Copper Transport Proteins

Membrane proteins that facilitate the transport of copper cations across biological membranes.

Also Known As:

Protein, Copper Transport; Transport Protein, Copper; Transport Proteins, Copper; Transporter, Copper; Transporters, Copper; Copper Transport Protein; Copper Transporter; Copper Transporters

Networked: 197 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Copper Transport Proteins: 197
        Copper-Transporting ATPases: 142
        Arabidopsis AtCOX17 protein
        Arabidopsis ATX1 copper chaperone
        Arabidopsis HCC1 protein
        Archaea CopB protein
        Candida albicans CRD1 protein
        Drosophila Ctr1A protein
        Drosophila Ctr1C protein
        E coli CusF protein
        E coli RcnB protein
        Enterococcus hirae CopB ATPase
        human ATOX1 protein
        human COX11 protein
        human COX17 protein
        human CUTC protein
        mouse Atox1 protein
        mouse Cox11 protein
        mouse Cox17 protein
        mouse Slc46a3 protein
        rat Atox1 protein
        rat Cox17 protein
        S cerevisiae CCC2 protein
        S cerevisiae COX17 protein
        S cerevisiae FET4 protein
        SLC31 Proteins
        zebrafish atox1 protein
        zebrafish cox17 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Copper Transport Proteins: 197
        Copper-Transporting ATPases: 142
        Arabidopsis AtCOX17 protein
        Arabidopsis ATX1 copper chaperone
        Arabidopsis HCC1 protein
        Archaea CopB protein
        Candida albicans CRD1 protein
        Drosophila Ctr1A protein
        Drosophila Ctr1C protein
        E coli CusF protein
        E coli RcnB protein
        Enterococcus hirae CopB ATPase
        human ATOX1 protein
        human COX11 protein
        human COX17 protein
        human CUTC protein
        mouse Atox1 protein
        mouse Cox11 protein
        mouse Cox17 protein
        mouse Slc46a3 protein
        rat Atox1 protein
        rat Cox17 protein
        S cerevisiae CCC2 protein
        S cerevisiae COX17 protein
        S cerevisiae FET4 protein
        SLC31 Proteins
        zebrafish atox1 protein
        zebrafish cox17 protein

Experts

1.	Lutsenko, Svetlana: 7 articles (01/2022 - 09/2009)
2.	Fukai, Tohru: 7 articles (11/2019 - 11/2008)
3.	Ushio-Fukai, Masuko: 7 articles (11/2019 - 11/2008)
4.	Sudhahar, Varadarajan: 6 articles (11/2019 - 08/2012)
5.	Litwin, Tomasz: 5 articles (05/2022 - 10/2018)
6.	Kaler, Stephen G: 5 articles (01/2020 - 10/2010)
7.	Howell, Stephen B: 5 articles (01/2011 - 12/2003)
8.	Safaei, Roohangiz: 5 articles (01/2011 - 12/2003)
9.	Hamilton, James P: 4 articles (01/2022 - 01/2016)
10.	Muchenditsi, Abigael: 4 articles (11/2021 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2023 - "The effect of copper transporters on chemosensitivity has been demonstrated in a variety of malignancies. " 01/01/2023 - "Thus,cuproptosis-related genes and copper transporters will be the focus of cancer research in future. " 01/01/2023 - "The implications and prospect of cuproptosis-related genes and copper transporters in cancer progression." 05/01/2013 - "This review summarises our current understanding of these two copper transporters and highlights their roles in cellular processes, embryonic development, differentiation, cancer, immunity and disease." 06/08/2021 - "While many mechanisms have been proposed for Pt-drug transport, the high-affinity copper transporter (hCtr1), Cu chaperone (Atox1), and Cu exporters (ATP7A and ATP7B) are also involved in cDDP transport, highlighting Cu homeostasis regulation in Pt-based cancer therapy. "
2.	Menkes Kinky Hair Syndrome (Menkes Disease) 11/17/2023 - "The gene mutated in Menkes disease, ATP7a , encodes a copper transporter that is known to act in the trans-Golgi sub-cellular compartment. " 02/01/2012 - "The copper transporter ATP7A has attracted significant attention since the discovery of its gene mutation leading to human Menkes disease. " 01/01/2012 - "Its essentiality is demonstrated by Menkes disease, an X-linked copper deficiency disorder characterized by defects in nervous-, cardiovascular- and skeletal systems, and is caused by mutations in the ATP7A copper transporter. " 01/01/2012 - "Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis." 09/01/2007 - "Mutations in the copper-transporter ATP7A lead to severe neurodegeneration in the mottled brindled hemizygous male (MoBr/y) mouse and human patients with Menkes disease. "
3.	Ototoxicity 01/01/2020 - "The results obtained in the current study suggest that the modulation of copper transporters locally may represent a new strategy against platinum drugs ototoxicity." 01/01/2020 - "The expression of copper transporters associated with the ototoxicity induced by platinum-based chemotherapeutic agents." 07/14/2010 - "Role of the copper transporter, CTR1, in platinum-induced ototoxicity." 07/14/2010 - "The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid tumors. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/01/2014 - "Overexpression of copper transporter CTR1 in the brain barrier of North Ronaldsay sheep: implications for the study of neurodegenerative disease." 09/21/2018 - "Menkes disease is a lethal neurodegenerative disorder of copper metabolism caused by mutations in an evolutionarily conserved copper transporter, ATP7A. " 03/01/2007 - "Menkes disease is a rare neurodegenerative disorder due to an intracellular defect of a copper transport protein. " 01/01/2005 - "Menkes disease (MD) is a neurodegenerative disorder caused by mutation of the copper transporter ATP7A. " 07/16/2004 - "Menkes' disease is a neurodegenerative disorder, recessive X chromosome linked (Xp13.3) that normally codify an ATPasa copper transporter. "
5.	Meningoencephalitis 01/01/2012 - "Previous studies correlated expression levels of a Ctr4 copper transporter to development of meningoencephalitis in a patient cohort of solid-organ transplants, but a direct role for Ctr4 in mammalian pathogenesis has not been demonstrated. " 11/24/2014 - "However, during the onset of meningoencephalitis, expression of the copper transporters is induced and is critical for Cryptococcus virulence. " 09/01/2015 - "We also characterized genes uniquely absent in each lineage, including a copper transporter absent from VGIV, which influences Cryptococcus survival during pulmonary infection and the onset of meningoencephalitis. " 11/24/2014 - "Here we demonstrate that two Cryptococcus copper transporters, Ctr1 and Ctr4, differentially influence fungal survival during pulmonary infection and the onset of meningoencephalitis. "

Related Drugs and Biologics

1.	Platinum
2.	Copper
3.	Cisplatin (Platino)
4.	Proteins (Proteins, Gene)
5.	Adenosine Triphosphatases (ATPase)
6.	Polymers
7.	Cations
8.	Iron
9.	P-type ATPases
10.	Metals

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Therapeutics
4.	Chelation Therapy (Therapy, Chelation)
5.	Immunotherapy