Congenitally Corrected Transposition of the Great Arteries

A rare heart defect that occurs when the HEART VENTRICLES and attached valves, the MITRAL VALVE and the TRICUSPID VALVE are reversed so that the AORTA and the PULMONARY ARTERY are connected to the wrong ventricle. Although the heart valves and the two great arteries, the PULMONARY ARTERY and the AORTA are transposed, the blood flows to the correct place because the ventricles are also reversed and therefore corrects the transposition. It often occurs with other structural heart abnormalities.

Also Known As:

Networked: 234 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Heart Failure
2.	Bronchitis
3.	Ventricular Heart Septal Defects (Ventricular Septal Defect)
4.	Pulmonary Valve Stenosis (Pulmonary Stenosis)
5.	Left Ventricular Outflow Obstruction

Experts

1.	Gatzoulis, Michael A: 8 articles (01/2022 - 04/2007)
2.	Li, Wei: 5 articles (11/2022 - 04/2007)
3.	Diller, Gerhard-Paul: 5 articles (08/2022 - 03/2010)
4.	Barron, David J: 5 articles (01/2022 - 02/2005)
5.	Dimopoulos, Konstantinos: 5 articles (01/2021 - 03/2010)
6.	Mulder, Barbara J M: 5 articles (01/2021 - 05/2002)
7.	Hoffman, Piotr: 5 articles (01/2020 - 01/2017)
8.	Hua, Zhongdong: 5 articles (01/2020 - 02/2014)
9.	Klisiewicz, Anna: 5 articles (01/2020 - 01/2017)
10.	Kowalik, Ewa: 5 articles (01/2020 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenitally Corrected Transposition of the Great Arteries:

1.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)IBA 06/01/2010 - "We evaluate the systemic right ventricle (SRV) failure of congenitally corrected transposition of the great arteries using the scintigraphic studies in a case with 32-year-old male who improved the heart failure by the use of beta-adrenergic blockers. "
2.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 01/01/2015 - "Spontaneous resolution of plastic bronchitis in a patient post hemi-Mustard/bidirectional Glenn atrial switch procedure in the double-switch operation for congenitally corrected transposition of great arteries after course of Augmentin."
3.	PlasticsIBA 01/01/2015 - "Spontaneous resolution of plastic bronchitis in a patient post hemi-Mustard/bidirectional Glenn atrial switch procedure in the double-switch operation for congenitally corrected transposition of great arteries after course of Augmentin."
4.	Carvedilol (Coreg)FDA LinkGeneric 02/01/2003 - "Improved systemic ventricular function after carvedilol administration in a patient with congenitally corrected transposition of the great arteries."
5.	Radioisotopes (Radionuclides)IBA 04/01/2004 - "We undertook our study in order to evaluate right ventricular function and perfusion by conventional and contrast echocardiography in adults with congenitally corrected transposition who had not undergone cardiac surgery, comparing the echocardiographic findings with those obtained using equilibrium radionuclide ventriculography and gated single-photon emission computed tomography with Technetiumc-99 m sestamibi. " 04/01/2004 - "The method depending on descent of the tricuspid ring had the highest correlation with equilibrium radionuclide ventriculography in evaluation of right ventricular function in patients with congenitally corrected transposition. " 07/01/1989 - "Both conventional equilibrium radionuclide angiography and gated blood pool SPECT demonstrated the connection of the great vessels with both ventricles in a 15-year-old male patient with a congenitally corrected transposition of the great vessels. " 01/01/1987 - "Radionuclide angiography in congenitally corrected transposition of the great vessels in an adult." 09/01/1986 - "Congenitally corrected transposition in the adult: detection by radionuclide angiocardiography."
6.	pro-brain natriuretic peptide (1-76)IBA 08/15/2017 - "We aimed to assess the distribution of hsTnT concentrations in patients with congenitally corrected transposition of the great arteries (ccTGA) and to evaluate its relationship with sRV function and NT-proBNP. " 04/01/2015 - "Adults with TGA after Mustard operation (TGA-Mustard) or congenitally corrected-TGA (ccTGA) underwent echocardiography, electrocardiography, and NT-proBNP measurement. " 01/01/2017 - "Transthoracic echocardiographic studies and laboratory testing (N-terminal pro-B-type natriuretic peptide [NT-proBNP] assessment) were performed in patients with congenitally corrected transposition, who were scheduled for a routine examination, and the body mass index was calculated for each patient. " 05/01/2010 - "Serial measurement of the N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts poor outcome in a patient with congenitally corrected transposition of the great arteries (ccTGA)."
7.	Brain Natriuretic Peptide (Natrecor)FDA Link 11/01/2014 - "Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study." 01/01/2017 - "Transthoracic echocardiographic studies and laboratory testing (N-terminal pro-B-type natriuretic peptide [NT-proBNP] assessment) were performed in patients with congenitally corrected transposition, who were scheduled for a routine examination, and the body mass index was calculated for each patient. " 05/01/2010 - "Serial measurement of the N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts poor outcome in a patient with congenitally corrected transposition of the great arteries (ccTGA)."
8.	Tadalafil (Cialis)FDA Link 09/15/2017 - "The SERVE protocol is a double-blind, randomized placebo-controlled multicenter superiority trial to study the effect of PDE-5 inhibition with Tadalafil on RV volumes and function in patients with either D-transposition of the great arteries repaired with an atrial switch procedure or with congenitally corrected transposition of the great arteries. "
9.	ATSOIBA 01/01/2015 - "The study group comprised 20 patients after AtSO (22.7 ± 5.03 years) and 15 individuals with congenitally corrected transposition (ccTGA) (30.6 ± 19.4 years). "
10.	Anesthetics (Anesthetic Agents)IBA 12/01/2008 - "Anesthetic management of parturients with congenitally corrected transposition of the great arteries: three cases and a review of the literature." 01/01/2008 - "Anesthetic management of labor in a patient with congenitally corrected transposition of the great arteries." 02/01/2003 - "[Anesthetic management of a pregnant patient with congenitally corrected transposition of the great arteries for emergency cesarean delivery]." 11/01/2001 - "Anesthetic management of a pregnant patient with congenitally corrected transposition of the great arteries for labor and vaginal delivery." 06/01/2017 - "We discuss the anesthetic management of a 33-year-old patient with congenitally corrected transposition of the great arteries who required a ventricular assist device to maintain cardiac output during ablation of supraventricular tachyarrythmia. "

