Ringer's Lactate

A crystalloid solution that contains SODIUM CHLORIDE; SODIUM LACTATE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. It is used for FLUID THERAPY.

Also Known As:

Hartmann's Solution; Hartmanns Solution; Lactated Ringer's Solution; Lactated Ringers Solution; Ringer's, Lactated; Ringers Lactate; Lactate, Ringer's; Lactate, Ringers; Lactated Ringer Solution; Lactated Ringer's; Ringer's Solution, Lactated; Ringers Solution, Lactated

Networked: 1290 relevant articles (68 outcomes, 179 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Pharmaceutical Preparations
- Solutions: 41770
  - Isotonic Solutions: 65
    - Crystalloid Solutions: 1951
      - Ringer's Lactate: 1290

Experts

1.	Bland, Kirby I: 17 articles (08/2010 - 06/2003)
2.	Chaudry, Irshad H: 17 articles (08/2010 - 06/2003)
3.	Alam, Hasan B: 13 articles (01/2022 - 08/2002)
4.	Dubick, Michael A: 13 articles (01/2020 - 06/2006)
5.	Schreiber, Martin A: 11 articles (01/2021 - 06/2002)
6.	Choudhry, Mashkoor A: 11 articles (08/2010 - 07/2005)
7.	Horton, Jureta W: 11 articles (10/2007 - 04/2002)
8.	Chen, Xu-Lin: 10 articles (01/2019 - 05/2003)
9.	Martini, Wenjun Z: 10 articles (01/2014 - 05/2005)
10.	Holcomb, John B: 9 articles (01/2021 - 05/2003)

