Lycopene

A carotenoid and red pigment produced by tomatoes, other red fruits and vegetables, and photosynthetic algae. It is a key intermediate in the biosynthesis of other carotenoids, and has antioxidant, anti-carcinogenic, radioprotective, and anti-inflammatory properties.

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Networked: 1682 relevant articles (227 outcomes, 508 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Erdman, John W: 32 articles (01/2022 - 02/2002)
2.	Wang, Xiang-Dong: 27 articles (01/2022 - 06/2003)
3.	Clinton, Steven K: 26 articles (01/2022 - 02/2002)
4.	Kucuk, Omer: 18 articles (03/2018 - 02/2002)
5.	Giovannucci, Edward: 15 articles (11/2018 - 02/2002)
6.	Schwartz, Steven J: 13 articles (01/2019 - 02/2002)
7.	Sahin, Kazim: 13 articles (03/2018 - 01/2004)
8.	Liu, Chun: 12 articles (01/2021 - 06/2003)
9.	Hu, Miao-Lin: 12 articles (08/2017 - 09/2005)
10.	Sesso, Howard D: 11 articles (09/2014 - 07/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "Due to the heterogeneity of our results, further high-quality clinical trials with long-term duration are required to determine the efficacy of lycopene in patients with non-metastatic prostate cancer." 11/01/2022 - "Epidemiological evidence has shown that lycopene consumption may be effective in both the prevention and treatment of various diseases, particularly prostate cancer. " 01/01/2014 - "Lycopene extracted from tomato and other fruits or plants such as Gac, watermelon, pink grapefruit, pink guava, red carrot and papaya has been shown to be effective on prostate cancer prevention and treatment. " 05/01/2013 - "Is lycopene an effective agent for preventing prostate cancer?" 05/01/2007 - "Consistent with other recent publications, these results suggest that lycopene or tomato-based regimens will not be effective for prostate cancer prevention."
2.	Neoplasms (Cancer) 05/01/2023 - "The potent relation between lycopene intake and reduced incidence of a variety of cancers has an increasing interest. " 03/01/2016 - "An improved understanding of the mechanisms underlying the anticancer effects of lycopene may provide novel therapeutic targets for cancer treatment. " 01/01/1999 - "Epidemiological studies suggest protective effects of lycopene-rich foods on several types of cancer, including prostate and gastrointestinal tract. " 06/01/1998 - "Protective effects of a lycopene-rich diet on some types of cancer were suggested on the basis of epidemiological studies. " 12/03/2022 - "We identified 72 human and animal studies that were then analysed for endpoints such as cancer incidence, improvement in treatment outcomes, and the mechanisms of lycopene action. "
3.	Inflammation (Inflammations) 08/31/2023 - "According to the research mentioned, lycopene supplementation has significant promise for the treatment of illnesses marked by chronic inflammation and oxidative stress. " 03/01/2019 - "For the first time in literature we determined that, lycopene was significantly effective in prevention of augmented inflammation and oxidative stress on eye tissue associated with diabetes, as well as the tissue damage on optic nerve. " 01/01/2017 - "Thus, lycopene-rich extract from red guava has beneficial effect on acute inflammation, offering protection against the consequences of oxidative stress by downregulating inflammatory mediators and inhibiting gene expression involved in inflammation." 07/01/2009 - "Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. " 09/01/2014 - "In this review, we examined clinical trials comparing the efficacy of lycopene supplements with tomato products on intermediate CVD risk factors including oxidative stress, inflammation, endothelial function, blood pressure, and lipid metabolism. "
4.	Oral Submucous Fibrosis 12/01/2020 - "Efficacy of Lycopene in the Treatment of Oral Submucous Fibrosis: A Meta-analysis of Randomized Controlled Trials." 12/01/2020 - "The aim of this meta-analysis was to systematically evaluate the efficacy of lycopene in improving maximum mouth opening and other clinical symptoms in patients with oral submucous fibrosis (OSF). " 10/01/2020 - "To evaluate the efficacy of lycopene in the management of Oral Submucous Fibrosis (OSMF). " 10/01/2020 - "Efficacy of lycopene in management of Oral Submucous Fibrosis- A systematic review and meta-analysis." 02/01/2007 - "Efficacy of oral lycopene in the management of oral submucous fibrosis."
5.	Carcinogenesis 07/01/2011 - "Lycopene treatment significantly decreased the incidence of 4-NQO induced tongue carcinogenesis. " 07/01/2011 - "Results of the present study indicate that lycopene can exert protective effects against 4-NQO induced tongue carcinogenesis through reduction in cell proliferation and enhanced cellular adhesion, suggesting a new mechanism for the anti-invasive effect of lycopene. " 01/01/2022 - "We review the published studies evaluating the impact of tomatoes and/or lycopene in preclinical models of prostate carcinogenesis and tumorigenesis. " 12/01/2019 - "In this study, we investigated the effects of dietary lycopene on sub-acute and chronic ultraviolet B (UVB)-induced skin carcinogenesis in SKH-1 mice. " 06/01/2015 - "This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies. "

Related Drugs and Biologics

1.	Antioxidants
2.	Carotenoids (Carotene)
3.	Selenium
4.	Lutein
5.	beta Carotene (Betacarotene)
6.	Vitamin E
7.	Curcumin
8.	Enzymes
9.	Micronutrients
10.	Zeaxanthins

Related Therapies and Procedures

1.	Therapeutics
2.	Root Planing
3.	Radiotherapy
4.	Chemoprevention
5.	Complementary Therapies (Alternative Medicine)