Nectins

A family of calcium-independent cell adhesion molecules of the immunoglobulin superfamily. They are expressed by most cell types and mediate both homotypic and heterotypic cell-cell adhesion. Nectins function in a variety of morphogenetic and developmental processes that include organogenesis of the eye, ear, tooth, and cerebral cortex; they also play roles in viral infection and cell proliferation.

Also Known As:

CD111 Antigen; CD112 Antigen; CD113 Antigen; Herpesvirus Entry Mediator C; HevC Protein; Human Poliovirus Receptor Related 1; Nectin; Nectin-1; Nectin-1delta; Nectin-2; Nectin-2alpha; Nectin-2delta; Nectin-2gamma; Nectin-3; Nectin1delta; PVRL1; Poliovirus Receptor-Related Protein 1; Prr1 Protein; Antigen, CD111; Antigen, CD112; Antigen, CD113; Nectin 1; Nectin 1delta; Nectin 2; Nectin 2alpha; Nectin 2delta; Nectin 2gamma; Nectin 3; Poliovirus Receptor Related Protein 1

Networked: 318 relevant articles (6 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takai, Yoshimi: 24 articles (01/2022 - 06/2002)
2.	Lopez, Marc: 11 articles (01/2022 - 05/2004)
3.	Krummenacher, Claude: 9 articles (01/2019 - 03/2002)
4.	Cohen, Gary H: 9 articles (02/2008 - 03/2002)
5.	Eisenberg, Roselyn J: 9 articles (02/2008 - 03/2002)
6.	Ono, Etsuro: 8 articles (01/2019 - 01/2004)
7.	Shukla, Deepak: 8 articles (04/2013 - 10/2004)
8.	Miyoshi, Jun: 8 articles (02/2012 - 04/2005)
9.	Kopp, Sarah J: 7 articles (09/2015 - 10/2009)
10.	Mizutani, Kiyohito: 6 articles (01/2022 - 10/2011)

Related Diseases

1.	Infections 01/01/2020 - "Based on studies of the expression of the receptors nectin-1 and HVEM, we suggest that the decreasing number of nectin-1-expressing fibroblasts leads to a delayed onset of infection in the dermis from aged compared to juvenile mice. " 09/01/2015 - "Ex vivo infection studies reveal nectin-1 as the primary receptor in epidermis, whereas HVEM has a more limited role. " 01/01/2014 - "Chlamydial infection studies in nectin-1 knockdown (NKD) HeLa cell lines support this hypothesis. " 01/13/2012 - "Previous studies from our own and other labs reported the surprising finding that the soluble V domain of the herpes simplex virus type 1 (HSV-1) entry receptor nectin-1 can both block HSV infection of receptor-bearing cells and mediate infection of receptor-deficient cells. " 01/01/2012 - "This study was undertaken to uncover the relative significance of nectin-1 as an entry receptor in corneal infection and HSV-1 spread to the trigeminal ganglia (TG), a site important for HSV-1 latency and recurrent corneal infection. "
2.	Neoplasms (Cancer) 11/02/2023 - "This study aimed to evaluate the expression of specific nectins in CRC tumors, explore their association with clinicopathological factors, and ascertain their potential as prognostic indicators for CRC patients post-resection. " 04/01/2023 - "The aim of the present study was to evaluate the expression of Nectin-2 and Nectin-4 in glial tumors of different grades, and to assess their prognostic value. " 06/12/2013 - "To determine the expression of Nectin-2 in cancer tissues and cancer cell lines, we performed gene expression profile analysis, immunohistochemistry studies, and flow cytometry analysis. " 11/02/2023 - "Notably, tumors in the right colon were statistically more likely to express nectin-2 compared to those in the left. " 11/02/2023 - "Tumor specimens were re-evaluated to determine nectin expression using immunohistochemistry. "
3.	Ovarian Neoplasms (Ovarian Cancer) 09/01/2014 - "The diagnostic efficacy of nectin 4 expression in ovarian cancer patients." 01/01/2018 - "In our previous study, we have demonstrated that Nectin-2 is over-expressed in breast and ovarian cancer tissues by using gene expression analysis and immunohistochemistry. " 06/12/2013 - "In the present study, we found that Nectin-2 was over-expressed in clinical breast and ovarian cancer tissues by using gene expression profile analysis and immunohistochemistry studies. " 10/15/2022 - "Nectin-2, which is overexpressed in ovarian cancer, is a known immune checkpoint that deregulates immune cell function. " 06/01/2019 - "Herein, we investigated Nectin-2 in ovarian cancer patients and in cell culture. "
4.	Paraproteinemias (Monoclonal Gammopathy) 01/01/2020 - "Here we analyzed the expression of TIGIT and its ligands poliovirus receptor (PVR) and nectin-2 in the bone marrow (BM) of patients with monoclonal gammopathies and the efficacy of TIGIT blockade activating antimyeloma immunity. "
5.	Colorectal Neoplasms (Colorectal Cancer) 11/02/2023 - "Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study." 01/01/2019 - "The aim of the present study was to assess Nectin-1 expression patterns in colorectal cancer and to investigate its clinical significance. " 02/01/2016 - "The objective of this study was to evaluate the serum levels of nectin-2 with regard to diagnostic, predictive and prognostic value in colorectal cancer (CRC) patients. " 01/01/2019 - "Nectin-1 expression in colorectal cancer is associated with a significantly worse 3-year progression-free survival identifying therefore a group of patients with high risk for early disease recurrence." 01/01/2019 - "Nectin-1 was strongly expressed in the cytoplasm of colorectal cancer cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	poliovirus receptor
3.	Ligands
4.	Biomarkers (Surrogate Marker)
5.	Small Interfering RNA (siRNA)
6.	Fc Receptors (Fc Receptor)
7.	Collagen
8.	Nectins
9.	Interferons
10.	Cell Adhesion Molecules

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Molecular Targeted Therapy
4.	Cystectomy