Disks Large Homolog 4 Protein

A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

Also Known As:

Networked: 94 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Guang-Yi: 12 articles (12/2009 - 06/2003)
2.	Pei, Dong-Sheng: 4 articles (12/2009 - 08/2004)
3.	Zhang, G-Y: 3 articles (09/2013 - 09/2008)
4.	Hou, Xiao-Yu: 3 articles (09/2012 - 06/2003)
5.	Sun, Ya-Feng: 3 articles (12/2009 - 08/2004)
6.	Zong, Yan-Yan: 3 articles (12/2009 - 06/2003)
7.	Johns, Roger A: 2 articles (01/2022 - 11/2008)
8.	Clemmensen, Louise S: 2 articles (11/2021 - 11/2021)
9.	Strømgaard, Kristian: 2 articles (11/2021 - 11/2021)
10.	Vistrup-Parry, Maria: 2 articles (11/2021 - 11/2021)

Related Diseases

1.	Cognitive Dysfunction 01/01/2023 - "CK improved cognitive impairment and increased postsynaptic density protein 95 and synaptophysin expression levels in mice with SCOP-induced cognitive dysfunction. " 12/01/2014 - "Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment." 01/01/2020 - "In the present study, treatment with Fer-1 blocked the activation of P38 MAPK, which resulted in an increased expression of synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95) in the hippocampus of rats with KA-induced TLE, hence, ameliorating their cognitive impairment. " 01/01/2022 - "The authors hypothesized that activation of protein kinase-G by the components of nitric oxide (NO) signaling pathway constitutes a mechanism that prevents loss of early dendritic spines and synapse in neurons and cognitive impairment in mice in response to disruption of PDZ2 domain of the PSD-95 protein. " 10/15/2022 - "This study aimed to investigate the therapeutic potential of miR-34c antagomir on cognitive dysfunction induced by streptozocin (STZ), considering postsynaptic density protein 95 (PSD-95) and mammalian target of rapamycin expression (mTOR). "
2.	Pain (Aches) 11/01/2008 - "Our results indicate that by disrupting NMDAR/PSD-95 protein interactions, the cell-permeable fusion peptide Tat-PSD-95 PDZ2 provides a new target and approach for chronic inflammatory pain therapy." 10/01/2018 - "The present study investigated the possible contribution of a protein-protein interaction between postsynaptic density protein 95 (PSD-95) and neuronal nitric oxide synthase (nNOS) to thalamic pain in mice. " 07/16/2015 - "ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. "
3.	Ischemic Stroke 12/05/2023 - "Disrupting postsynaptic density protein 95 (PSD95)-nNOS protein-protein interaction (PPI) has been proposed as a potential therapeutic strategy for ischemic stroke without incurring the unwanted side effects of direct NMDAR antagonism. " 12/01/2020 - "ZL006 is shown to reduce over-produced nitric oxide and oxidative stress in ischemic stroke by interrupting the interaction of neuronal nitric oxide synthase and postsynaptic density protein 95. " 06/01/2013 - "Meantime, we found that the expression of synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95), two structural markers of synapses in ischemic stroke model were inhibited by NO(2) inhalation; and so it was with the key proteins mediating long-term potentiation (LTP), the major form of synaptic plasticity. " 07/16/2015 - "ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. " 03/01/2018 - "Therefore, to further explore the characteristics and mechanisms of blood-brain barrier (BBB) damage during cerebral ischemic stroke, we used a pMCAO rat model to define dynamic changes in BBB permeability within 120 h after ischemia in order to examine the expression levels of the TJ proteins claudin-5 and occludin and the synaptic proteins synaptophysin (SYP) and postsynaptic density protein 95 (PSD95). "
4.	Demyelinating Diseases (Demyelinating Disease) 01/01/2021 - "Intragastric administration of CIG for 2 months improved locomotor activity; alleviated neuronal loss and demyelination; increased the expression of synaptophysin, postsynaptic density protein 95, and AMPA receptor subunit 1; elevated the levels of soluble APPα fragment and disintegrin and metalloproteinase 10 (ADAM10); and decreased the levels of RIPK1, p-MLKL, and MLKL in the brain of young and aged SAMP8 mice. "
5.	Brain Injuries (Brain Injury) 10/01/2018 - "Consistent with our previous findings, we found that treatment with l-Cysteine after HI reduced early brain injury, improved behavioral deficits and synaptic damage, effects which were associated with an up-regulation of synaptophysin and postsynaptic density protein 95 expression in the lesioned cortex. "

Related Drugs and Biologics

1.	Synaptophysin
2.	Proteins (Proteins, Gene)
3.	AMPA Receptors (AMPA Receptor)
4.	Sirtuin 2
5.	Metalloproteases (Metalloproteinases)
6.	Disintegrins
7.	Cysteine (L-Cysteine)
8.	Caffeine (No Doz)
9.	2- ((1H- benzo(d)(1,2,3)triazol- 5- ylamino)methyl)- 4,6- dichlorophenol
10.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Acupuncture Points (Acupuncture Point)
3.	Therapeutics
4.	Anesthesia