Remifentanil (Ultiva)

A piperidine-propionate derivative and opioid analgesic structurally related to FENTANYL. It functions as a short-acting MU OPIOID RECEPTOR agonist, and is used as an analgesic during induction or maintenance of general anesthesia, following surgery, during childbirth, and in mechanically ventilated patients under intensive care.

Also Known As:

Networked: 2086 relevant articles (182 outcomes, 478 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wang, Guolin: 15 articles (01/2022 - 01/2013)
2.	Yu, Yonghao: 11 articles (04/2022 - 01/2013)
3.	Li, Yize: 11 articles (01/2022 - 01/2013)
4.	Zhang, Linlin: 11 articles (01/2022 - 01/2015)
5.	Zhang, Wei: 11 articles (11/2021 - 03/2012)
6.	Gu, Xiaoping: 11 articles (03/2017 - 12/2009)
7.	Ma, Zhengliang: 11 articles (03/2017 - 12/2009)
8.	Dahan, Albert: 10 articles (01/2022 - 06/2010)
9.	Wang, Chunyan: 10 articles (01/2022 - 01/2013)
10.	Irwin, Michael G: 10 articles (01/2019 - 10/2004)

Related Diseases

1.	Pain (Aches) 05/01/2009 - "Remifentanil is safe and highly effective for pain control during percutaneous transhepatic biliary drainage. " 04/01/2011 - "The decrease in pain scores in the epidural group was significantly greater than the remifentanil group at all time intervals. " 01/01/2017 - "Moments of incident pain were effectively treated in 6 patients requiring an extra bolus of remifentanil. " 01/01/2023 - "The response to moderately intense focal pressure in pain-related brain networks is effectively eliminated with safe remifentanil doses. " 05/01/2013 - "Continuous infusion of low-dose remifentanil is a safe and effective method for palliation of pain in epidural catheterization."
2.	Postoperative Pain 08/01/2000 - "Postoperative pain scores were significantly greater in the remifentanil group. " 09/01/2023 - "We aimed to assess the efficacy of intra-articular remifentanil in relieving postoperative pain after knee arthroscopy. " 07/28/2023 - "This study aimed to evaluate the impact of different remifentanil doses on chronic postsurgical pain after video-assisted thoracic surgery. " 04/01/2022 - "This study aimed to assess the effects of the intraoperative remifentanil dose on postoperative pain. " 11/01/2020 - "In the main study (n = 86), peak postoperative pain and intraoperative remifentanil consumption were lower in the pupillometry group (median [first to third quartile], 5 [4-6]; mean ± standard deviation [SD], 0.078 ± 0.019 μg·kg·minute) compared to the SPI group (7 [5-8] and 0.0130 ± 0.051 μg·kg·minute; P < .001), with the median difference in peak postoperative pain of -1 and its 95% confidence interval between -2 and -0.5. "
3.	Hyperalgesia 01/01/2022 - "The experimental investigations on the pathogenesis of remifentanil-induced hyperalgesia (RIH) have been primarily conducted, but the effective treatment of RIH remains unclear. " 12/01/2021 - "Supplemental administration of N2O may help to reduce remifentanil-induced hyperalgesia. " 10/01/2014 - "Selective GSK-3β inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 ± 23.51 vs 119 ± 14.74, P = 0.0027; 254 ± 23.51 vs 124 ± 9.35, P = 0.0032). " 11/30/2023 - "Remifentanil-induced hyperalgesia in healthy volunteers: a systematic review and meta-analysis of randomized controlled trials." 12/01/2021 - "This study aimed to investigate whether P2Y1R participates in nociceptive processing in the DRG and spinal cord in remifentanil-induced postoperative hyperalgesia. "
4.	Reperfusion Injury 01/01/2018 - "In conclusion, remifentanil preconditioning conferred liver protection against ischemia-reperfusion injury, which was mediated by the central vagal pathway." 04/22/2013 - "Remifentanil ameliorates intestinal ischemia-reperfusion injury." 11/01/2020 - "Remifentanil up-regulates HIF1α expression to ameliorate hepatic ischaemia/reperfusion injury via the ZEB1/LIF axis." 01/01/2019 - "Using the rodent models of hepatic ischemia reperfusion injury both in wild type and TLR4 knockout (TLR4 KO) mice, we found that remifentanil preconditioning could inhibit the expression of TLR4 and reduce the inflammatory response induced by HIRI in wild type but not in TLR4 KO mice. " 01/01/2019 - "Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury."
5.	Respiratory Insufficiency (Respiratory Failure) 04/13/2017 - "More research is needed on maternal and neonatal safety outcomes (maternal apnoea and respiratory depression, Apgar score) and on the optimal mode and regimen of remifentanil administration to provide highest efficacy with reasonable adverse effects for mothers and their newborns." 03/28/2023 - "During remifentanil infusion, there were no significant differences in the incidence of respiratory depression and the distribution of observer's assessment of alertness/sedation (OAA/S) scores between the 2 groups (both P>0.05), and there were no changes in mental status and airway support in the patients of the 2 groups. " 01/01/2023 - "Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs." 10/01/2021 - "Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex." 01/01/2021 - "Remifentanil TCI is a suitable protocol for procedural sedation, but respiratory depression is a permanent concern. "

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Dexmedetomidine
3.	Sevoflurane (Ultane)
4.	Opioid Analgesics (Opioids)
5.	Fentanyl (Sublimaze)
6.	Sufentanil (Sufenta)
7.	Ketamine
8.	Lidocaine (Xylocaine)
9.	Morphine (MS Contin)
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Anesthesia
2.	Analgesia
3.	General Anesthesia
4.	Intravenous Anesthesia
5.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)