Apolipoprotein L1

An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .

Also Known As:

Networked: 228 relevant articles (3 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Freedman, Barry I: 35 articles (01/2021 - 09/2010)
2.	Kopp, Jeffrey B: 19 articles (01/2022 - 09/2010)
3.	Pollak, Martin R: 17 articles (01/2022 - 09/2010)
4.	Divers, Jasmin: 16 articles (01/2021 - 11/2011)
5.	Langefeld, Carl D: 14 articles (03/2020 - 09/2010)
6.	Friedman, David J: 13 articles (01/2022 - 09/2010)
7.	Winkler, Cheryl A: 13 articles (01/2022 - 09/2010)
8.	Bowden, Donald W: 11 articles (03/2020 - 09/2010)
9.	Ma, Lijun: 11 articles (03/2020 - 11/2011)
10.	Hicks, Pamela J: 11 articles (01/2020 - 11/2011)

Related Diseases

1.	Chronic Renal Insufficiency 04/01/2023 - "Diet, chronic kidney disease (CKD), and Apolipoprotein L1 (APOL1) (DCA) Study is examining the role of dietary factors in CKD progression and APOL1 nephropathy. " 01/01/2022 - "According to observational studies, two polymorphisms in the apolipoprotein L1 (APOL1) gene have been linked to an increased risk of chronic kidney disease (CKD) in Africans. " 12/05/2013 - "In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. " 11/04/2023 - "People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. " 06/16/2023 - "Apolipoprotein L1 (APOL1) high-risk genotypes are associated with increased risk of chronic kidney disease (CKD) in people of West African ancestry. "
2.	Lupus Nephritis 01/01/2016 - "As almost 80% of the study population was made up of patients with FSGS and lupus nephritis, it remains to be determined by further studies among our patients, the role that Apolipoprotein L1 (APOL 1) gene mutation will play in the etiology of renal diseases in Nigeria." 01/01/2020 - "Apolipoprotein L1 gene (APOL1) G1 and G2 renal risk alleles (RRA) are associated with endstage renal disease in blacks with lupus nephritis (LN). " 01/01/2020 - "Effect of a Single Apolipoprotein L1 Gene Nephropathy Variant on the Risk of Advanced Lupus Nephritis in Brazilians." 03/01/2017 - "Genome-wide association studies have identified a substantial signal at 22q13, now assigned to variation at apolipoprotein L1 (APOL1), which has associated with progressive nondiabetic nephropathy, cardiovascular disease, and many immune-associated renal diseases, including lupus nephritis. " 11/01/2018 - "Discovery of the apolipoprotein L1 gene (APOL1) association with focal segmental glomerulosclerosis, human immunodeficiency virus (HIV)-associated nephropathy, lupus nephritis, sickle cell nephropathy, and solidified glomerulosclerosis, as well as more rapid failure of transplanted kidneys from donors with APOL1 renal-risk genotypes, has improved our understanding of nondiabetic nephropathy. "
3.	Infections 01/01/2023 - "Two heterozygous missense variants (G1 and G2) of Apolipoprotein L1 (APOL1) found in individuals of recent African ancestry can attenuate the severity of infection by some forms of Trypanosoma brucei. " 01/01/2021 - "COVID-19-associated collapsing glomerulopathy (COVAN) is seen almost exclusively in patients with apolipoprotein L1 high-risk genotypes with no evidence of direct infection of the kidney by SARS-CoV-2. " 04/12/2016 - "Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection." 01/01/2016 - "Trypanosoma evansi, the causative agent of surra, is pathogenic to a wide variety of wild and domestic animals, including equines, camels, goats, sheep, cattle, buffaloes, pigs, dogs, tigers, elephants etc. The infection is mainly restricted to animals but ability to infect human beings has also been reported due to the lack of efficient apolipoprotein L 1. The parasite is mechanically transmitted by blood-sucking flies such as Tabanus and Stomoxys species. " 08/26/2015 - "Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). "
4.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/01/2022 - "Apolipoprotein L1 (APOL1)-associated focal segmental glomerulosclerosis (FSGS) is the dominant form of FSGS in Black individuals. " 01/01/2022 - "A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis." 01/01/2021 - "The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). " 11/01/2019 - "Apolipoprotein L1 (APOL1) risk variants are strongly associated with sporadic focal segmental glomerulosclerosis (FSGS) in populations with African ancestry. " 01/01/2019 - "Apolipoprotein L1 (APOL1) risk variants are strongly associated with sporadic focal segmental glomerulosclerosis in populations with African ancestry. "
5.	AIDS-Associated Nephropathy (HIV-Associated Nephropathy) 01/01/2023 - "In Black populations, the G1 and G2 variants of the apolipoprotein L1 (APOL1) gene predispose to HIV-associated nephropathy (HIVAN). " 08/01/2012 - "HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics." 07/01/2021 - "Recent case reports suggest that coronavirus disease 2019 (COVID-19) is associated with collapsing glomerulopathy in African Americans with apolipoprotein L1 gene (APOL1) risk alleles; however, it is unclear whether disease pathogenesis is similar to HIV-associated nephropathy. " 01/01/2021 - "Variants in the Apolipoprotein L1 (APOL1) gene (G1-rs60910145, rs73885319, G2-rs71785313) are common in Africans and in individuals of recent African ancestry and are associated with an increased risk of non-diabetic chronic kidney disease (CKD) and in particular of HIV associated nephropathy (HIVAN). " 01/01/2015 - "Apolipoprotein L1 (APOL1) Variants (Vs) a possible link between Heroin-associated Nephropathy (HAN) and HIV-associated Nephropathy (HIVAN)."

Related Drugs and Biologics

1.	HDL Lipoproteins
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	DNA (Deoxyribonucleic Acid)
5.	Myosin Heavy Chains (Myosin Heavy Chain)
6.	Apolipoproteins
7.	Apolipoprotein L1
8.	Haptoglobins
9.	Albumins
10.	Prealbumin (Transthyretin)

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Transplantation
3.	Therapeutics
4.	Nephrectomy
5.	Genomic Medicine