Lumefantrine

A fluorene derivative that is used in combination with ARTEMETHER for the treatment of MALARIA (see ARTEMETHER-LUMEFANTRINE DRUG COMBINATION).

Also Known As:

Benflumetol; Benflumetol, (+)-isomer; Benflumetol, (+-)-isomer; Benflumetol, (-)-isomer; 9H-Fluorene-4-methanol, 2,7-dichloro-9-((4-chlorophenyl)methylene)-alpha-((dibutylamino)methyl)-, (Z)-

Networked: 196 relevant articles (24 outcomes, 30 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	White, Nicholas J: 9 articles (01/2021 - 06/2006)
2.	Tarning, Joel: 9 articles (01/2020 - 09/2009)
3.	Parikh, Sunil: 7 articles (01/2020 - 08/2009)
4.	Aweeka, Francesca T: 6 articles (12/2020 - 08/2009)
5.	Mårtensson, Andreas: 6 articles (07/2020 - 04/2010)
6.	Nosten, François: 6 articles (10/2015 - 06/2006)
7.	Davis, Timothy M E: 5 articles (01/2022 - 03/2010)
8.	Ogutu, Bernhards: 5 articles (01/2021 - 04/2010)
9.	Huang, Liusheng: 5 articles (12/2020 - 12/2015)
10.	Aklillu, Eleni: 5 articles (02/2020 - 04/2015)

Related Diseases

1.	Malaria 08/01/1999 - "The lumefantrine component is absorbed variably in malaria, and is eliminated more slowly (half-life of 3 to 6 days). " 02/11/2020 - "Geometric mean (± SD) day 7 lumefantrine plasma concentration between cured and recurrent malaria was not statistically different in both treatment arms [158.5 (± 2.4) vs 100.0 (± 1.5) ng/ml, (p = 0.28) for generic arm and 158.5 (± 2.3) vs 251.2 (± 4.2) ng/ml, (p = 0.24) for innovator arm]. " 02/11/2020 - "Further studies are recommended to establish the day 7 plasma lumefantrine concentration cut-off point to predict malaria treatment outcome in children." 01/01/2020 - "A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41% HIV-malaria-coinfected, 36% malaria-infected, 20% HIV-infected, and 3% healthy volunteers). " 01/01/2016 - "Day 7 plasma concentrations of lumefantrine (LF) can serve as a marker to predict malaria treatment outcome in different study populations. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 03/01/2012 - "This study was conducted to correlate blood concentrations of lumefantrine with treatment outcome for patients with Plasmodium falciparum malaria when the drug was given without specific instructions for administration with food. " 09/01/2009 - "The objective of this study was to determine the population pharmacokinetic properties of lumefantrine in pregnant women with uncomplicated multidrug-resistant Plasmodium falciparum malaria on the northwestern border of Thailand. " 01/01/2022 - "The lumefantrine terminal elimination half-life (median 9.5 days) was longer than reported in healthy volunteers and adults with falciparum malaria. " 05/01/2017 - "Oil-Fortified Maize Porridge Increases Absorption of Lumefantrine in Children with Uncomplicated Falciparum Malaria." 10/01/2015 - "Lumefantrine and Desbutyl-Lumefantrine Population Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria on the Thailand-Myanmar Border."
3.	Infections 10/01/2022 - "Lumefantrine plasma concentrations below 175ng/ml and 200ng/ml on day 3 and 7 did not affect adequate clinical and parasitological response (ACPR) and recurrence of infection (p = 0.428 and 0.239 respectively). " 11/01/2021 - "Chemoprophylaxis under sporozoites-lumefantrine (CPS-LMF) immunization induce protective immune responses against Plasmodium yoelii sporozoites infection in mice." 09/01/2013 - "HIV-positive nigerian adults harbor significantly higher serum lumefantrine levels than HIV-negative individuals seven days after treatment for Plasmodium falciparum infection." 01/01/2022 - "knowlesi infections received six doses of artemether (1.7 mg/kg) plus lumefantrine (10 mg/kg) over 3 days. " 12/16/2020 - "We obtained parasite survival rates of 41 isolates for dihydroartemisinin (DHA) and lumefantrine (LUM) out of 51 infections tested by ring-stage survival assay (RSA) against DHA. "
4.	Lung Neoplasms (Lung Cancer) 11/01/2019 - "The present work aim to develop pH responsive nanosystem comprising lumefantrine with calcium phosphate nanoparticles loaded lipidic cubosomes for the effective treatment of lung cancer. " 11/01/2019 - "pH responsive delivery of lumefantrine with calcium phosphate nanoparticles loaded lipidic cubosomes for the site specific treatment of lung cancer." 03/01/2021 - "Conventional treatment options for lung cancer treatment were restricted due to non-specific nature and side effects, with this associated problem and to overcome this we had developed lumefantrine with nano calcium phosphate loaded lipid nanoparticles (LF- CaP- Ls) affording pH sensitive mechanism. " 03/01/2021 - "In vivo synergistic anti-tumor effect of lumefantrine combined with pH responsive behavior of nano calcium phosphate based lipid nanoparticles on lung cancer." 03/01/2021 - "Further, reduced lung cancer progression of lumefantrine with nano calcium phosphate loaded lipid nanoparticles (LF-CaP-Ls) treated mice were assessed by measuring the 5-methyltetrahydrofolate (MTHF) in serum. "
5.	Vector Borne Diseases 07/22/2014 - "Based on these results, in January 2013 the expert committee of the National Vector Borne Disease Control Programme formulated the first subnational drug policy for India and selected artemether plus lumefantrine as the new first-line treatment in the northeast. "

Related Drugs and Biologics

1.	Artemether
2.	Lumefantrine Drug Combination Artemether (Coartem)
3.	Chloroquine (Aralen)
4.	artemisinin (artemisinine)
5.	Artesunate
6.	Antimalarials (Antimalarial Agents)
7.	Mefloquine (Lariam)
8.	Amodiaquine (Camoquin)
9.	artenimol (dihydroartemisinin)
10.	piperaquine

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Aftercare (After-Treatment)
4.	Oral Administration
5.	Injections