KRIT1 Protein

A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.

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Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abdelilah-Seyfried, Salim: 1 article (10/2019)
2.	Donat, Stefan: 1 article (10/2019)
3.	Fischer, Dorothea: 1 article (10/2019)
4.	Freund, Christian: 1 article (10/2019)
5.	Kuropka, Benno: 1 article (10/2019)
6.	Lourenço, Marta: 1 article (10/2019)
7.	Otten, Cécile: 1 article (10/2019)
8.	Paolini, Alessio: 1 article (10/2019)
9.	Rödel, Claudia Jasmin: 1 article (10/2019)
10.	Aquila, Giorgio: 1 article (10/2019)

Related Diseases

1.	Central Nervous System Cavernous Hemangioma 01/01/2023 - "The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells. " 10/25/2019 - "Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. " 10/05/2019 - "Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human population. " 08/01/2010 - "Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernous malformations 1 protein (CCM1), CCM2, and CCM3. "
2.	Vascular Diseases (Vascular Disease) 08/01/2010 - "Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernous malformations 1 protein (CCM1), CCM2, and CCM3. "
3.	Neoplasms (Cancer) 02/27/2001 - "The mutations predicted truncation of the Krit1 mRNA encoded by CCM1, supporting the contention that CCM result from loss of Krit1 protein function and the possibility that this protein acts as a tumor suppressor."
4.	Cerebrovascular Disorders (Cerebrovascular Occlusion) 10/05/2019 - "Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human population. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)