Promyelocytic Leukemia Zinc Finger Protein

A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

Also Known As:

PLZF Protein; Promyelocytic Leukaemia Zinc Finger Protein; ZBTB16 Protein; Zinc Finger and BTB Domain Containing 16 Protein

Networked: 55 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Kruppel-Like Transcription Factors: 252
      - Promyelocytic Leukemia Zinc Finger Protein: 55
        human ZBTB16 protein
        mouse Zbtb16 protein
        rat ZBTB16 protein
        zebrafish zbtb16a protein
        zebrafish zbtb16b protein
  - DNA-Binding Proteins: 2009
    - Kruppel-Like Transcription Factors: 252
      - Promyelocytic Leukemia Zinc Finger Protein: 55
        human ZBTB16 protein
        mouse Zbtb16 protein
        rat ZBTB16 protein
        zebrafish zbtb16a protein
        zebrafish zbtb16b protein

Experts

1.	Higashiyama, Shigeki: 4 articles (01/2013 - 07/2006)
2.	Licht, Jonathan D: 3 articles (06/2009 - 02/2004)
3.	Amirjannati, Naser: 2 articles (04/2021 - 01/2019)
4.	Mazaheri, Zohreh: 2 articles (04/2021 - 01/2019)
5.	Mohaqiq, Mahdi: 2 articles (04/2021 - 01/2019)
6.	Movahedin, Mansoureh: 2 articles (04/2021 - 01/2019)
7.	Liu, Chang: 2 articles (12/2014 - 01/2013)
8.	Xu, Dakang: 2 articles (01/2012 - 06/2009)
9.	McConnell, Melanie J: 2 articles (06/2009 - 06/2004)
10.	Nanba, Daisuke: 2 articles (04/2007 - 07/2006)

Related Diseases

1.	Leukemia 01/01/2019 - "In this experimental study, human SSCs were isolated and their identities were confirmed by tracking their promyelocytic leukemia zinc finger (PLZF) protein. " 04/01/2021 - "Human SSCs were obtained from a Testicular Sperm Extractions (TESE) sample, and characterization of these cells was confirmed by detecting the promyelocytic leukemia zinc finger (PLZF) protein. " 02/01/2021 - "Based on the bimolecular fluorescence complementation (BiFC) and co-immunoprecipitation (co-IP) assay, it was finally revealed that the interaction between DMRT1 and promyelocytic leukemia zinc finger (PLZF) protein was essential for maintaining self-renewal of mGSCs. " 11/01/2015 - "Expression of promyelocytic leukemia zinc finger (PLZF) protein directs the effector differentiation of invariant NKT (iNKT) cells and IL-4(+) γδ NKT cells. " 06/30/2015 - "The promyelocytic leukemia zinc finger (Plzf) protein plays an essential role in spermatogonia maintenance by preventing their differentiation. "
2.	Overweight 01/01/2020 - "Blood samples from 41 normal weight and 41 overweight children of the Lifestyle Immune System Allergy (LISA) study were analyzed with respect to MAIT cell surface and activation markers [CD107a, CD137, CD69, interferon (IFN)-γ, tumor necrosis factor (TNF)-α] after Escherichia coli stimulation, mRNA expression of promyelocytic leukemia zinc finger protein (PLZF) and major histocompatibility complex class I-related gene protein (MR1), the inflammatory markers C-reactive protein (CRP), interleukin (IL)-8 and macrophage inflammatory protein (MIP)-1α as well as the concentrations of 13 conjugated and unconjugated BAs. "
3.	Leiomyosarcoma 09/01/2014 - "This study is the first to evaluate the utility of the promyelocytic leukemia zinc finger (PLZF) protein and the histone 1.5 (H1.5) protein as potential diagnostic immunohistochemical markers for distinguishing leiomyosarcoma from leiomyoma. "
4.	Leiomyoma (Uterine Fibroids) 09/01/2014 - "This study is the first to evaluate the utility of the promyelocytic leukemia zinc finger (PLZF) protein and the histone 1.5 (H1.5) protein as potential diagnostic immunohistochemical markers for distinguishing leiomyosarcoma from leiomyoma. "
5.	Hypersensitivity (Allergy) 01/01/2020 - "Blood samples from 41 normal weight and 41 overweight children of the Lifestyle Immune System Allergy (LISA) study were analyzed with respect to MAIT cell surface and activation markers [CD107a, CD137, CD69, interferon (IFN)-γ, tumor necrosis factor (TNF)-α] after Escherichia coli stimulation, mRNA expression of promyelocytic leukemia zinc finger protein (PLZF) and major histocompatibility complex class I-related gene protein (MR1), the inflammatory markers C-reactive protein (CRP), interleukin (IL)-8 and macrophage inflammatory protein (MIP)-1α as well as the concentrations of 13 conjugated and unconjugated BAs. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Interferons
3.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Messenger RNA (mRNA)
6.	Interleukins
7.	Histones (Histone)
8.	Glucose (Dextrose)
9.	C-Reactive Protein
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration