Transforming Growth Factor-beta Type II Receptor

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Also Known As:

Receptor, Transforming Growth Factor-beta Type II; TGF-beta Type II Receptor; TGF-beta Type II Receptors; TGFBR2; TbetaR-II Kinase; Transforming Growth Factor-beta Type II Receptors; Type II TGF-beta Receptor; Type II TGF-beta Receptors; Kinase, TbetaR-II; Receptor, Transforming Growth Factor beta Type II; TGF beta Type II Receptor; TGF beta Type II Receptors; TbetaR II Kinase; Transforming Growth Factor beta Type II Receptor; Transforming Growth Factor beta Type II Receptors; Type II TGF beta Receptor; Type II TGF beta Receptors

Networked: 887 relevant articles (17 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Moses, Harold L: 23 articles (01/2019 - 05/2003)
2.	Chytil, Anna: 15 articles (09/2014 - 11/2003)
3.	Grady, William M: 12 articles (01/2017 - 01/2002)
4.	Boileau, Catherine: 10 articles (12/2016 - 08/2004)
5.	Gebert, Johannes: 9 articles (10/2019 - 04/2003)
6.	Chai, Yang: 9 articles (04/2015 - 11/2003)
7.	Morisaki, Takayuki: 8 articles (02/2021 - 08/2004)
8.	Jondeau, Guillaume: 8 articles (12/2016 - 08/2004)
9.	Gorska, Agnieszka E: 8 articles (09/2014 - 05/2003)
10.	Matsumoto, Naomichi: 8 articles (12/2008 - 01/2004)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2021 - "In conclusion, our study identified a crucial role of lnc-MFAT1-miR-135a-Tgfbr2/Smad4 axis in skeletal muscle fibrosis, providing a promising treatment option against skeletal muscle fibrosis." 10/16/2018 - "Conclusions Myofibroblast-targeted knockdown of Tgfbr2 signaling resulted in reduced fibrosis and improved cardiac function, leading to improved probability of survival." 03/01/2023 - "In the present study we investigated the renal parenchymal cell senescence in fibrosis from the sight of posttranslational regulation and focused on Tgfbr2, the important gatekeeper for TGF-β1 downstream signaling. " 03/01/2023 - "Usp11 promotes the development of renal fibrosis by deubiquitinating Tgfbr2, reducing Tgfbr2 ubiquitination degradation, and then facilitating the activation of downstream senescent signaling pathway." 01/01/2021 - "Besides, the miR-135a-5p inhibition obviously promoted TGFβ-induced fibrosis in vitro via enhancing its target genes Tgfbr2/Smad4. "
2.	Neoplasms (Cancer) 01/01/2020 - "In conclusion, we greatly improved the in vitro and in vivo function of CAR T cells in TGF-β-rich tumor environments by knocking out endogenous TGFBR2 and propose a potentially new method to improve the efficacy of CAR T cell therapy for treating solid tumors." 05/01/2022 - "Our study reports the miR-485-3p/TGFBR2/ TGF-β signaling axis in tumor development of PC, suggesting miR-485-3p may be a potential target to develop therapeutic strategies against PC." 01/01/2022 - "The tumor cells used in this study carried mutations in Apc (A), Kras (K), Tgfbr2 (T), Trp53 (P), and Fbxw7 (F) in various combinations. " 01/01/2016 - "Further study showed that miR-17~92 inhibited the progression of CRC via suppressing tumor angiogenesis through targeting multiple tumor angiogenesis-inducing genes, TGFBR2, HIF1α, and VEGFA in vivo and in vitro. " 01/01/2014 - "However, larger scale primary studies are required to further evaluate the interaction of TGFBR2 G-875A polymorphism and cancer risk in specific cancer subtypes. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2012 - "One variant, TGFBR2 rs1078985, had highly consistent and significant associations with breast cancer risk among participants in both study stages, as well as promising results from in silico analysis. " 08/01/2014 - "This study is the first to show that these 5 susceptibility loci (8p12, 4q34.1/ADAM29, 2q14.2, 3p24.1/TGFBR2, and 16q12.2/FTO) correlate with breast cancer (overall and specific subtypes) in Chinese women, which has improved our understanding of the genetic basis of specific breast cancer subtypes. " 01/01/2018 - "In this study, we performed genomewide correlation analysis of TGFBR2 expression in a panel of 51 breast cancer cell lines and identified that MET is coregulated with TGFBR2. " 02/10/2015 - "Association with TGFBR2 rs1367610 but not IL12B variants replicated using BCAC Asian samples and the independent Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer Study and yielded a combined HR of 1.57 ((95% CI 1.28 to 1.94), P = 2.05 × 10⁻⁵) without study heterogeneity. " 07/01/2012 - "Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians."
4.	Liver Cirrhosis (Hepatic Cirrhosis) 07/20/2022 - "[Study of the negative regulation of transforming growth factor beta type II receptor to inhibit the occurrence and development of liver fibrosis with miR-217]." 01/01/2019 - "In conclusion, the results of the present study revealed that miR‑219 may regulate pro‑fibrotic markers by directly targeting the TGFBR2 gene and the miR‑219/TGFBR2 signaling pathway may be a potential therapeutic target for liver fibrosis." 01/01/2023 - "Depletion of Tgfbr2 in hepatocytes alleviates liver fibrosis and restores hepatic function in fibrotic mice." 07/20/2022 - "Conclusion: miR-217 regulates liver fibrosis by targeting TGFBR2, inhibits AngII-induced HSC activation, and slows down the process of liver fibrosis in CCl4 mice, suggesting that miR-217 may have an inhibitory effect on liver fibrosis. " 01/01/2022 - "In conclusion, the therapeutic benefit of F2 against liver fibrosis results from inhibition of c-Jun expression to reduce TGFBR2 and concomitant reduction of the responsiveness of hepatic stellate cells to TGF-β1. "
5.	Carcinogenesis 01/01/2022 - "Therefore, we generated an animal model to study how the loss of both TGFBR2 signaling impacts dMMR-driven intestinal tumorigenesis in vivo and explore the impact of the gut microbiota. " 01/01/2014 - "The present study was designed to clarify the role for TGF-β signaling in early thyroid carcinogenesis using the conditional Tgfbr2(floxE2/floxE2) knock-in mice, having 2 loxP sites at introns 1 and 2 of Tgfb2r gene. " 11/08/2001 - "These studies provide insight into the mechanism by which TGFBR2 and BAX genes become mutated during tumorigenesis. " 01/01/2021 - "Furthermore, we document that YAP/TAZ and EZH2 cooperate in lung tumorigenesis by transcriptionally repressing a specific subset of tumor suppressor genes, including TGFBR2. " 07/01/2019 - "These findings may point to mechanisms in which GDF15 exerts dual effect during carcinogenesis with regard to TGFBR2 expression."

Related Drugs and Biologics

1.	Transforming Growth Factor beta (TGF-beta)
2.	Proteins (Proteins, Gene)
3.	Transforming Growth Factors (Transforming Growth Factor)
4.	Transforming Growth Factor beta Receptors (TGF beta Receptors)
5.	MicroRNAs (MicroRNA)
6.	Antibodies
7.	Collagen
8.	Antisense Oligonucleotides
9.	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)
10.	p38 Mitogen-Activated Protein Kinases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation
3.	Mastectomy (Mammectomy)
4.	Therapeutics
5.	Ligation