 8)
6.	Transglutaminases
7.	Minerals
8.	Glycerol (Glycerine)
9.	Adenosine (Adenocard)
10.	aspartic acid glycine arginine

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Therapeutics
3.	Injections
4.	Microspheres (Microsphere)
5.	Precision Medicine