Ibandronic Acid (Boniva)

Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS.

Also Known As:

Boniva; (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate; 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate; BM 21.0955; BM 210955; BM-21.0955; BM-210955; Bondronat; Bonviva; Ibandronate; Ibandronate Sodium; Ibandronate Sodium Anhydrous; Ibandronic Acid, Sodium Salt, Monohydrate; RPR 102289A; RPR-102289A; BM21.0955; BM210955; RPR102289A; Phosphonic acid, (1-hydroxy-3-(methylpentylamino)propylidene)bis-

Networked: 659 relevant articles (106 outcomes, 238 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - Diphosphonates: 11565
      - Ibandronic Acid: 659

Experts

1.	Bauss, Frieder: 18 articles (12/2015 - 01/2003)
2.	Hashimoto, Junko: 13 articles (03/2019 - 01/2007)
3.	Reginster, Jean-Yves: 13 articles (06/2014 - 08/2005)
4.	Body, Jean-Jacques: 13 articles (01/2008 - 09/2004)
5.	Body, J J: 10 articles (11/2011 - 06/2000)
6.	Felsenberg, Dieter: 9 articles (04/2015 - 08/2004)
7.	Miller, Paul D: 9 articles (10/2013 - 03/2005)
8.	Bauss, F: 9 articles (12/2011 - 01/2000)
9.	Delmas, Pierre D: 9 articles (04/2009 - 05/2002)
10.	Christiansen, C: 9 articles (05/2006 - 10/2001)

Related Diseases

1.	Osteoporosis 09/01/2009 - "After the Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE) study had demonstrated the strong vertebral and nonvertebral antifracture efficacy of daily and intermittent oral ibandronate, the Monthly Oral Ibandronate In Ladies (MOBILE) study gave evidence for an increased efficacy on the bone mineral density (BMD) of higher intermittent oral ibandronate doses (150 mg monthly) compared with 2.5 mg daily. " 03/01/2018 - "These findings confirm the favorable safety and consistent effectiveness of ibandronate, and indicate that monthly IV ibandronate would be beneficial in daily practice for the treatment of Japanese patients with osteoporosis." 04/01/2008 - "A significantly greater proportion of participants who selected intravenous versus oral treatment had a primary diagnosis of osteoporosis (72.2% vs 57.1%, respectively; P<0.001) and a history of fracture as an adult (35.6% vs 22.4%; P >or= 0.004); significantly fewer recipients of intravenous versus oral ibandronate were currently working (29.0% vs 39.5%; P >or= 0.021). " 04/11/2022 - "This study sought to compare the efficacy of monthly oral ibandronate for retaining bone mineral density (BMD) in diabetic and non-diabetic postmenopausal women with osteoporosis. " 08/01/2003 - "Efficacy of 2-mg ibandronate injected every 3 months was tested in men with osteoporosis over 2 yr, in a prospective, open study. "
2.	Pain (Aches) 06/01/2014 - "Excellent pain reduction (pain at rest and under strain) and improved mobility was reported within the first two weeks after the first ibandronate administration by sixteen patients (64%). " 01/01/2010 - "The EQ-5D questionnaire showed significant improvement associated with ibandronate treatment, occurring in mobility (p < 0.01), usual activity (p < 0.01), pain/discomfort (p < 0.05), and anxiety/depression (p < 0.05). " 11/01/2004 - "Ibandronate has also been shown to provide significant and sustained relief from metastatic bone pain over 2 years of treatment, improving patient functioning and quality of life. " 12/01/2012 - "In this pilot study, we investigated the therapeutic efficacy of intravenous Ibandronate compared to pain medication on the outcome of bone marrow edemas (BME) of the knee and talus. " 01/01/2012 - "Quality of life scores also showed a greater improvement in group A, both at 6 and 12 months after surgery, likely because of the pain-reducing effects of ibandronate treatment."
3.	Postmenopausal Osteoporosis 04/01/2008 - "This meticulous methodology provided a highly effective means of identifying vertebral fractures and recruiting the trial population in which to assess the efficacy of ibandronate in postmenopausal osteoporosis." 01/01/2005 - "These simple ibandronate regimens are expected to provide the optimal combination of efficacy, tolerability and patient convenience, leading to improved treatment adherence and thus, enhanced outcomes in postmenopausal osteoporosis." 08/01/2008 - "In conclusion, 150-mg monthly oral ibandronate is an effective and well-tolerated long-term treatment for postmenopausal osteoporosis, with consistent improvement in BMD and bone turnover during 3 years' continuous treatment." 04/01/2006 - "Once-monthly ibandronate is an effective and well-tolerated treatment option for postmenopausal osteoporosis." 04/01/2006 - "Once-monthly ibandronate is an effective and well-tolerated treatment for patients with postmenopausal osteoporosis. "
4.	Breast Neoplasms (Breast Cancer) 11/01/2009 - "Efficacy of ibandronate for the treatment of skeletal events in patients with metastatic breast cancer." 10/01/2013 - "German adjuvant intergroup node-positive study: a phase III trial to compare oral ibandronate versus observation in patients with high-risk early breast cancer." 01/01/2006 - "Long-term safety of intravenous ibandronic acid for up to 4 years in metastatic breast cancer: an open-label trial." 01/01/2006 - "Our in vitro study examined the cytotoxic effects resulting from combinations of ibandronate and ionising radiations (RX) in various sequences on breast cancer cells. " 01/01/2005 - "In a 2-year, phase III study of patients with breast cancer metastatic to bone, the incidence of adverse renal events in patients treated with 6 mg i.v. ibandronate was low and comparable with that of placebo (4% versus 4.5% with placebo). "
5.	Bone Diseases (Bone Disease) 12/01/2004 - "With its favorable efficacy and safety profile, and the added convenience of the oral formulation, ibandronate provides improved treatment options for managing metastatic bone disease." 11/01/2007 - "These results indicate that ibandronate may be an effective treatment for patients with metastatic bone disease following CRC. " 05/01/2004 - "Oral ibandronate is an effective and well-tolerated treatment for metastatic bone disease. " 01/01/2005 - "Efficacy of ibandronate in metastatic bone disease: review of clinical data." 12/01/2008 - "This trial is the first to compare directly the clinical response to and safety of oral and intravenous (IV) ibandronic acid for metastatic bone disease. "

Related Drugs and Biologics

1.	Diphosphonates (Bisphosphonates)
2.	Alendronate (Alendronate Sodium)
3.	Zoledronic Acid (Zometa)
4.	Ibandronic Acid (Boniva)
5.	Risedronic Acid (Actonel)
6.	Nitrogen
7.	Pamidronate (Aredia)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Clodronic Acid (Clodronate)
10.	Glucocorticoids

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Intravenous Administration
4.	Aftercare (After-Treatment)
5.	Oral Administration