rab27 GTP-Binding Proteins

GTP-binding proteins associated with membranes, MELANOSOMES; LYSOSOMES; and late ENDOSOMES. They play a role in the release of cytotoxic SECRETORY GRANULES from lymphocytes and are required for granule maturation, as well as granule docking and priming at IMMUNOLOGICAL SYNAPSES.

Also Known As:

GTP-binding Protein Ram; Rab27 Protein; Rab27a Protein; GTP binding Protein Ram; GTP-Binding Proteins, rab27; Ram, GTP-binding Protein; rab27 GTP Binding Proteins

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhu, Huijun: 2 articles (06/2015 - 01/2015)
2.	Gong, Xue: 1 article (09/2017)
3.	Liu, Jia: 1 article (09/2017)
4.	Liu, Yili: 1 article (09/2017)
5.	Wang, Ping: 1 article (09/2017)
6.	Xue, Dongwei: 1 article (09/2017)
7.	Zhu, Xingwang: 1 article (09/2017)
8.	Chen, Pingsheng: 1 article (06/2015)
9.	Hou, Ning: 1 article (06/2015)
10.	Ni, Yijiang: 1 article (06/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/13/2015 - "Cox multi-factor analysis and Kaplan-Meier method suggested Rab27A protein expression (p = 0.012) and tumor differentiation (p = 0.004) were significantly associated with the overall survival of CRC patients. " 01/01/2015 - "High RAB27A protein expression (RAB27A+) was significantly associated with tumor stage and vascular invasion. "
2.	Triple Negative Breast Neoplasms 04/20/2023 - "To investigate the effect of inhibition of RAB27 protein family, which plays a pivotal role in exosome secretion, on biological behaviors of triple-negative breast cancer cells. "
3.	Hermanski-Pudlak Syndrome (Hermansky-Pudlak Syndrome) 07/01/2002 - "The ashen (ash) mouse, a model for Hermansky-Pudlak syndrome (HPS) and for a subset of patients with Griscelli syndrome, presents with hypopigmentation, prolonged bleeding times, and platelet storage pool deficiency due to a mutation which abrogates expression of the Rab27a protein. "
4.	Hypopigmentation (Hypomelanosis) 07/01/2002 - "The ashen (ash) mouse, a model for Hermansky-Pudlak syndrome (HPS) and for a subset of patients with Griscelli syndrome, presents with hypopigmentation, prolonged bleeding times, and platelet storage pool deficiency due to a mutation which abrogates expression of the Rab27a protein. "
5.	Platelet Storage Pool Deficiency 07/01/2002 - "The ashen (ash) mouse, a model for Hermansky-Pudlak syndrome (HPS) and for a subset of patients with Griscelli syndrome, presents with hypopigmentation, prolonged bleeding times, and platelet storage pool deficiency due to a mutation which abrogates expression of the Rab27a protein. "

Related Drugs and Biologics

1.	GTP Phosphohydrolases (GTPases)
2.	Protein Isoforms (Isoforms)
3.	Proteins (Proteins, Gene)