Rumination Syndrome (Rumination Disorder)

A gastrointestinal disorder characterized by repetitive and effortless regurgitation of ingested food from the stomach to the oral cavity in the early POSTPRANDIAL PERIOD. It is associated with functional gastrointestinal pathology (e.g., increased intra-gastric pressure) and psychiatric disorders (e.g., anxiety, depression). It is not limited to infants and distinct from GERD and VOMITING.

Also Known As:

Networked: 37 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
2.	Eructation (Eructations)
3.	Vomiting
4.	Gastroesophageal Reflux (GERD)
5.	Propionic Acidemia

Experts

1.	McCallum, Richard W: 3 articles (01/2020 - 08/2014)
2.	Bredenoord, Albert J: 2 articles (10/2020 - 07/2014)
3.	Halland, Magnus: 2 articles (01/2019 - 10/2018)
4.	Cooper, Chad J: 2 articles (12/2014 - 08/2014)
5.	Galvis, Juan M: 2 articles (12/2014 - 08/2014)
6.	Mojtahedzadeh, Mona: 2 articles (12/2014 - 08/2014)
7.	Otoukesh, Salman: 2 articles (12/2014 - 08/2014)
8.	Kessing, Boudewijn F: 2 articles (07/2014 - 11/2011)
9.	Chumpitazi, Bruno P: 1 article (12/2021)
10.	Febo-Rodriguez, Liz: 1 article (12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rumination Syndrome:

1.	BaclofenFDA LinkGeneric 01/01/2019 - "A recent randomized trial of baclofen at a dose of 10 mg three times daily led to symptomatic improvement in 63% of patients with rumination syndrome. " 05/01/2023 - "Nearly half of our patients with rumination syndrome improved after baclofen. " 05/01/2023 - "We identified 44 children with rumination syndrome who were prescribed baclofen by a pediatric gastroenterologist. " 05/01/2023 - "We performed a retrospective review of children aged 0-18 years with rumination syndrome based on Rome criteria and prescribed baclofen by a pediatric gastroenterologist at the Nationwide Children's Hospital, Columbus, Ohio, USA, between 2012 and 2019. " 05/01/2023 - "Outcomes of baclofen treatment in children with rumination syndrome have not been described. "
2.	AntralIBA 10/01/2021 - "Antral mast cell (peak 18.5±6.5 vs. 12.5±2.7) and eosinophil (peak 9.6±5.2 vs. 4.9±2.1) densities were significantly greater in patients with rumination syndrome as compared to controls. "
3.	Proton Pump InhibitorsIBA 01/01/2021 - "Behavioral disorders, such as supragastric belching (SGB) and rumination syndrome (RS), which may be treated by cognitive behavioral therapy, are common in patients with reflux symptoms refractory to proton pump inhibitors (PPI). " 01/01/2020 - "In adults, 20% of patients presenting with Proton Pump Inhibitors refractory Gastro-Esophageal Reflux Disease (GERD) have rumination syndrome. "
4.	AcidsIBA 01/01/1991 - "Decrease in lower esophageal sphincter (LES) pressure and frequent acid reflux were observed in 3 of 5 adult patients with rumination syndrome confirmed by antroduodenal manometry. " 02/01/2018 - "Exposure to intrinsic gastrointestinal acids is associated with anorexia nervosa, bulimia nervosa, rumination syndrome, or gastroesophageal reflux. "
5.	Urea (Carbamide)FDA LinkGeneric 01/01/2020 - "AEs occurred in 7 of the 24 subjects (29.2%) and included upper respiratory tract infection, dizziness, merycism, intervertebral disc protrusion, influenza-like disease, hematuria, prostatitis, and elevated blood urea nitrogen. "
6.	NitrogenIBA 01/01/2020 - "AEs occurred in 7 of the 24 subjects (29.2%) and included upper respiratory tract infection, dizziness, merycism, intervertebral disc protrusion, influenza-like disease, hematuria, prostatitis, and elevated blood urea nitrogen. "
7.	EmeticsIBA 09/01/1995 - "Using our comprehensive population-based data resource (the Rochester Epidemiology Project), we identified cases by screening 777 medical records with diagnoses of bulimia; feeding disturbance; rumination syndrome; adverse effects of cathartics, emetics, or diuretics; polyphagia; sialosis; or vomiting. "
8.	DiureticsIBA 09/01/1995 - "Using our comprehensive population-based data resource (the Rochester Epidemiology Project), we identified cases by screening 777 medical records with diagnoses of bulimia; feeding disturbance; rumination syndrome; adverse effects of cathartics, emetics, or diuretics; polyphagia; sialosis; or vomiting. "
9.	Cathartics (Purgatives)IBA 09/01/1995 - "Using our comprehensive population-based data resource (the Rochester Epidemiology Project), we identified cases by screening 777 medical records with diagnoses of bulimia; feeding disturbance; rumination syndrome; adverse effects of cathartics, emetics, or diuretics; polyphagia; sialosis; or vomiting. "
10.	CannabinoidsIBA 10/01/2011 - "The present article also mentions certain features of special interest in the diagnosis and treatment of rumination syndrome, thoracic pain of possible esophageal origin and cannabinoid-induced hyperemesis syndrome."

