Sodium Sulfate Cotransporter

A multi-pass protein that consists of 13 transmembrane helices. It is expressed primarily by renal epithelial cells and functions as a co-transporter of sodium and sulfate, to mediate sulfate reabsorption in the kidney.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Choyce, Allison: 1 article (02/2010)
2.	Chuang, Christine: 1 article (02/2010)
3.	Dawson, Paul Anthony: 1 article (02/2010)
4.	Leggatt, Graham Robert: 1 article (02/2010)
5.	Markovich, Daniel: 1 article (02/2010)
6.	Whitelock, John: 1 article (02/2010)
7.	Dawson, P A: 1 article (07/2009)
8.	Gardiner, B: 1 article (07/2009)
9.	Grimmond, S: 1 article (07/2009)
10.	Huxley, S: 1 article (07/2009)

Related Diseases

1.	Colitis 07/01/2009 - "In this study, the hyposulfataemic NaS1 sulfate transporter null (Nas1(-/-)) mice were used to investigate the physiological consequences of disturbed sulfate homeostasis on (1) intestinal sulfomucin content and mRNA expression; (2) intestinal permeability and proliferation; (3) dextran sulfate sodium (DSS)-induced colitis; and (4) intestinal barrier function against the bacterial pathogen, Campylobacter jejuni. "
2.	Neoplasms (Cancer) 02/01/2010 - "Enhanced tumor growth in the NaS1 sulfate transporter null mouse."
3.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2001 - "Sulfate homeostasis, NaSi-1 cotransporter, and SAT-1 exchanger expression in chronic renal failure in rats."
4.	Cysts 09/01/1997 - "At early stages of cyst development, alkaline phosphatase, aquaporin-1, NaSi-1 cotransporter, and Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) were expressed normally. "
5.	Ototoxicity 03/01/2023 - "Sodium thiosulfate reduces the risk of ototoxicity by interacting directly with cisplatin to produce inactive platinum species, as well as by causing intracellular effects (such as increasing antioxidant glutathione levels and inhibition of oxidative stress) after entering the cells through the sodium sulfate cotransporter 2. In September 2022, sodium thiosulfate received its first approval in the USA for reducing the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumours. "

Related Drugs and Biologics

1.	Sulfates (Sulfates, Inorganic)
2.	Dextran Sulfate
3.	Messenger RNA (mRNA)
4.	sulfomucin
5.	Platinum
6.	Glutathione (Reduced Glutathione)
7.	Cisplatin (Platino)
8.	Antioxidants
9.	Alkaline Phosphatase
10.	Adenosine Triphosphatases (ATPase)