Sulfate Transporters

Highly conserved families of transmembrane anion transporters that occur in both prokaryotes and eukaryotes. In humans, they are expressed by epithelial cells in a variety of tissues and participate in diverse physiologic functions such as cell motility and regulating the composition and acidity of body fluids. Some Slc13 family proteins function as sodium ion-coupled co-transporters of sulfate and other anions.

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Networked: 105 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rossi, Antonio: 6 articles (05/2014 - 07/2003)
2.	Superti-Furga, Andrea: 6 articles (07/2010 - 10/2003)
3.	Cetta, Giuseppe: 4 articles (07/2010 - 07/2003)
4.	Nishimura, Gen: 4 articles (04/2010 - 06/2006)
5.	Forlino, Antonella: 3 articles (07/2010 - 03/2005)
6.	Gualeni, Benedetta: 3 articles (07/2010 - 03/2005)
7.	Karniski, Lawrence P: 3 articles (05/2010 - 10/2004)
8.	Ikegawa, Shiro: 3 articles (04/2010 - 06/2006)
9.	Unger, Sheila: 3 articles (04/2010 - 06/2008)
10.	Hästbacka, J: 3 articles (12/2008 - 04/2000)

Related Diseases

1.	Diastrophic dysplasia 11/01/2014 - "Mutations of the diastrophic dysplasia sulfate transporter (also known as solute carrier family 26 member 2) were encountered. " 01/01/2014 - "Mutations in diastrophic dysplasia sulfate transporter gene (DTDST) result in recessive MED. To investigate the possible gene mutation in a recessive MED patient. " 12/01/2010 - "Mutations in diastrophic dysplasia sulfate transporter (DTDST) cause a spectrum of autosomal recessive chondrodysplasias. " 04/01/2010 - "Molecular testing of the diastrophic dysplasia sulfate transporter (DTDST) gene was performed on six patients and no mutations were detected. " 01/01/2009 - "Mutations in the diastrophic dysplasia sulphate transporter (dtdst) gene causes different forms of chondrodysplasia in the human. "
2.	Achondrogenesis 09/15/1997 - "Parallel in vitro studies in a patient with achondrogenesis 1B indicated that the severity of the clinical phenotype seems to be correlated to the residual activity of the sulfate transporter. " 08/01/1999 - "We have observed over 25 different mutations in the diastrophic dysplasia sulphate transporter gene (DTDST) in association with the recessive disorders achondrogenesis 1B, atelosteogenesis 2, and diastrophic dysplasia. " 08/01/2013 - "Mutations in solute carrier family 26 (sulfate transporter), member 2 (SLC26A2) gene result in a spectrum of autosomal recessive chondrodysplasias that range from the mildest recessive form of multiple epiphysial dysplasia (rMED) through the most common diastrophic dysplasia (DTD) to lethal atelosteogenesis type II and achondrogenesis IB. " 03/15/2005 - "Mutations in the diastrophic dysplasia sulfate transporter (DTDST or SLC26A2) cause a family of recessively inherited chondrodysplasias including, in order of decreasing severity, achondrogenesis 1B, atelosteogenesis 2, diastrophic dysplasia (DTD) and recessive multiple epiphyseal dysplasia. " 03/10/1997 - "Furthermore, in both achondrogenesis and colon cancer, the reduced ability to sulphate proteoglycans is due to genetic defects in cellular sulfate transporters. "
3.	Dehydration (Water Stress) 10/01/2010 - "We also found increased expression of a sulfate transporter gene in roots from early water stress onwards. " 07/01/2010 - "The expression of a sulphate transporter gene was also analysed and it was found that it had increased in the elongation region of roots from the early to the later stages of water stress. " 06/01/2017 - "In this study, poplar plants (Populus × canescens) were exposed to water stress to investigate xylem sap sulfate and ABA, stomatal conductance, and sulfate transporter (SULTR) expression. "
4.	Lung Diseases (Lung Disease) 01/01/2017 - "Through genetic studies of lung diseases, SLC26A9, a member of the solute carrier 26 family of anion transporters, has emerged as a promising target to bypass CFTR dysfunction. "
5.	Achondrogenesis type 1B 02/01/1996 - "Together with our recent observation that a third even more severe chondrodysplasia, achondrogenesis type IB, is also caused by mutations in DTDST, these results demonstrate a phenotypic series of three chondrodysplasias of increasing severity caused by lesions in a single sulfate-transporter gene. " 01/01/1996 - "Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene." 10/01/2001 - "Thus, in achondrogenesis type IB: (1) a complex derangement in cartilage matrix assembly lies downstream of the deficient sulfate transporter activity; (2) the severely impaired decorin deposition participates in the changes in matrix organization with lack of development of normal interterritorial matrix; and (3) this change determines the lack of the necessary structural substrate for proper endochondral bone formation and explains the severe skeletal phenotype." 10/01/2001 - "Achondrogenesis type IB is a lethal osteochondrodysplasia caused by mutations in the diastrophic dysplasia sulfate transporter gene. " 10/01/1998 - "Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene have been associated with a family of chondrodysplasias that includes diastrophic dysplasia (DTD), atelosteogenesis type 2 (AO2) and the lethal condition achondrogenesis type 1B (ACG1B). "

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)
2.	Sulfates (Sulfates, Inorganic)
3.	Sulfur
4.	Anions
5.	Sodium Fluoride (Ossin)
6.	Amino Acids
7.	Proteoglycans (Proteoglycan)
8.	Proteins (Proteins, Gene)
9.	Sulfate Transporters
10.	Messenger RNA (mRNA)