Inhibitor of Growth Protein 1

A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Reduced expression and chromosomal rearrangements of the ING1 gene are associated with different cancers including HEAD AND NECK NEOPLASMS.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Riabowol, Karl: 2 articles (06/2014 - 01/2010)
2.	Du, Min: 1 article (01/2017)
3.	Fu, Xing: 1 article (01/2017)
4.	Wang, B: 1 article (01/2017)
5.	Zhu, Mei-Jun: 1 article (01/2017)
6.	Chen, Jie: 1 article (06/2014)
7.	Jirik, Frank: 1 article (06/2014)
8.	Klimowicz, Alexander: 1 article (06/2014)
9.	Magliocco, Anthony: 1 article (06/2014)
10.	Salazar, Carolina: 1 article (06/2014)

Related Diseases

1.	Glioma (Gliomas) 06/01/2003 - "66 (94.3%) and 62 (88.6%) out of 70 gliomas expressed ING1 mRNA and p33(ING1) protein respectively. " 01/01/2010 - "Hence, the goal of our present study was to investigate whether TSA affects ING1 protein expression and also whether modulating ING1 levels affects TSA-induced apoptosis in malignant glioma cells that contain deficient p53 function and inactive pl4(ARF)/p16(INK4a) signaling. " 06/01/2003 - "The expressions of ING1 mRNA and p33(ING1) protein, hTERT mRNA and protein, and hTP1 mRNA and protein in seventy human glioma specimens with different malignant grades were studied using in situ hybridization and immunohistochemistry. "
2.	Carcinogenesis 06/01/2001 - "Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis."
3.	Neoplasms (Cancer) 02/01/2013 - "Here we show that the tumor suppressor inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation. " 10/03/2011 - "ING1 protein is a tumor suppressor which plays significant roles in multiple cellular activities. " 07/18/2011 - "Interestingly, ING1 protein levels increase in replicative senescent cells, latter representing an efficient pathway to inhibit cancer proliferation. " 01/01/2017 - "RA induces the partnering between retinoic acid receptor (RAR) and tumor suppressor inhibitor of growth protein 1 (ING1), which prevents the formation of GADD45A and ING1 complex necessary for locus-specific Zfp423 DNA demethylation. "
4.	Breast Neoplasms (Breast Cancer) 06/30/2014 - "Our data show that ING1 protein levels are downregulated in breast cancer and for the first time, we show that altering their levels regulates metastasis in vitro and in vivo, which indicates that ING1 may have a therapeutic role for inhibiting metastasis of breast cancer. " 04/18/2023 - "Subsequent amplified luminescence proximity homogeneous assay-linked immunosorbent assay using recombinant ING1 protein showed that the serum levels of anti-ING1 antibodies were increased not only in patients with CRC but also in those with esophageal cancer (EC), gastric cancer (GC), breast cancer (BrC), and pancreatic cancer (PC) compared with those of healthy donors (HDs). "
5.	Stomach Neoplasms (Stomach Cancer) 04/18/2023 - "Subsequent amplified luminescence proximity homogeneous assay-linked immunosorbent assay using recombinant ING1 protein showed that the serum levels of anti-ING1 antibodies were increased not only in patients with CRC but also in those with esophageal cancer (EC), gastric cancer (GC), breast cancer (BrC), and pancreatic cancer (PC) compared with those of healthy donors (HDs). "

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase Inhibitor p16
2.	theasinensin A
3.	Retinoic Acid Receptors (Retinoic Acid Receptor)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Immunosorbents
7.	Antibodies