Pancreatic Intraductal Neoplasms

EPITHELIAL NEOPLASMS with pancreatic ductal differentiation that arise from the EXOCRINE PANCREAS and grow mostly within the PANCREATIC DUCTS. They are characterized by the presence of intraductal masses with mostly papillary growth pattern. Overt production of MUCIN within the pancreatic duct is associated with pancreatic intraductal papillary-mucinous neoplasm but not intraductal tubulopapillary neoplasm.

Also Known As:

Intraductal Papillary Mucinous Neoplasms of the Pancreas; Intraductal Papillary-Mucinous Neoplasm, Pancreatic; Intraductal Tubulopapillary Neoplasm, Pancreatic; Pancreatic IPMN; Pancreatic Intraductal Papillary Mucinous Neoplasm; Pancreatic Intraductal Tubulopapillary Neoplasm; IPMN, Pancreatic; Intraductal Neoplasm, Pancreatic; Intraductal Neoplasms, Pancreatic; Intraductal Papillary Mucinous Neoplasm, Pancreatic; Neoplasm, Pancreatic Intraductal; Pancreatic IPMNs; Pancreatic Intraductal Neoplasm

Networked: 91 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms, Cystic, Mucinous, and Serous
2.	Carcinoma (Carcinomatosis)
3.	Pancreatic Neoplasms (Pancreatic Cancer)
4.	Neoplasms (Cancer)
5.	Adenocarcinoma

Experts

1.	Furukawa, Toru: 5 articles (03/2021 - 12/2011)
2.	Morikawa, Takanori: 5 articles (03/2021 - 12/2011)
3.	Motoi, Fuyuhiko: 5 articles (03/2021 - 12/2011)
4.	Unno, Michiaki: 5 articles (03/2021 - 12/2011)
5.	Maker, Ajay V: 4 articles (03/2018 - 01/2011)
6.	Yamamoto, Masakazu: 3 articles (03/2021 - 12/2011)
7.	Kanno, Atsushi: 3 articles (09/2020 - 11/2006)
8.	Lillemoe, Keith D: 3 articles (06/2020 - 12/2016)
9.	Mino-Kenudson, Mari: 3 articles (06/2020 - 12/2016)
10.	Allen, Peter J: 3 articles (01/2018 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pancreatic Intraductal Neoplasms:

1.	AntigensIBA 02/01/2014 - "The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion." 09/26/2022 - "Carbohydrate antigen 125 supplements carbohydrate antigen 19-9 for the prediction of invasive intraductal papillary mucinous neoplasms of the pancreas." 02/01/2014 - "BG type and tumor BG-antigen (glycoprotein) expression (studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. " 01/01/2015 - "Serum carcinoembryonic antigen and carbohydrate antigen 19-9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta-analysis."
2.	Pregnenolone Carbonitrile (PCN)IBA 11/01/2008 - "The aims of this study were to evaluate the prevalence and associated factors of EPMs in IPMN patients and to compare these data with those of non-IPMN pancreatic cystic neoplasm (PCN) patients. "
3.	Epithelial Cell Adhesion MoleculeIBA 04/01/2013 - "In this study, we examined immunohistochemical expression of EpCAM in the pancreatic IPMNs in order to clarify its clinicopathological significance. "
4.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "However, They have not investigated the significance of these proteins for development of pancreatic intraductal papillary mucinous neoplasm (IPMN). " 02/01/2015 - "Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas." 02/01/2006 - "Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis." 01/01/2006 - "Intraductal papillary mucinous neoplasms of the pancreas: an analysis of protein expression and clinical features." 03/01/2004 - "Correlation between patterns of DNA mismatch repair hmlh1 and hmsh2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas."
5.	MucinsIBA 01/01/2012 - "A recent consensus conference classified pancreatic IPMN (P-IPMN) into 4 subtypes (ie, gastric, intestinal, pancreatobiliary, oncocytic) based on morphologic appearance and mucin (MUC) staining properties. " 03/10/2013 - "Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are potentially malignant intraductal epithelial neoplasms which consist of columnar, mucin-containing cells and arise from the epithelium of the main pancreatic duct or its branches. " 09/01/2012 - "Intraductal papillary mucinous neoplasms of the pancreas are defined as mucin-producing neoplasms arising in the main pancreatic duct (main duct type), its major branches (branch duct type), or in both (mixed type). " 06/01/2012 - " Intraductal papillary neoplasm of the bile duct (IPNB), a novel entity of biliary disease, is recently advocated as the counterpart of pancreatic intraductal papillary mucinous neoplasm (IPMN) because both are in common with a large amount of mucin production and papillary growth. " 01/01/2011 - "Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas."
6.	Biomarkers (Surrogate Marker)IBA 03/01/2018 - "A comprehensive analysis of molecular diagnostics and biomarkers in intraductal papillary mucinous neoplasms of the pancreas." 01/01/2017 - "Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas." 02/01/2015 - "Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms." 09/01/2020 - "To clarify the usefulness of cancer-related inflammation, hypermetabolism, and subsequent host malnutrition biomarkers for predicting the histological grades of intraductal papillary mucinous neoplasms of the pancreas (IPMNs). " 09/01/2015 - "Plasma MicroRNAs as Novel Biomarkers for Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas."
7.	Carcinoembryonic AntigenIBA 08/01/2019 - "Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation." 03/01/2012 - "The carcinoembryonic antigen level in pancreatic juice and mural nodule size are predictors of malignancy for branch duct type intraductal papillary mucinous neoplasms of the pancreas." 01/01/2015 - "Serum carcinoembryonic antigen and carbohydrate antigen 19-9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta-analysis."
8.	MicroRNAs (MicroRNA)IBA 01/01/2015 - "A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas." 09/01/2015 - "Plasma MicroRNAs as Novel Biomarkers for Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas."
9.	Telomerase (Telomerase Reverse Transcriptase)IBA 01/01/2008 - "Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas." 04/01/2008 - "This pathologically unique tumor is the first case of mixed ductal-endocrine carcinoma derived from pancreatic IPMN and telomerase activation could play a potential role in the neoplastic progression of mixed ductal-endocrine carcinomas of the pancreas."
10.	Polysaccharides (Glycans)IBA 07/01/2015 - "Serum N-glycan profiles in patients with intraductal papillary mucinous neoplasms of the pancreas." 04/01/2023 - "The malignant potential of pancreatic intraductal papillary mucinous neoplasm is reflected in expression levels of fucosylated glycans in α1 -acid glycoprotein."

