Edaravone

An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.

Also Known As:

1-Phenyl-3-methyl-5-pyrazolone; 3-Methyl-1-phenyl-2-pyrazolin-5-one; Edarabone; MCI 186; MCI-186; Norantipyrine; Norphenazone; Phenylmethylpyrazolone; Radicava; 1 Phenyl 3 methyl 5 pyrazolone; 3 Methyl 1 phenyl 2 pyrazolin 5 one; MCI186; 3H-pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

Networked: 924 relevant articles (207 outcomes, 262 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Pyrazolones: 41
        Antipyrine: 530
        Edaravone: 924

Experts

1.	Abe, Koji: 26 articles (05/2021 - 11/2003)
2.	Yamashita, Toru: 13 articles (05/2021 - 04/2009)
3.	Yamamoto, Yorihiro: 9 articles (05/2022 - 01/2009)
4.	Kikuchi, Kiyoshi: 9 articles (01/2017 - 06/2009)
5.	Agnese, Wendy: 8 articles (01/2022 - 01/2018)
6.	Apple, Stephen: 8 articles (01/2022 - 01/2019)
7.	Mitsuno, Masataka: 8 articles (12/2017 - 01/2007)
8.	Miyamoto, Yuji: 8 articles (12/2017 - 01/2007)
9.	Tanaka, Hiroe: 8 articles (12/2017 - 01/2007)
10.	Yamamura, Mitsuhiro: 8 articles (12/2017 - 01/2007)

Related Diseases

1.	Ischemic Stroke 01/01/2023 - "As a proof of concept, intrinsic strain-mediated ultrathin ceria nanoplates could boost antioxidation for improved ischemic stroke treatment in vivo, significantly better than edaravone, a commonly used clinical drug." 01/01/2022 - "Edaravone is a promising treatment for ischemic stroke patients, with a more favorable time window. " 01/01/2019 - "Conclusions- For any ischemic stroke subtype, edaravone use (compared with no use) was associated with a greater improvement in neurological symptoms, although the difference was small (<1 point NIHSS) and of limited clinical significance." 12/01/2021 - "In conclusion, the results of the present study demonstrated that NBP and edaravone effectively prevented ischemic stroke damage with multi‑target protective effects. " 12/01/2021 - "The aim of the present study was to explore whether the co‑administration of NBP and edaravone had multi‑target protective effects on the neurovascular unit (NVU) of mice affected by ischemic stroke. "
2.	Ischemia 01/06/2012 - "Edaravone also significantly reduced the locomotor activity deficit 72h after ischemia and improved memory impairment. " 08/20/2008 - "Previous reports have confirmed that edaravone has protective effects against ischemia-reperfusion (IR) injury of many organs. " 06/01/2019 - "In this experimental study, we aimed to investigate the efficacy of edaravone on renal injury due to acute lower limb ischemia/reperfusion in a rat model. " 02/01/2017 - "The purpose of the experiment was to study the efficacy of edaravone in enhancing flap viability after ischemia/reperfusion (IR) and its mechanism. " 06/01/2019 - "In the ischemia/ reperfusion group, the histopathological changes were improved by edaravone. "
3.	Cerebral Infarction 02/01/2012 - "Treatment with edaravone (3 and 10 mg/kg) significantly diminished the cerebral infarct, oedema volume and improved functional recovery of neurological deficits. " 01/01/2013 - "These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction." 10/01/2007 - "The mechanism by which MCI-186 (3-methyl-1-phenyl-2-prazolin-5-one) exerts protective effects during cerebral infarction, other than its function as a radical scavenger, has not been fully elucidated. " 10/01/2019 - "The state of the rats in three edaravone groups was improved compared with that of the cerebral infarction group. " 10/01/2005 - "Edaravone is a newly developed radical scavenging agent that has been used for protection against I/R injury in patients with cerebral infarction. "
4.	Infarction (Infarctions) 05/01/2020 - "Edaravone significantly improved hemodynamics after AMI (p < 0.05) and reduced the total infarct volumes (p < 0.05). " 10/01/2007 - "Edaravone significantly improved the neurological outcome (p<0.05) and reduced the total infarct volumes (p<0.05), compared with saline control. " 06/01/2005 - "In addition, edaravone-treatment provided a significant reduction in the number of TUNEL-positive apoptotic cells, a decrease in Bax immunoreactivity and an increase in Bcl-2 expression within the peri-infarct area. " 06/01/2014 - "We report 2 cases with acute brainstem and brainstem-cerebellar infarction showed improvement of their signs and symptoms after administration of edaravone. " 11/01/2006 - "Edaravone improved cardiac function and left ventricular remodelling 14 days after infarction. "
5.	Stroke (Strokes) 02/26/2021 - "We hypothesized that edaravone is beneficial in improving neurological impairment resulting from acute stroke. " 01/01/2014 - "Edaravone is a promising treatment for stroke. " 02/26/2021 - "This is the first randomized controlled trial to assess the efficacy of edaravone for treating acute stroke. " 02/26/2021 - "Safety and efficacy of edaravone for patients with acute stroke: A protocol for randomized clinical trial." 01/01/2023 - "The goal of this study is to evaluate and analyze the effects of edaravone (EDV) dexborneol on neurological function and serum inflammatory factor levels among patients with acute anterior circulation big artery blockage stroke. "

Related Drugs and Biologics

1.	Free Radical Scavengers
2.	Antioxidants
3.	Free Radicals
4.	Hydroxyl Radical
5.	Neuroprotective Agents
6.	ozagrel
7.	argatroban (MPQA)
8.	Oxygen (Dioxygen)
9.	Riluzole
10.	3-n-butylphthalide (butylphthalide)

Related Therapies and Procedures

1.	Therapeutics
2.	Activities of Daily Living (ADL)
3.	Warm Ischemia
4.	Transplantation
5.	Ligation