Icodextrin (Extraneal)

A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.

Also Known As:

Networked: 234 relevant articles (15 outcomes, 34 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Johnson, David W: 7 articles (01/2022 - 02/2003)
2.	Kawanishi, Hideki: 5 articles (01/2022 - 01/2005)
3.	Sloand, James A: 5 articles (01/2020 - 10/2012)
4.	Wang, I-Kuan: 5 articles (12/2019 - 03/2015)
5.	Yen, Tzung-Hai: 5 articles (12/2019 - 03/2015)
6.	Boudville, Neil: 4 articles (01/2022 - 09/2016)
7.	Davenport, Andrew: 4 articles (01/2020 - 09/2003)
8.	Sud, Kamal: 4 articles (01/2020 - 09/2016)
9.	Lin, Cheng-Li: 4 articles (12/2019 - 01/2018)
10.	Topley, Nicholas: 4 articles (10/2018 - 01/2012)

Related Diseases

1.	Peritonitis 02/01/2004 - "Icodextrin-induced peritonitis: study of five cases and comparison with bacterial peritonitis." 07/01/1995 - "Twenty-three control (C) and 22 icodextrin (I) patients experienced peritonitis during the study. " 01/01/2021 - "The Fisher's exact test and unpaired t-test showed that the difference in the prevalence of PD-related peritonitis (P = 0.009), peritonitis/patient years (P = 0.036), the BMI (P = 0.007) and icodextrin (P = 0.001) were significant. " 09/10/2016 - "In contrast, a low proportion of automated PD exposure, high icodextrin exposure and low or high use of antifungal prophylaxis at the time of peritonitis were associated with a higher peritonitis rate. " 09/01/2015 - "All patients were treated with neutral PDS excluding icodextrin, during their entire PD treatment, and experienced no episode of peritonitis. "
2.	Inflammation (Inflammations) 01/01/2017 - "Discontinuation of icodextrin as a possible factor provoking systemic inflammation had no impact on the course of the disease. " 06/01/2008 - "Icodextrin PDF-induced intraperitoneal inflammation was investigated based on changes in peritoneal permeability and inflammatory reactions. " 06/01/2008 - "Icodextrin and intraperitoneal inflammation." 01/01/2001 - "We evaluated the effect of icodextrin on peritoneal permeability and inflammation in an experimental chronic peritoneal dialysis (PD) model with repeated dwell studies (DSs) in non uremic rats. " 01/01/2016 - " words: biocompatibility - icodextrin - inflammation - peritoneal dialysis - peritoneal dialysis solutions."
3.	Insulin Resistance 11/01/2015 - "Reducing insulin resistance in patients undergoing peritoneal dialysis through the use of icodextrin-based solutions." 11/01/2015 - "The substitution of glucose for icodextrin for the long dwell improved insulin resistance measured by HOMA index in non-diabetic APD patients." 11/01/2015 - "The aim of our study was to analyse the effect of the substitution of glucose for icodextrin on insulin resistance in non-diabetic PD patients in a multicentric randomized clinical trial. " 06/01/2008 - "However, the effects of icodextrin on insulin resistance and adipocytokine profile remain unclear. " 01/01/2007 - "The purpose of this study was to examine the insulin resistance in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) with standard glucose and icodextrin containing solutions. "
4.	Chronic Kidney Failure (Chronic Renal Failure) 12/01/2019 - "From the Taiwan National Health Insurance database, we identified 4040 icodextrin users and 3517 non-users among 7557 patients newly diagnosed with end-stage renal disease undergoing PD from 2005 to 2011. " 01/01/2008 - "Our results show that icodextrin produces significantly higher UF in long-day dwell in diabetic ESRD patients on CCPD than in non-diabetic patients. " 01/01/2005 - "These preliminary observations suggest that a single nocturnal exchange with icodextrin can be an effective treatment in patients affected by refractory CHF and moderate-to-severe chronic renal failure." 01/01/1997 - "To review all clinical studies and experience gained with icodextrin to date; primarily its use in peritoneal dialysis in patients with end-stage renal failure, but also its use as an intraperitoneal vehicle. " 03/01/2018 - "A solitary icodextrin exchange may therefore be reasonable initial therapy for some incident ESRD patients."
5.	Neoplasms (Cancer) 04/01/2003 - "In subsequent studies we compared prolongation of survival in intraperitoneal PC-3 and MDAH-2774 human xenograft tumor models in nude mice using rAd-p53 in icodextrin or PBS in multi-dose ranging (1 x 10(8) to 1 x 10(10) P) experiments. " 04/01/2003 - "In PC-3 tumor-bearing mice treated IP with 5 x 10(9) P/0.5 ml or 1 x 10(10) P/0.5 ml rAd-betagal, transgene expression was significantly enhanced (p < 0.01) with icodextrin compared to PBS in both tumor specimens and peritoneal wall. " 12/01/2020 - "(ii) Icodextrin significantly inhibited cancer nodule formation in the scar and the incision or peritoneal damaged zones after surgery. " 12/01/2006 - "There was no adverse affect of icodextrin on vector replication in the ovarian cancer cell lines nor murine model tumor samples evaluated. " 03/01/2005 - "However, peroperative intra-abdominal treatment with icodextrin did not affect intraperitoneal tumor cell adhesion and growth of free intra-abdominal tumor cells in rats with this model of severe peritoneal trauma. "

Related Drugs and Biologics

1.	Solutions
2.	Glucose (Dextrose)
3.	Glucans
4.	Dialysis Solutions
5.	Anti-Bacterial Agents (Antibiotics)
6.	Phosphates (Orthophosphate)
7.	Guanosine Diphosphate (GDP)
8.	Creatinine
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Ringer's Lactate

Related Therapies and Procedures

1.	Peritoneal Dialysis
2.	Renal Dialysis (Hemodialysis)
3.	Glycemic Control
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Therapeutics