Therapies and Procedures

1.	Therapeutics 06/01/2020 - "There is limited data on the efficacy of adjuvant therapy (AT) in patients with invasive intraductal papillary mucinous neoplasms of the pancreas (IPMN). " 10/01/2023 - "Impact of adjuvant therapy in patients with invasive intraductal papillary mucinous neoplasms of the pancreas: an international multicenter cohort study." 06/01/2020 - "Impact of adjuvant therapy in patients with invasive intraductal papillary mucinous neoplasms of the pancreas." 02/01/2012 - "[Surgical therapy of intraductal papillary mucinous neoplasms of the pancreas]." 11/01/2008 - "[Intraductal papillary mucinous neoplasms of the pancreas: pro surgical therapy--pro surveillance]."
2.	Pancreatectomy 01/01/2020 - "Pancreatic intraductal tubulopapillary neoplasm progression requiring completion pancreatectomy: A case report and literature review." 08/01/2014 - "Parenchyma-sparing pancreatectomy for presumed noninvasive intraductal papillary mucinous neoplasms of the pancreas." 06/01/2014 - "Middle-preserving pancreatectomy for multifocal intraductal papillary mucinous neoplasms of the pancreas: report of a case." 01/14/2010 - "A 60-year-old Caucasian male underwent a total pancreatectomy for a mixed type pancreatic intraductal papillary mucinous neoplasm (IPMN) arising in the main and secondary pancreatic ducts. " 10/01/2007 - "Outcomes after pancreatectomy for intraductal papillary mucinous neoplasms of the pancreas: an institutional experience."
3.	Pancreaticoduodenectomy 01/01/2023 - "Intraoperative pancreatoscopy in pancreaticoduodenectomy for intraductal papillary mucinous neoplasms of the pancreas: Application to the laparoscopic approach." 12/01/2015 - "A pancreatoduodenectomy was performed to identify this pancreatic intraductal neoplasm. " 11/01/2023 - "A retrospective search for patients with pancreatic IPMNs who underwent partial pancreatectomy at an academic center from 2006 to 2014 identified 63 patients, including 42 who had pancreaticoduodenectomy (PD) and 21 who had distal pancreatectomy (DP). " 09/01/2021 - "of pancreatoduodenectomy or distal pancreatectomy, versus total pancreatectomy (TP), for pancreatic IPMNs. " 11/01/2016 - "Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report."
4.	Gastroscopes 01/01/2015 - "Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm."
5.	Endoscopes 07/01/2011 - "In conclusion, direct peroral cholangioscopy and pancreatoscopy using the ultra-slim endoscope is an efficient tool for diagnosis of PB fistula and pancreatic IPMN."