Protein-Arginine Deiminase Type 1

A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.

Also Known As:

PAD Type I; PADI1 Protein; Peptidyl Arginine Deiminase Type 1; Peptidyl Arginine Deiminase Type I; Peptidylarginine Deiminase I; Peptidylarginine Deiminase Type 1; Peptidylarginine Deiminase Type I; Protein Arginine Deiminase 1; Protein Arginine Deiminase Type 1; Protein Arginine Deiminase Type I; Protein-Arginine Deiminase Type I

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Protein-Arginine Deiminases: 285
      - Protein-Arginine Deiminase Type 1: 2

Experts

1.	Coassolo, Sébastien: 1 article (01/2021)
2.	Daujat, Sylvain: 1 article (01/2021)
3.	Davidson, Guillaume: 1 article (01/2021)
4.	Davidson, Irwin: 1 article (01/2021)
5.	Gambi, Giovanni: 1 article (01/2021)
6.	Negroni, Luc: 1 article (01/2021)
7.	Romier, Christophe: 1 article (01/2021)
8.	Cassieri, C: 1 article (01/2014)
9.	De Felici, I: 1 article (01/2014)
10.	Marzano, C: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2). "
2.	Diverticulum 01/01/2014 - "PAD type I (inside the diverticulum) were found in 22 pts (28.6 %), Type II (in the margin of the diverticulum or between two PADs) in 36 pts (46.7 %) of which 12 cases between two PADs, type III (near the diverticulm) in 19 pts (24.7 %). "

Related Drugs and Biologics

1.	Pyruvate Kinase
2.	Enzymes
3.	Arginine (L-Arginine)
4.	arginine deiminase