Related Diseases

1.	Hemorrhagic Shock 05/15/2015 - "CsA prolonged the survival time and increased the 24-h survival rate of traumatic hemorrhagic shock (31%, 56%, and 56% in 1, 5, and 10 mg/kg CsA group versus 25% in lactated Ringer solution group). " 11/01/2008 - "Male Sprague-Dawley rats were subjected to hemorrhagic shock and resuscitated with either lactated Ringer solution (RL) or HTS. " 10/01/2008 - "Animals underwent hemorrhagic shock (mean arterial pressure 35 +/- 5 mm Hg for 90 mins) and were resuscitated with shed blood and Ringer's lactate (2 hrs). " 08/01/2006 - "Eighty-one anesthetized Wistar rats (200-250 g) were randomly assigned to a first injury: (1) control-HS-no hemorrhagic shock/no reperfusion group, (2) HS/blood-HS/R with 25% shed blood, and (3) HS/blood + LR-HS/R with 25% of the shed blood + lactated Ringer's solution, 3x shed blood volume. " 05/01/2006 - "Lactated Ringer's solution and hypertonic saline improve survival in uncontrolled hemorrhagic shock in female rats in metestrus."
2.	Hemorrhage 08/01/2011 - "We explored the hypothesis that reduced Ringer's lactate (RL) volume restoration in hemorrhage is significantly improved by increasing its viscosity, leading to improved microvascular conditions. " 05/01/1993 - "To study this, rats (with or without heparinization prior to hemorrhage, 1 U/g body wt) were bled to and maintained at a mean arterial pressure of 40 mm Hg until 40% of maximal bleedout volume was returned in the form of lactated Ringer's solution (LR). " 02/01/2022 - "In contrast, three of 10 rabbits treated with RBC/PPP failed hemostasis, and no rabbits receiving lactated Ringer solution stopped bleeding or survived. " 01/01/2021 - "Mouse groups subjected to controlled hemorrhage for 90 minutes were (1) lactated Ringer solution (LR), (2) FDPlts, (3) fresh human Plts, (4) murine whole blood (WB), and (5) shams (only instrumented). " 11/01/2017 - "One hour after hemorrhage, animals were resuscitated using ALM, BHB/M, or P-188 followed by lactated Ringer's (LR, 15 mL/kg). "
3.	Wounds and Injuries (Trauma) 01/01/2016 - "Subsequently, the wound was sutured and mean arterial pressure was restored to baseline with lactated Ringer's infusion. " 12/01/1988 - "Infusion rates of up to 1,622 cc/minute (one liter in 37 seconds) of lactated Ringer's solution were achieved in this group of patients with a mean Trauma Score of 9.3 and a mean Injury Severity Score of 32.1. " 09/01/1998 - "To study this, rats underwent laparotomy (i.e., trauma induced) and were bled to and maintained at a mean arterial pressure of 40 mm Hg until 40% of the shed blood volume was returned in the form of Ringer's lactate. " 10/20/1997 - "To study this, rats underwent a 5-cm midline laparotomy (i.e., trauma-induced) and were bled to and maintained at a mean arterial pressure of 40 mm Hg until 40% of maximum bleed out volume was returned in the form of Ringer's lactate (RL). " 07/01/1997 - "To study this, midline laparotomy (i.e., trauma induction) was performed in the rats, and then the animals were bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of shed blood volume was returned in the form of Ringer's lactate. "
4.	Pancreatitis 10/01/2021 - "Aggressive intravenous hydration with Lactated Ringer's solution did not improve clinical outcome in mild acute pancreatitis but showed statistically significant improvement only in patients with obese status. " 01/01/2017 - "Early aggressive intravenous hydration with Lactated Ringer's solution hastens clinical improvement in patients with mild acute pancreatitis." 01/01/2022 - "Aggressive intravenous hydration protocol of Lactated Ringer's solution benefits patients with mild acute pancreatitis: A meta-analysis of 5 randomized controlled trials." 01/01/2020 - "This study aimed to compare a "nonaggressive" hydration versus an "aggressive" hydration using Hartmann's solution in patients with acute pancreatitis (AP) with more than 24 hours from disease onset. " 03/01/2017 - "The results of previous studies evaluating aggressive hydration with lactated Ringer solution for reducing the incidence of post-ERCP pancreatitis (PEP) are inconsistent. "
5.	Hypotension (Low Blood Pressure) 06/01/2006 - "This study does not support the use of 15 ml/kg Hartmann's solution to reduce the incidence of hypotension or postoperative morbidity in patients undergoing elective colonoscopy." 09/01/2022 - "On arrival to the emergency department (ED), he had received a total of 6 L of intravenous lactate Ringers, and vasopressors were initiated due to hypotension. " 07/01/2017 - "Fluid challenge with lactated Ringer's solution (15 mL kg-1 in 15 minutes) was administered in mechanically ventilated dogs (tidal volume 10 mL kg-1) with hypotension [mean arterial pressure (MAP) < 65 mmHg]. " 08/01/2015 - "All animals then received one 15-mL/kg bolus of Hextend, followed by lactated Ringer's solution for hypotension up to 100 mL/kg. Animals were monitored for 3 hours. " 03/01/2011 - "C57BL6 mice received controlled cortical impact followed by hemorrhagic hypotension (2 mL/100 g, mean arterial blood pressure ∼35-40 mm Hg) for 90 min. Mice were resuscitated (mean arterial blood pressure>50 mm Hg for 30 min) with lactated Ringer's, Hextend, or PNPH, and then shed blood was reinfused. "

Related Drugs and Biologics

1.	Solutions
2.	Saline Solution
3.	Dextrans (Dextran)
4.	Starch (Cornstarch)
5.	Colloids (Colloid)
6.	Hydroxyethyl Starch Derivatives (Pentastarch)
7.	HES 130-0.4
8.	Hemoglobins (Hemoglobin)
9.	Crystalloid Solutions
10.	Hypertonic Saline Solution

Related Therapies and Procedures

1.	Resuscitation
2.	Spinal Anesthesia
3.	Cesarean Section (Caesarean Section)
4.	Therapeutics
5.	Fluid Therapy (Oral Rehydration Therapy)