SAM Domain and HD Domain-Containing Protein 1

A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).

Also Known As:

Networked: 19 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kim, Baek: 3 articles (01/2022 - 01/2017)
2.	Diaz-Griffero, Felipe: 3 articles (10/2021 - 01/2017)
3.	Kim, Dong-Hyun: 2 articles (01/2022 - 10/2021)
4.	Oo, Adrian: 2 articles (01/2022 - 10/2021)
5.	Schinazi, Raymond F: 2 articles (01/2022 - 10/2021)
6.	Shepard, Caitlin: 2 articles (01/2022 - 10/2021)
7.	Herold, Nikolas: 2 articles (01/2021 - 10/2018)
8.	Medeiros, L Jeffrey: 2 articles (01/2021 - 10/2018)
9.	Rassidakis, George Z: 2 articles (01/2021 - 10/2018)
10.	Xagoraris, Ioanna: 2 articles (01/2021 - 10/2018)

Related Diseases

1.	Infections 12/01/2022 - "In the present report, we demonstrate that the HCMV UL24 product interacts with the SAMHD1 protein during infection based on mass spectrometry (MS) data and immunoprecipitation assay. " 11/16/2022 - "Furthermore, depletion of SAM domain and HD domain-containing protein 1 (SAMHD1), a restriction factor that blocks PERV-A/C infection at the level of reverse transcription in these myeloid cells, had no significant effect on the CXCL10 induction level. " 11/15/2019 - "Infection of human DCs with MVA-vpx decreased SAMHD1 protein amounts, enabling MVA DNA replication and expression of late viral genes. " 01/01/2017 - "Additionally, the SAMHD1 protein has been shown to prevent efficient HIV-1 infection of macrophages, dendritic cells, and resting CD4+ T cells. " 06/01/2015 - "SAMHD1 (SAM domain- and HD domain-containing protein 1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T-cells. "
2.	Neoplasms (Cancer) 10/01/2021 - "This study suggests that the loss of SAMHD1 dNTPase activity induced by R366 mutations can mechanistically contribute to the elevated dNTP levels commonly found in cancer cells." 01/01/2020 - "SAM domain- and HD domain-containing protein 1 (SAMHD1) is a cellular enzyme which is responsible for blocking replication in viruses and participates in the progression of many cancers. " 10/19/2018 - "To determine whether SAMHD1 limits ara-C efficacy during induction or consolidation therapy, SAMHD1 protein levels were assessed in two patient cohorts of de novo AML from The University of Texas MD Anderson Cancer Center (USA) and the National University Hospital (Singapore), respectively, using immunohistochemistry and tissue microarrays. " 01/01/2023 - "We further demonstrate that de-ubiquitinating enzyme USP7 interacts with SAMHD1 and de-ubiquitinates it at lysine 421, thus stabilizing SAMHD1 protein expression for further interaction with CtIP for DDR, which promotes tumor cell survival under genotoxic stress. "
3.	Leukemia 01/01/2022 - "Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation. "
4.	Hodgkin Disease (Hodgkin's Disease) 01/01/2021 - "The expression patterns and prognostic significance of sterile alpha motif and HD domain-containing protein 1 (SAMHD1) protein in the neoplastic Hodgkin and Reed Sternberg (HRS) cells of Hodgkin lymphoma (HL) were investigated in a cohort of 154 patients with HL treated with standard regimens. "
5.	Brain Diseases (Brain Disorder) 01/01/2017 - "Mutations in the human SAMHD1 gene are known to correlate with the development of the Aicardi-Goutières syndrome (AGS), which is an inflammatory encephalopathy that exhibits neurological dysfunction characterized by increased production of type I interferon (IFN); this evidence has led to the concept that the SAMHD1 protein negatively regulates the type I IFN response. "

Related Drugs and Biologics

1.	Dynamins (Dynamin)
2.	GTP Phosphohydrolases (GTPases)
3.	Viral Proteins
4.	Carrier Proteins (Binding Protein)
5.	Bone Marrow Stromal Antigen 2
6.	Proteins (Proteins, Gene)
7.	Interleukin-15 (Interleukin 15)
8.	Ribonucleases (Ribonuclease)
9.	Lysine (L-Lysine)
10.	Interferon Type I

Related Therapies and Procedures

1.	Therapeutics