DCC Receptor
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
Also Known As:
DCC Tumor Suppressor Protein; DCC-Netrin-1 Receptor; Deleted in Colorectal Carcinoma Protein; DCC Netrin 1 Receptor; Receptor, DCC; Receptor, DCC-Netrin-1
Networked: 64
relevant articles (1 outcomes,
2 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Flores, Cecilia:
7 articles
(01/2020 - 06/2011)
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2. | Mehlen, Patrick:
6 articles
(01/2021 - 08/2004)
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3. | Cooper, Helen M:
4 articles
(01/2018 - 06/2011)
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4. | Meijers, Rob:
3 articles
(01/2020 - 08/2014)
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5. | Wang, Jia-Huai:
3 articles
(01/2020 - 08/2014)
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6. | Zhang, Yan:
3 articles
(01/2020 - 08/2014)
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7. | Eng, Conrad:
3 articles
(01/2018 - 06/2011)
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8. | Manitt, Colleen:
3 articles
(01/2018 - 06/2011)
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9. | Lamarche-Vane, Nathalie:
3 articles
(02/2009 - 04/2002)
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10. | Kania, Artur:
2 articles
(01/2022 - 01/2018)
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