Angiopoietin-Like Protein 4

A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

Also Known As:

Networked: 125 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kersten, Sander: 5 articles (01/2017 - 02/2013)
2.	Gao, Xia: 3 articles (10/2022 - 01/2020)
3.	Xu, Aimin: 3 articles (08/2014 - 04/2005)
4.	Rensen, Patrick C N: 3 articles (01/2014 - 02/2013)
5.	Smit, Johannes W A: 3 articles (01/2014 - 02/2013)
6.	Trayhurn, Paul: 3 articles (01/2011 - 12/2007)
7.	Gong, Wangqiu: 2 articles (10/2022 - 01/2022)
8.	Li, Yue: 2 articles (10/2022 - 01/2022)
9.	Aung, Tin May: 2 articles (07/2022 - 01/2022)
10.	Jusakul, Apinya: 2 articles (07/2022 - 01/2022)

Related Diseases

1.	Weight Gain 02/03/2012 - "Moreover, augmented 11βHSD1(-/-) adipose tissue angiogenesis is associated with enhanced peroxisome proliferator-activated receptor γ (PPARγ)-inducible expression of the potent angiogenic factors VEGF-A, apelin, and angiopoietin-like protein 4. Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain."
2.	Pancreatitis 11/01/2023 - "New targets directed towards inhibition of apolipoprotein C-III (apoC-III), angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like protein 4 (ANGPTL4), and fibroblast growth factor-21 (FGF21) offer far more efficacy in treating the various phenotypes of sHTG and opportunities to reduce the risk of acute pancreatitis and atherosclerotic cardiovascular disease events."
3.	Fibrosis (Cirrhosis) 02/03/2012 - "Moreover, augmented 11βHSD1(-/-) adipose tissue angiogenesis is associated with enhanced peroxisome proliferator-activated receptor γ (PPARγ)-inducible expression of the potent angiogenic factors VEGF-A, apelin, and angiopoietin-like protein 4. Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain."
4.	Cardiovascular Diseases (Cardiovascular Disease) 11/01/2023 - "New targets directed towards inhibition of apolipoprotein C-III (apoC-III), angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like protein 4 (ANGPTL4), and fibroblast growth factor-21 (FGF21) offer far more efficacy in treating the various phenotypes of sHTG and opportunities to reduce the risk of acute pancreatitis and atherosclerotic cardiovascular disease events."
5.	Hypoxia (Hypoxemia) 03/01/2022 - "Angiopoietin-like protein 4 (ANGPTL4) alleviates apoptosis and oxidative stress of BMSCs induced by serum deprivation and hypoxia; ANGPTL4 activates paracrine and accelerate metabolic energy of BMSCs; and ANGPTL4 treated-BMSCs alleviate myocardial injury of rats with MI. " 09/01/2015 - "Expression of angiopoietin-like protein 4 at the fracture site: Regulation by hypoxia and osteoblastic differentiation." 10/01/2012 - "Angiopoietin-like protein 4 (ANGPTL4) is expressed by endothelial cells and other tissues in response to hypoxia. " 11/01/2021 - "Angiopoietin-like protein 4 (ANGPTL4) is a hypoxia-induced gene, and its high expression is associated with poor prognosis and promotion of tumour progression in several cancers. " 02/01/2016 - "A member of the angiopoietin family, angiopoietin-like protein 4 (ANGPTL4) is a hypoxia-inducible gene. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Apolipoprotein C-III
3.	Peroxisome Proliferator-Activated Receptors (PPAR)
4.	fibroblast growth factor 21
5.	Glucocorticoids
6.	Angiopoietin-Like Protein 3
7.	Apelin
8.	Lipids
9.	Leptin
10.	Adipokines

Related Therapies and Procedures

1.	Therapeutics
2.	Bariatric Surgery
3.	Ligation