Zinc Finger Protein Gli2

A transcriptional activator that contains five adjacent CYS2-HIS2 ZINC FINGERS. It functions in the hedgehog signaling pathway and is required for normal embryonic development. Mutations in the GLI2 gene are associated with type 9 HOLOPROSENCEPHALY and type 2 PALLISTER-HALL SYNDROME.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cho, Se-Young: 1 article (05/2019)
2.	Kim, Duwoon: 1 article (05/2019)
3.	Kim, Yeong O: 1 article (05/2019)
4.	Kwon, Joseph: 1 article (05/2019)
5.	Oh, Myung-Joo: 1 article (05/2019)
6.	Protzman, Rachael A: 1 article (05/2019)
7.	Vaidya, Bipin: 1 article (05/2019)
8.	Dai, Yongdong: 1 article (01/2018)
9.	He, Shilin: 1 article (01/2018)
10.	Lin, Xiaona: 1 article (01/2018)

Related Diseases

1.	Fibrosis (Cirrhosis) 08/03/2015 - "Pharmacologic targeting of this pathway with darinaparsin, an arsenical in clinical trials, reduced fibrosis through reduction of GLI2 protein levels and subsequent cell-cycle arrest in myofibroblasts. " 01/01/2018 - "Menstrual-derived stem cell conditioned medium (MenSCs-CM) reduced endometrial fibrosis by reducing Gli2 protein levels and causing cell-cycle arrest in ESCs through granulocyte-colony stimulating factor (G-CSF). "
2.	Infections 05/01/2019 - "Overall, this study discovered a new mechanism for VHSV infection in vitro and in vivo that is regulated by GLI2 protein."
3.	Neoplasms (Cancer) 10/01/2010 - "Statistically, increased nuclear immunopositivity of Gli2 protein correlated significantly with poorer tumor differentiation (P<0.05), as well as with portal vein tumor thrombosis (P<0.05). " 10/01/2010 - "This is consistent with the concept that in human HCC, the Hh signaling pathway is involved in the differentiation and proliferation of tumor cells, in part through inducing nuclear accumulation of Gli2 protein and subsequent upregulation of FoxM1 protein." 07/14/2006 - "We also found that GLI2 protein is expressed highly in prostate cancer cell lines and primary tumors, whereas the level of GLI2 mRNA is not appreciably different in normal and neoplastic prostate. " 01/21/2010 - "Cyclopamine administration attenuated Hh signaling in the stroma rather than in the cancer cells as reflected by decreased expression of full length Gli2 protein and Gli1 mRNA specifically in the compartment. "
4.	Thrombosis (Thrombus) 10/01/2010 - "Statistically, increased nuclear immunopositivity of Gli2 protein correlated significantly with poorer tumor differentiation (P<0.05), as well as with portal vein tumor thrombosis (P<0.05). "
5.	Prostatic Neoplasms (Prostate Cancer) 07/14/2006 - "These data identify beta-TrCP2 as a pivotal regulator of Gli2 expression and point to an important role for posttranslational modulation of GLI2 protein levels in Hh pathway-associated human prostate cancer." 07/14/2006 - "We also found that GLI2 protein is expressed highly in prostate cancer cell lines and primary tumors, whereas the level of GLI2 mRNA is not appreciably different in normal and neoplastic prostate. "

Related Drugs and Biologics

1.	darinaparsin
2.	Messenger RNA (mRNA)
3.	Conditioned Culture Media
4.	Granulocyte Colony-Stimulating Factor (G-CSF)
5.	Ligands
6.	Forkhead Box Protein M1
7.	cyclopamine