Therapies and Procedures

1.	Therapeutics 01/01/2019 - "This review discusses recent studies which examined the pathophysiology, diagnoses and therapy of rumination syndrome. " 01/01/2020 - "Patients who fulfilled the Rome IV criteria for rumination syndrome received hands-on instructions and/or coaching on diaphragmatic breathing techniques, were given relaxing auditory media, started on a TCA, and completed a follow-up symptoms questionnaire after undergoing a minimum of 3 months of this therapy. " 10/01/2018 - "The main therapy for rumination syndrome is behavioral modification with postprandial diaphragmatic breathing. " 04/01/2017 - "The purpose of this review was to critically appraise recent key developments in the pathophysiology, diagnosis and therapy for rumination syndrome. " 04/01/2017 - "The mainstay of the treatment of rumination syndrome is behavioral therapy via diaphragmatic breathing in addition to patient education and reassurance. "
2.	Psychology Biofeedback (Biofeedback) 12/25/2017 - "Further studies on the long term effects of biofeedback therapy as well as a proper strategy for refractory rumination syndrome are needed." 01/01/2019 - "Behavioral therapy consisting of diaphragmatic breathing, with or without biofeedback, remains the most effective treatment strategy for patients with rumination syndrome." 10/01/2018 - "Best Practice Advice 4: Diaphragmatic breathing with or without biofeedback is the first-line therapy in all cases of rumination syndrome. " 04/01/2017 - "A literature search using OVID (Wolters Kluwer Health, New York, NY, USA) to examine the MEDLINE database its inception until May 2016 was performed using the search terms "rumination syndrome," "biofeedback therapy," and "regurgitation." References lists and personal libraries of the authors were used to identify supplemental information. " 12/01/2023 - "Functional gastrointestinal disorders such as rumination syndrome and supragastric belching may be effectively treated using biofeedback. "
3.	Sign Language 01/01/1989 - "Based on six cases of severe merycism, the author studies the sign-language and the diagnostic in order to specify the positive elements that must have brought about the illness. "
4.	Gastrectomy 12/01/2014 - "Corrigendum: Cooper et al, Subtotal Gastrectomy as "Last Resort" Consideration in the Management of Refractory Rumination Syndrome." 08/01/2014 - "Subtotal Gastrectomy as "Last Resort" Consideration in the Management of Refractory Rumination Syndrome." 12/01/2021 - "IFA has been described as a pathophysiologic factor in several gastrointestinal disorders including functional dyspepsia, diabetic gastropathy, post-Nissen fundoplication, postsurgical gastrectomy, and rumination syndrome. "
5.	Catheters 11/01/2011 - "We aimed to improve the diagnosis of rumination syndrome by classification of separate rumination symptoms using (1) an ambulatory manometry/impedance (AMIM) measurement and (2) a single-catheter high-resolution manometry/impedance (HRIM) measurement. " 10/01/2020 - "This article aimed to review the clinical implications of ambulatory esophageal manometry for various symptoms, covering literature on the manometry catheter, interpretation of findings, and relevance in clinical practice specific to the evaluation of non-cardiac chest pain, chronic cough, and rumination syndrome."