Anoctamins

A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.

Also Known As:

Networked: 87 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kunzelmann, Karl: 9 articles (01/2022 - 08/2011)
2.	Schreiber, Rainer: 9 articles (01/2022 - 08/2011)
3.	Ousingsawat, Jiraporn: 5 articles (03/2019 - 08/2011)
4.	Mahjneh, Ibrahim: 4 articles (01/2019 - 02/2010)
5.	Sirianant, Lalida: 4 articles (01/2018 - 03/2014)
6.	Wanitchakool, Podchanart: 4 articles (01/2018 - 03/2014)
7.	Han, Renzhi: 3 articles (12/2021 - 01/2014)
8.	Xu, Li: 3 articles (12/2021 - 01/2014)
9.	Vissing, John: 3 articles (12/2021 - 08/2013)
10.	Chandra, Goutam: 3 articles (04/2021 - 01/2019)

Related Diseases

1.	Distal Myopathies (Distal Muscular Dystrophy) 10/01/2012 - "Selective pattern of muscle involvement seen in distal muscular dystrophy associated with anoctamin 5 mutations: a follow-up muscle MRI study." 10/10/2012 - "Therefore, given the increasing number of anoctamin 5 mutations in Miyoshi-like phenotypes, genetic analysis should include an anoctamin 5 screen in late-onset limb-girdle and distal myopathies." 10/10/2012 - "Mutations in the anoctamin 5 gene have so far been identified only in some cases of limb-girdle and distal myopathy. " 10/01/2012 - "We conclude that the pattern of muscle involvement seen in patients with distal myopathy with anoctamin 5 mutations (MMD3) is typical and can thus be useful during the differential diagnosis process allowing for a more targeted molecular approach." 02/01/2012 - "Miyoshi-like distal myopathy with mutations in anoctamin 5 gene."
2.	Chronic Obstructive Pulmonary Disease (COPD) 03/17/2015 - "These results suggest cooperative roles for CLCA and TMEM16 proteins in influencing the physiology of multiple tissues, and the pathology of multiple diseases, including asthma, COPD, cystic fibrosis, and certain cancers. " 05/05/2022 - "Our previous whole-exome sequencing study of three Uyghur families with COPD demonstrated that 72 mutations in 55 genes might be associated with COPD; these included rs15783G > A in the anoctamin 3 (ANO3) gene/mucin 15 (MUC15) gene, rs1800517G > A in the collagen type IV alpha 4 chain (COL4A4) gene, rs11960G > A in the ribosome binding protein 1 (RRBP1) gene, and rs5516C > G in the kallikrein 1 (KLK1) gene. "
3.	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 06/01/2018 - "Novel Mutation in Anoctamin 5 Gene Causing Limb-Girdle Muscular Dystrophy 2L." 02/01/2013 - "Novel mutations in the Anoctamin 5 gene (ANO5) associated with limb-girdle muscular dystrophy 2L." 11/01/2012 - "Limb-girdle muscular dystrophy (LGMD) 2L, caused by mutations in the anoctamin 5 (ANO5) gene, is the third most common LGMD in Northern and Central Europe, where the c.191dupA mutation causes the majority of cases. " 11/01/2012 - "Frequency and characterisation of anoctamin 5 mutations in a cohort of Italian limb-girdle muscular dystrophy patients." 01/01/2011 - "A founder mutation in Anoctamin 5 is a major cause of limb-girdle muscular dystrophy."
4.	Muscular Dystrophies (Muscular Dystrophy) 12/01/2021 - "Mutations in the anoctamin 5 (ANO5) gene are a common cause of muscular dystrophy. " 10/01/2020 - "Anoctamin 5 (ANO5) muscular dystrophy-three different phenotypes and a new histological pattern." 01/01/2014 - "Anoctamin 5 muscular dystrophy associated with a silent p.Leu115Leu mutation resulting in exon skipping." 08/01/2013 - "Since the initial description in 2010 of anoctamin 5 deficiency as a cause of muscular dystrophy, a handful of papers have described this disease in cases of mixed populations. " 12/01/2011 - "[Muscular dystrophy due to mutations in anoctamin 5: clinical and molecular genetic findings]."
5.	Neoplasms (Cancer) 01/20/2022 - "Ca2+-activated Cl- channels (TMEM16, also known as anoctamins) perform important functions in cell physiology, including modulation of cell proliferation and cancer growth. " 03/19/2014 - "Role of anoctamins in cancer and apoptosis." 01/01/2014 - "Ano6 deficiency significantly reduces ERK/AKT phosphorylation, which has been shown to be involved in regulation of cancer cell proliferation by another Anoctamin member. " 08/01/2011 - "Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. " 11/01/2005 - "Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer."

Related Drugs and Biologics

1.	Collagen Type IV (Type IV Collagen)
2.	Tissue Kallikreins (Tissue Kallikrein)
3.	Mucins
4.	Carrier Proteins (Binding Protein)
5.	Proteins (Proteins, Gene)
6.	Chloride Channels (Chloride Channel)
7.	Dysferlin
8.	Ion Channels (Ion Channel)
9.	Phospholipids (Phosphatides)
10.	Calcium

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)