S100 Calcium Binding Protein A6

An S100 calcium binding protein that contains two EF HAND MOTIFS and plays a role as a calcium sensor and modulator for many cellular processes such as CELL CYCLE progression; CELL MOTILITY and reorganization of the ACTIN CYTOSKELETON. Its expression is induced by growth factors and it is overexpressed in patients with ACUTE MYELOID LEUKEMIA.

Also Known As:

Networked: 131 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Filipek, Anna: 6 articles (05/2014 - 06/2002)
2.	Fan, Daiming: 6 articles (10/2011 - 09/2002)
3.	Ning, Xiaoxuan: 5 articles (01/2018 - 05/2007)
4.	Sun, Shiren: 4 articles (08/2016 - 05/2007)
5.	Liang, Jie: 4 articles (01/2012 - 12/2006)
6.	Güzel, Coşkun: 3 articles (01/2019 - 03/2007)
7.	Luider, Theo M: 3 articles (01/2019 - 03/2007)
8.	Steegers, Eric A P: 3 articles (01/2019 - 03/2007)
9.	Zhai, Huihong: 3 articles (01/2018 - 01/2008)
10.	George, Jasmine: 3 articles (01/2013 - 03/2010)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2021 - "We investigated that Calcyclin (S100A6) relieved the inflammation and mediated the chondrocyte apoptosis through PI3K/AKT pathway and we confirmed that S100A6 might be an attractive therapeutic target." 01/14/2008 - "We identified 27 different formaldehyde-inducible genes, including those coding for the major histocompatibility complex, class IA, calcyclin, glutathione S-transferase pi, mouse double minute 2 (MDM2), platelet-derived growth factor receptor alpha, and which are known to be associated with cell proliferation and differentiation, immunity and inflammation, and detoxification. "
2.	Vascular Remodeling 08/30/2022 - "Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension."
3.	Pulmonary Arterial Hypertension 08/30/2022 - "Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension."
4.	Stomach Neoplasms (Stomach Cancer) 09/20/2011 - "In conclusion, calcyclin can promote the growth and proliferation of gastric cancer cells and knockdown of calcyclin can restrain the growth and proliferation of gastric cancer cells. " 09/20/2011 - "The role of calcyclin gene in the proliferation and migration of gastric cancer cells." 09/20/2011 - "The aim of this study was to investigate the influence of calcyclin on the growth, proliferation, apoptosis, invasion and cell cycle of gastric cancer cell lines in order to elucidate the role that calcyclin plays in gastric adenocarcinoma. " 01/01/2012 - "S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis." 12/12/2006 - "To study the effect of calcyclin binding protein (CacyBP) on the proliferation of gastric cancer cells. "
5.	Neoplasms (Cancer) 11/01/2008 - "The goal of this study was to determine the specificity and sensitivity of S100A6 protein in a spectrum of cutaneous mesenchymal or epithelial tumors. " 08/01/2023 - "S100 calcium-binding protein A6 (S100A6) is upregulated in many malignancies. " 09/01/2018 - "S100 calcium-binding protein A6 (S100A6) is up-regulated in many malignancies and overexpression of S100A6 has been identified associated with proliferation, migration and invasion phenotype in several cancer cells. " 11/01/2008 - "Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays." 01/01/2008 - "Insufficient suppression of this gene by p53 mutants could well be responsible for calcyclin overexpression and cell cycle deregulation observed in cancer tissues."

Related Drugs and Biologics

1.	Carrier Proteins (Binding Protein)
2.	Proteins (Proteins, Gene)
3.	Annexin A2 (Annexin II)
4.	RNA (Ribonucleic Acid)
5.	Vimentin
6.	Heat-Shock Proteins (Heat-Shock Protein)
7.	Secretagogins
8.	Small Cytoplasmic RNA
9.	Superoxide Dismutase
10.	Phosphates (Orthophosphate)