Lumefantrine Drug Combination Artemether (Coartem)

Drug combination of artemether and lumefantrine that is used to treat PLASMODIUM FALCIPARUM MALARIA.

Also Known As:

Coartem; Artemether, Lumefantrine Drug Combination; Artemether - Benflumetol; Artemether Benflumetol; Artemether Lumefantrine; Artemether, Benflumetol Drug Combination; Artemether-Benflumetol Combination; Artemether-Lumefantrine Combination; CGP 56697; CGP-56697; Co-Artemether; Artemether Benflumetol Combination; Artemether Lumefantrine Combination; Benflumetol, Artemether; CGP56697; Co Artemether; Lumefantrine, Artemether

Networked: 873 relevant articles (223 outcomes, 219 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Dorsey, Grant: 35 articles (12/2021 - 05/2006)
2.	Kamya, Moses R: 30 articles (02/2022 - 05/2006)
3.	Rosenthal, Philip J: 28 articles (01/2021 - 05/2006)
4.	White, Nicholas J: 26 articles (01/2022 - 10/2004)
5.	Ringwald, Pascal: 21 articles (05/2022 - 12/2006)
6.	Mårtensson, Andreas: 21 articles (07/2020 - 10/2005)
7.	Sagara, Issaka: 20 articles (08/2021 - 10/2006)
8.	Staedke, Sarah G: 19 articles (12/2021 - 05/2006)
9.	D'Alessandro, Umberto: 19 articles (10/2021 - 08/2006)
10.	Björkman, Anders: 17 articles (06/2020 - 10/2005)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 05/24/2019 - "Artemether-lumefantrine (AL) is the most commonly used ACT for treatment of falciparum malaria in Africa but there is limited evidence on the safety and efficacy of AL in HIV-infected individuals on ART, among whom drug-drug interactions are expected. " 10/13/2016 - "Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria from three highly malarious states in India." 02/11/2013 - "One patient showed an increase in gametocytes from four on Day 0 to 68, per 500 WBC on Day 2. Artemether lumefantrine is highly efficacious against uncomplicated Plasmodium falciparum malaria. " 06/01/2003 - "We concluded that both DNP and Coartem/ Riamet were safe, well tolerated and highly efficacious in the treatment of acute uncomplicated falciparum malaria in Thailand." 06/01/1999 - "These six-dose regimens of artemether-lumefantrine provide a highly effective and very well-tolerated treatment for multidrug-resistant falciparum malaria."
2.	Malaria 02/28/2011 - "In 2002, the first-line treatment for uncomplicated malaria was changed to artemether-lumefantrine (AL) that has proved to be highly efficacious against multidrug resistant Plasmodium falciparum. " 05/26/2023 - "Artemether-lumefantrine agents, the recommended first-line treatment for uncomplicated malaria with APIs outside the recommended pharmacopeial content assay limit is common especially in high malaria transmission settings. " 01/01/2021 - "In Kenya, artemether-lumefantrine (AL) is the recommended first-line treatment of uncomplicated malaria. " 06/01/2009 - "Shortly after Kenya introduced artemether-lumefantrine (AL) for first-line treatment of uncomplicated malaria, we conducted a pre-post cluster randomized controlled trial to assess the effect of providing malaria rapid diagnostic tests (RDTs) on recommended treatment (patients with malaria prescribed AL) and overtreatment (patients without malaria prescribed AL) in outpatients >/= 5 years old. " 06/11/2008 - "Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. "
3.	Infections 06/01/1998 - "Generally, CGP 56697 showed a superior clearance rate, successfully cleared higher parasite densities and suppressed new infections over a longer period of time. " 06/15/2013 - "Multicenter and randomized trials, however, are needed for a better understanding of the efficacy of artemether-lumefantrine against schistosome infection with ranges of intensity." 10/19/2012 - "Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana." 01/01/2020 - "Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated Plasmodium falciparum infection in Colombia. " 12/01/2022 - "falciparum infection using rapid diagnostic tests (RDTs), and treated students who tested positive with artemether-lumefantrine. "
4.	Parasitemia 08/01/2007 - "Artemether-lumefantrine clears parasitemia more rapidly than ASP but both combinations are effective in treatment of uncomplicated P. " 11/22/2021 - "Parasitemia rapidly cleared with artemether/lumefantrine. " 10/12/2022 - "Artemether-lumefantrine was initiated at a GM of 12.1 days (95% CI 11.5-12.7), and a GM parasitemia of 6,101 parasites/mL (1,587-23,450). " 01/01/2022 - "falciparum Parasitemia following Treatment of Artemether-Lumefantrine in Ethio-Sudan Border, Western Ethiopia." 01/01/2021 - "However, patients who received artemether-lumefantrine and were qPCR positive at 72 h were significantly more likely to have microscopically detectable recurrent Plasmodium falciparum parasitemia by day 42 than those receiving other regimens and experienced, on average, a shorter interval before the next clinical episode. "
5.	Reinfection 06/03/2021 - "Reinfection and recrudescence were then grouped as recurrent infections and analyzed together by PCR-restriction fragment length polymorphism (RFLP) to identify candidate markers for artemether-lumefantrine tolerance in the P. " 06/24/2019 - "The artemether-lumefantrine PCR-corrected adequate clinical and parasitological response rate was 100%, with only one re-infection found among the 128 patients who completed 42-day follow-up. " 02/27/2012 - "The efficacy of artemether-lumefantrine for treatment of uncomplicated malaria is still high in the study area although the rate of re-infection is higher than previously reported. " 07/01/2006 - "After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). " 05/15/2018 - "The day-28 adequate clinical and parasitological response in the per-protocol population, PCR-corrected for reinfections, was 98.9% (93/94, 95% CI 94.2-99.8) for pyronaridine-artesunate and 96.4% (81/84, 95% CI 90.0-98.8) for artemether-lumefantrine. "

Related Drugs and Biologics

1.	Artesunate
2.	Amodiaquine (Camoquin)
3.	artemisinin (artemisinine)
4.	piperaquine
5.	artenimol (dihydroartemisinin)
6.	pyrimethamine drug combination fanasil (Fansidar)
7.	Lumefantrine Drug Combination Artemether (Coartem)
8.	Mefloquine (Lariam)
9.	Antimalarials (Antimalarial Agents)
10.	Lumefantrine

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Insecticide-Treated Bednets
4.	Chemoprevention
5.	Art Therapy