Caspofungin (Cancidas)

A cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic MYCOSES.

Also Known As:

Cancidas; Caspofungin Acetate; Caspofungin MSD; L 743,872; L 743872; L-743,872; L-743872; MK 0991; MK-0991; L743,872; L743872; MK0991; Tetradecanamide, N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-((2-aminoethyl)amino)-20-((1R)-3-amino-1-hydroxypropyl)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)tetracosahydro-2,11,15-trihyd roxy-6-((1R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxo-1H-dipyrrolo(2,1-c:2',1'-l)(1,4,7,10,13,16)hexaazacycloheneicosin-9-yl)-10,12-dimethyl-

Networked: 1096 relevant articles (166 outcomes, 182 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kontoyiannis, Dimitrios P: 20 articles (03/2021 - 07/2003)
2.	Cornely, Oliver A: 17 articles (09/2019 - 09/2004)
3.	Lewis, Russell E: 16 articles (03/2021 - 07/2003)
4.	Kartsonis, Nicholas A: 16 articles (06/2015 - 09/2002)
5.	Walsh, Thomas J: 14 articles (09/2020 - 01/2002)
6.	Najvar, Laura K: 11 articles (11/2019 - 07/2003)
7.	Sable, Carole A: 11 articles (09/2007 - 02/2002)
8.	Pappas, Peter G: 10 articles (12/2021 - 10/2003)
9.	Patterson, Thomas F: 10 articles (11/2019 - 08/2002)
10.	Wiederhold, Nathan P: 10 articles (11/2019 - 08/2003)

Related Diseases

1.	Aspergillosis 01/01/2022 - "The efficacy of caspofungin in the treatment of cerebral aspergillosis documented here, if confirmed in other animal models (especially immunosuppressed murine models) and by using additional Aspergillus isolates across a range of CAS minimal effective concentrations (MECs), would suggest that caspofungin merits further study as a treatment option for patients suffering from aspergillosis disseminated to the brain." 01/01/2022 - "Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis." 01/01/2022 - "In this study, we assessed cerebral drug exposure and efficacy of caspofungin (CAS) using a lethal infant rat model of cerebral aspergillosis. " 12/01/2011 - "In first-line treatment of invasive aspergillosis, daily doses of up to 200 mg caspofungin were well tolerated and the maximum tolerated dose was not reached. " 01/15/2006 - "Efficacy of caspofungin against invasive Candida or invasive Aspergillus infections in neutropenic patients."
2.	Infections 01/01/2011 - "The recently introduced caspofungin (CPF) offers an excellent safety profile, but underperformed in terms of efficacy against mold infections. " 04/01/2008 - "The therapeutic efficacy of caspofungin in relation to the severity of invasive pulmonary infection caused by Aspergillus fumigatus in transiently neutropenic rats was investigated by using rat survival and the decrease in the fungal burden as the parameters of efficacy. " 11/03/2016 - "Our study identifies a bacterial target for caspofungin and indicates that IcaA inhibitors could potentially be useful in the treatment of biofilm-related infections." 01/01/2020 - "Combination of this compound with caspofungin eradicated drug-resistant C. albicans infection while sparing co-cultured human cells. " 09/01/2013 - "In a murine model of disseminated infection, we evaluated the efficacy of caspofungin at 5 mg/kg against 8 strains of C. "
3.	Invasive Candidiasis 07/01/2011 - "These data suggest that caspofungin dose escalation for invasive candidiasis may not be consistently effective against resistant C. " 08/01/2007 - "Caspofungin has demonstrated efficacy in invasive candidiasis. " 08/01/2010 - "A multicentre study to evaluate the impact of timing of caspofungin administration on outcomes of invasive candidiasis in non-immunocompromised adult patients." 05/01/2010 - "We identified 212 patients with invasive candidiasis due to non-albicans Candida species (>or=5 cases per species) in 5 clinical trials of caspofungin monotherapy from the pharmaceutical sponsor's (Merck and Co., Inc.) database: 71 cases were caused by C. " 06/15/2009 - "A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis."
4.	Candidiasis (Moniliasis) 01/01/2001 - "Caspofungin was effective in patients with oropharyngeal or oesophageal candidiasis, according to the preliminary results of 2 randomised double-blind trials. " 01/01/2020 - "Investigate the efficacy of caspofungin in participants <3 months of age with invasive Candida infection (ICI). " 07/01/2011 - "Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis." 04/01/2011 - "Efficacy of a single 6 mg/kg versus two 3 mg/kg caspofungin doses for treatment of disseminated candidiasis caused by Candida albicans in a neutropenic mouse model." 01/01/2019 - "Single caspofungin doses used in mice in this study are attainable in humans as well, suggesting a potential place of this dosing strategy not only in prevention but also in curative treatment of evolved invasive Candida infections."
5.	Mycoses (Diseases, Fungus) 03/01/2002 - "In conclusion, the pharmacokinetics of caspofungin supports the clinical evaluation of once-daily dosing regimens for efficacy against fungal infections." 11/05/2019 - "The findings suggest that caspofungin may be considered for prophylaxis against invasive fungal disease, although study interpretation is limited by early termination due to an unplanned interim analysis that appeared to have suggested futility. " 02/01/2013 - "Caspofungin for the treatment of invasive fungal disease in hematological patients (ProCAS Study)." 04/01/2012 - "The aim of this study was to assess the efficacy and safety of caspofungin for the prophylaxis and treatment of fungal infections, compared with other medications. " 04/01/2012 - "Caspofungin for prophylaxis and treatment of fungal infections in adolescents and adults: a meta-analysis of randomized controlled trials."

Related Drugs and Biologics

1.	Voriconazole (Vfend)
2.	Amphotericin B (Amphotericin)
3.	Echinocandins
4.	Fluconazole (Zonal)
5.	liposomal amphotericin B
6.	Antifungal Agents
7.	Micafungin (FK463)
8.	Anidulafungin
9.	posaconazole
10.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)

Related Therapies and Procedures

1.	Therapeutics
2.	Salvage Therapy
3.	Stem Cell Transplantation
4.	Drug Therapy (Chemotherapy)
5.	Liver Transplantation