Rapamycin-Insensitive Companion of mTOR Protein

An adaptor protein subunit of MTORC2 COMPLEX. It functions as a structural component and is phosphorylated by RIBOSOMAL PROTEIN S6 KINASES, integrating signals for cell growth and proliferation, especially during embryonic development.

Also Known As:

RICTOR Protein; Rapamycin Insensitive Companion of mTOR Protein

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cao, Rui-Zhen: 1 article (01/2021)
2.	Cheng, Rui: 1 article (01/2021)
3.	Deng, Jing: 1 article (01/2021)
4.	Guo, Shui-Long: 1 article (01/2021)
5.	Jiang, Hai-Yan: 1 article (01/2021)
6.	Li, Peng: 1 article (01/2021)
7.	Liu, Juan: 1 article (01/2021)
8.	Liu, Si: 1 article (01/2021)
9.	Min, Li: 1 article (01/2021)
10.	Shao, Chuan: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2017 - "Overexpression of Rictor protein in colorectal cancer is correlated with tumor progression and prognosis." 01/01/2023 - "A high level of UBXN2A in patient-derived xenografts and tumor organoids decreases Rictor protein and suppresses the mTORC2 pathway. " 01/01/2021 - "Rapamycin-insensitive companion of mammalian target of rapamycin (Rictor) protein is a core subunit of mammalian target of rapamycin complex 2, and is associated with cancer progression. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 10/26/2023 - "Rictor protein levels in cardiac tissues from human ischemic heart disease patients were significantly decreased relative to non-ischemic controls. "
3.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2017 - "Overexpression of Rictor protein in colorectal cancer is correlated with tumor progression and prognosis."
4.	Neoplasm Metastasis (Metastasis) 05/01/2011 - "mTOR, Raptor, and Rictor protein levels were also significantly elevated in primary CRCs (stage IV) and their matched distant metastases compared with normal colon. "
5.	Memory Disorders (Memory Loss) 01/01/2021 - "ShRNA-induced knockdown of Rictor protein in the hippocampus of both Ctnnd2-KO mice and wild-type mice exacerbated spatial learning and memory deficits but did not affect their autism-like behaviors. "

Related Drugs and Biologics

1.	TOR Serine-Threonine Kinases
2.	Small Interfering RNA (siRNA)
3.	Sirolimus (Rapamycin)
4.	Messenger RNA (mRNA)
5.	Mechanistic Target of Rapamycin Complex 2
6.	Calcibiotic Root Canal Sealer