T-Lymphoma Invasion and Metastasis-inducing Protein 1

A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.

Also Known As:

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lin, Zhenhua: 3 articles (01/2018 - 01/2016)
2.	Yang, Yang: 2 articles (01/2018 - 11/2016)
3.	Piao, Junjie: 2 articles (11/2016 - 01/2016)
4.	Wang, Jing: 2 articles (01/2016 - 01/2012)
5.	Bandapalli, Obul Reddy: 1 article (01/2021)
6.	Bonora, Elena: 1 article (01/2021)
7.	Diquigiovanni, Chiara: 1 article (01/2021)
8.	Försti, Asta: 1 article (01/2021)
9.	Giangiobbe, Sara: 1 article (01/2021)
10.	Hemminki, Kari: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "Recent studies have shown that high expression levels of Tiam1 protein appear to be associated with the progression of numerous human tumors. " 01/01/2016 - "T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence and progression. " 01/01/2012 - "Tiam1 protein expression in the lung tumor tissue is significantly higher than that in the normal lung tissue and fetal lung tissue. " 01/01/2016 - "This study attempted to explore the role of Tiam1 protein in tumor progression and the prognostic evaluation of breast cancer. " 11/01/2016 - "Strongly-positive Tiam1 protein expression was observed in 59.3% (108/182) of ovarian carcinomas, which was significantly higher than in benign serous tumors (12.5%; 9/72). "
2.	Stomach Neoplasms (Stomach Cancer) 08/01/2013 - "In a previous study, the overexpression of Tiam-1 protein was identified by immunohistochemistry in human gastric cancer tissues, indicating that Tiam-1 may represent a candidate biomarker of the invasive and metastatic capacity of gastric cancer and for patient prognosis. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "Tiam1 protein showed a mainly cytoplasmic staining pattern in breast cancer cells; however, nuclear staining was also observed. " 01/01/2016 - "The localization of the Tiam1 protein was determined in the MDA-MB-231 breast cancer cell line using immunofluorescence (IF) staining. " 01/01/2016 - "This study attempted to explore the role of Tiam1 protein in tumor progression and the prognostic evaluation of breast cancer. " 01/01/2016 - "In addition, a total of 283 breast tissue samples, including 153 breast cancer tissues, 67 ductal carcinoma in situ (DCIS) and 63 adjacent non-tumor breast tissues, were analyzed by immunohistochemical (IHC) staining of the Tiam1 protein. "
4.	Neoplasm Metastasis (Metastasis) 11/01/2016 - "High Tiam1 protein expression was closely associated with a high histological grade, metastasis, advanced clinical stage and lower OS rates in ovarian carcinoma. " 07/01/2012 - "We have now identified an additional and direct mechanism for CtBP stimulation of cell migration via regulation of T-cell lymphoma invasion and metastasis 1 (Tiam1) protein. " 01/01/2018 - "High Tiam1 protein expression was closely associated with advanced clinical stage, differentiation, lymph node (LN) metastasis, HPV infection and lower overall survival (OS) rates in cervical cancer. " 09/14/2015 - "Overexpression of the T lymphoma invasion and metastasis 1 (Tiam1) protein has been implicated in the migration and invasion of neoplasms. " 01/01/2015 - "Tiam1 protein expression in cholangiocarcinoma tissues had correlations with cholangiocarcinoma differentiation degree, TNM stage and lymph node metastasis (P<0.05), and had no significant correlations with gender, age and distant metastasis (P>0.05). "
5.	Lymphoma (Lymphomas) 05/20/1994 - "In the selected invasive T lymphoma variants, proviral insertions were found within coding exons of the Tiam-1 gene, resulting in both truncated 5'-end and 3'-end transcripts that give rise to N- and C-terminal Tiam-1 protein fragments. " 09/14/2015 - "Overexpression of the T lymphoma invasion and metastasis 1 (Tiam1) protein has been implicated in the migration and invasion of neoplasms. " 12/07/2000 - "Here we have determined the crystal structure of the DH and PH domains of the T-lymphoma invasion and metastasis factor 1 (Tiam1) protein in complex with its cognate Rho family G protein, Rac1. " 04/01/2001 - "The invasion-inducing T-lymphoma and metastasis 1 (Tiam1) protein that functions as a guanosine nucleotide exchange factor for Rac1 localizes to this neurite and its growth cone, where it associates with microtubules. " 11/03/1997 - "The invasion-inducing T-lymphoma invasion and metastasis 1 (Tiam1) protein functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	GTP-Binding Proteins (G-Protein)
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Checkpoint Kinase 2
6.	Osteopontin
7.	Small Interfering RNA (siRNA)
8.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
9.	Monomeric GTP-Binding Proteins
10.	Peptides (Polypeptides)