Angiopoietin-like Proteins

A family of proteins that is structurally similar to ANGIOPOIETINS but do not bind angiopoietin receptors. They are characterized by an amino-terminal coiled-coil domain, a linker region, and a carboxy-terminal FIBRINOGEN-like domain with the exception of ANGPTL8, which lacks the fibrinogen-like domain. They function in a variety of developmental and physiological processes, including INFLAMMATION, lipid metabolism, hematopoietic stem cell activity, and cancer metastasis.

Also Known As:

Networked: 82 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Oike, Yuichi: 11 articles (01/2022 - 10/2005)
2.	Kadomatsu, Tsuyoshi: 6 articles (04/2019 - 02/2011)
3.	Endo, Motoyoshi: 4 articles (01/2022 - 04/2012)
4.	Abu-Farha, Mohamed: 4 articles (01/2020 - 01/2018)
5.	Morinaga, Jun: 3 articles (01/2022 - 01/2016)
6.	Miyata, Keishi: 3 articles (01/2018 - 04/2012)
7.	Krintus, Magdalena: 2 articles (06/2022 - 11/2021)
8.	Kuligowska-Prusinska, Magdalena: 2 articles (06/2022 - 11/2021)
9.	Murawska, Karolina: 2 articles (06/2022 - 11/2021)
10.	Stefanska, Anna: 2 articles (06/2022 - 11/2021)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. " 01/01/2022 - "Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets." 02/01/2018 - "Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer." 06/01/2021 - "Angiopoietin-like proteins (ANGPTLs) are circulating proteins that are expressed in various cells and tissues and are thought to be involved in the repair and remodeling of damaged tissues; however, ANGPTL2 hyperfunction has been shown to cause chronic inflammation, leading to the progression of various diseases. " 04/28/2021 - "Although angiopoietin family Angiopoietin like proteins (Angptls), including Angptl1, have been reported to be involved in inflammation, lipid metabolism and angiogenesis, the roles of Angptl1 in bone have not been reported so far. "
2.	Dyslipidemias (Dyslipidemia) 06/11/2022 - "We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status." 11/30/2021 - "We suggest sex differences be taken into consideration when applying new therapies with angiopoietin-like proteins inhibitors in the treatment of dyslipidemia." 01/01/2023 - "Angiopoietin-like proteins inhibitors: New horizons in the treatment of atherogenic dyslipidemia and familial hypercholesterolemia." 10/01/2019 - "Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. " 01/01/2019 - "The angiopoietin-like proteins (ANGPTLs), consisting of ANGPTL3, ANGPTL4, and ANGPTL8, have gained significant interest for their role as inhibitors of lipoprotein lipase (LPL) and for their potential as therapeutic targets for correcting dyslipidemia. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 06/07/2023 - "Angiopoietin-Like Proteins: Cardiovascular Biology and Therapeutic Targeting for the Prevention of Cardiovascular Diseases." 01/01/2019 - "New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk." 01/01/2018 - "Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). " 12/01/2009 - "Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome and cardiovascular disease." 01/01/2020 - "Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders."
4.	Atherosclerosis 05/01/2020 - "The present study explored Angiopoietin-like protein (Angptl7) as a potential target in the process of atherosclerosis, and its role in the adhesion and oxidative stress induced by TNF-α in human umbilical vein epithelial cells (HUVEC). " 10/01/2021 - "Angiopoietin-like proteins in atherosclerosis." 07/06/2021 - "Apolipoproteins (Apo) and angiopoietin-like proteins (ANGPTLs) play a crucial role in regulating LPL activity and recent insights into LPL regulation may elucidate new pharmacological means to address the challenge of hypertriglyceridemia in atherosclerosis development." 02/28/2022 - "This review examines the role of endothelial progenitor cells in atherosclerosis development, and the impact standard antilipemic drugs, including statins, fibrates, and ezetimibe, as well as more novel treatments such as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulating agents and angiopoietin-like proteins (Angtpl3) inhibitors have on EPC biology."
5.	Non-alcoholic Fatty Liver Disease 01/01/2020 - "Angiopoietin-like proteins (ANGPTLs) are targets for vitamin D receptor (VDR)-mediated gene transcription and this axis may promote NAFLD. " 06/01/2018 - "The aim of the current study was to examine the difference between patients detected with nonalcoholic fatty liver disease (NAFLD) and healthy subjects in terms of serum angiopoietin-like protein (ANGPTL) 2 and ANGPTL6 levels and to evaluate the correlation between ANGPTL2 and ANGPTL6 levels and liver enzyme levels, fasting glucose, lipid levels, and steatosis degree on ultrasonography (USG). " 01/01/2021 - "While much work must be done to elucidate the mechanisms and interactions underlying alterations to hepatokines and adipokines, current data support the possible utility of these factors - in particular, angiopoietin-like proteins, fibroblast growth factors, and apelin - for detection or even as therapeutic targets in NAFLD-related HCC."

Related Drugs and Biologics

1.	Lipids
2.	Cholesterol Ester Transfer Proteins
3.	Apolipoprotein C-III
4.	Proteins (Proteins, Gene)
5.	Angiopoietins
6.	Glucose (Dextrose)
7.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
8.	Subtilisin
9.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
10.	Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1.	Therapeutics
2.	Bariatric Surgery
3.	Counterpulsation (External Counterpulsation)
4.	Exercise Therapy (Therapy, Exercise)