Therapies and Procedures

1.	Arterial Switch Operation 12/01/2017 - "In a cohort of congenitally corrected transposition of the great arteries (cc-TGA) and transposition of the great arteries after atrial switch procedure (d-TGA) the study objectives were: 1) to assess the change of quantitative systemic right ventricle (sRV) parameters over time and; 2) to examine the relationship of quantitative sRV parameters with adverse clinical outcomes. " 03/01/2017 - "The aims of this study were to determine the early and late outcomes of anatomic repair of congenitally corrected transposition of the great arteries (ccTGA) and to evaluate effectiveness of the hemi-Mustard procedure. " 01/01/2011 - "This study was undertaken to assess the risks and benefits of the double-switch operation using a hemi-Mustard atrial switch procedure and the bidirectional Glenn operation for congenitally corrected transposition of the great arteries. " 12/01/2010 - "Fourteen patients with systemic right ventricle following a Mustard or a Senning operation for the transposition of the great arteries, or congenitally corrected transposition were included in the study. " 05/01/2008 - "The aim of this study was to compare the outcome of the double-switch procedure for congenitally corrected transposition of the great arteries for patients completing morphologic left ventricle training by means of pulmonary artery banding with the outcome of patients whose morphologic left ventricle did not require training. "
2.	Radiofrequency Ablation 01/01/2000 - "Radiofrequency ablation successfully eliminated a posteroseptal accessory pathway in a left-sided tricuspid ring with Ebsteinlike anomaly in a patient with a congenitally corrected transposition of the great arteries." 11/01/2000 - "Radiofrequency ablation of a posteroseptal atrioventricular accessory pathway in a left-sided tricuspid ring with Ebsteinlike anomaly in a patient with congenitally corrected transposition of the great arteries." 01/01/2000 - "Radiofrequency ablation of a posteroseptal atrioventricular accessory pathway in a left-sided tricuspid ring with Ebsteinlike anomaly in a patient with congenitally corrected transposition of the great arteries."
3.	Fontan Procedure (Fontan Operation) 03/01/2021 - "We report transvenous endocardial lead implantation by an unconventional method in a patient with congenitally corrected transposition of great arteries after a bidirectional Glenn shunt." 05/13/2020 - "We describe the successful conversion from single ventricular pacing to CRT, in a case of congenitally corrected transposition of the great artery indicated for the Fontan procedure. " 01/01/2020 - "Bidirectional Glenn shunt placement as an optional palliative procedure for complex congenitally corrected transposition has favorable outcomes. " 01/01/2020 - "We report our experience with bidirectional Glenn shunt placement as a palliative procedure for complex congenitally corrected transposition. " 10/01/2018 - "Four patients had single-ventricle physiology and had undergone Fontan palliation (3 atriopulmonary and 1 intracardiac total cavopulmonary connection), 4 underwent repair of AV septal defects, 1 had congenitally corrected transposition of the great arteries (TGA), and 1 had TGA with a Mustard baffle. "
4.	Heart-Assist Devices 01/01/2023 - "Pitfalls and Possibilities of Ventricular Assist Device Support in Congenitally Corrected Transposition of the Great Arteries in Children." 03/26/2022 - "We report the first use of Heartmate 3 (HM3) in a Congenitally corrected Transposition of the Great Arteries (ccTGA) as a Systemic Ventricular Assist Device (SVAD) to treat HF. " 03/01/2016 - "We present the case of a 60-year-old man with congenitally corrected transposition of the great arteries who underwent successful placement of a Jarvik 2000 axial-flow ventricular assist device in a systemic morphologic right ventricle. " 03/01/2016 - "Jarvik 2000 axial-flow ventricular assist device placement to a systemic morphologic right ventricle in congenitally corrected transposition of the great arteries." 12/01/2015 - "Left Ventricular Assist Device Implantation in a Patient With Congenitally Corrected Transposition of the Great Arteries."
5.	Cardiac Resynchronization Therapy 08/01/2023 - "Cardiac resynchronization therapy using conduction system pacing after double-switch surgery for congenitally corrected transposition of the great arteries: a case report." 09/01/2020 - "The impact of pulmonary artery banding and cardiac resynchronization therapy for the adult patient with congenitally corrected transposition of the great arteries." 08/01/2019 - "Successful staged tricuspid valve replacement following cardiac resynchronization therapy in a congenitally corrected transposition of the great arteries." 12/01/2018 - "Implantation techniques and outcomes after cardiac resynchronization therapy for congenitally corrected transposition of the great arteries." 09/01/2017 - "Successful pregnancies after transvenous cardiac resynchronization therapy in a woman with congenitally corrected transposition of the great arteries."