Apelin Receptors

G-protein coupled receptors for APELIN that function in a broad range of physiologic processes including blood pressure regulation and heart contractility. They also have an essential role in early embryo development for GASTRULATION and heart morphogenesis, and can also function as a CD4 co-receptor for HIV-1.

Also Known As:

Networked: 169 relevant articles (9 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Davenport, Anthony P: 9 articles (11/2021 - 08/2010)
2.	Maguire, Janet J: 8 articles (11/2021 - 08/2010)
3.	Kuc, Rhoda E: 6 articles (11/2021 - 08/2010)
4.	Glen, Robert C: 6 articles (06/2020 - 06/2011)
5.	Nyimanu, Duuamene: 5 articles (11/2021 - 01/2019)
6.	Wang, Tao: 4 articles (10/2022 - 01/2021)
7.	Hellawell, Jennifer: 4 articles (06/2022 - 03/2022)
8.	Trivedi, Ashit: 4 articles (06/2022 - 03/2022)
9.	De Mota, Nadia: 4 articles (12/2021 - 11/2011)
10.	Girault-Sotias, Pierre-Emmanuel: 4 articles (12/2021 - 01/2021)

Related Diseases

1.	Hyponatremia 01/01/2021 - "Activation of the apelin receptor by the metabolically stable apelin-17 analog, that increases aqueous diuresis and moderately water intake and gradually corrects hyponatremia, may constitute a new approach for the treatment of SIAD. " 01/01/2021 - "[Physiological role of the apelin receptor: implication in body fluid homeostasis and hyponatremia]." 12/01/2021 - "We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may be beneficial for treating the Syndrome of Inappropriate Antidiuresis, in which AVP hypersecretion leads to hyponatremia. " 01/01/2021 - "In a rat experimental model of vasopressin-induced hyponatremia, subcutaneously (s.c.) administered LIT01-196 blocks the antidiuretic effect of vasopressin and the vasopressin-induced increase in urinary osmolality, and induces a progressive improvement in hyponatremia, suggesting that apelin receptor activation constitutes an original approach for hyponatremia treatment."
2.	Heart Failure 01/01/2023 - "A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients." 01/01/2023 - "Knockdown in 3D engineered heart tissues recapitulated the phenotype of apelin receptor down-regulation in a failing heart, providing a potential platform for modelling heart failure and testing novel therapeutic strategies." 10/01/2022 - "Agonism of the apelin receptor (APJ) has demonstrated beneficial effects in models of heart failure. " 06/01/2022 - "AMG 986 is a first-in-class, novel apelin receptor small molecule agonist initially developed for the treatment of heart failure. " 06/01/2022 - "AMG 986 is a first-in-class, novel apelin receptor small molecule agonist initially developed as a treatment for patients with heart failure (HF). "
3.	Breast Neoplasms (Breast Cancer) 05/15/2023 - "Apelin receptor antagonist boosts dendritic cell vaccine efficacy in controlling angiogenic, metastatic and apoptotic-related factors in 4T1 breast tumor-bearing mice." 09/30/2022 - "In the present study, we show that the breast cancer cell line MCF-7 expresses the APLNR as shown by immunofluorescence and flow cytometry, under conditions of ER starvation and that culture of these cells in the presence of apelin-13 results in an increased growth rate and a diminished autophagy flux. " 09/30/2022 - "They furthermore suggest an alternative mechanism of estrogen-independent tumor growth thereby positioning the APLNR-AMPK axis as a novel pathway and a possible therapeutic target in endocrine resistance of breast cancer cells." 03/01/2022 - "Here, we investigated the efficacy of a dendritic cell (DC) vaccine in combination with an apelin receptor antagonist, ML221, to modulate Th1 and Th2 cell-related responses in breast cancer-bearing mice. " 09/30/2022 - "Taken together, our results show that APLNR signaling in breast cancer cells is functional and prevents tumor growth under conditions of estrogen starvation. "
4.	Melanoma (Melanoma, Malignant) 11/01/2022 - "Taken together, our findings reveal that APLNR modulates IFN-γ signaling in melanoma cells and suggest that APLNR may be a potential target to enhance the efficacy of immunotherapy." 01/01/2023 - "Cancer apelin receptor suppresses vascular mimicry in malignant melanoma." 11/01/2022 - "APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells." 01/01/2022 - "We identified three genes (LGALS1, CPXM1, APLNR) that showed a high level of differential expression in melanoma. " 01/01/2022 - "The expression levels of LGALS1, CPXM1, and APLNR were higher in melanoma than in normal tissues and were associated with worse patient survival. "
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2013 - "Therefore, we observed apelin/APLNR expression in kidneys from patients with type 2 diabetes as well as the correlation between albuminuria and serum apelin in patients with type 2 diabetes. " 06/01/2010 - "However, the regulation of apelin and APJ (apelin receptor) expression in skeletal muscle in relation to insulin resistance or type 2 diabetes is not known. " 09/01/2010 - "Clinically, the development of non-peptide analogs of the apelin receptor could provide new therapeutic tools potentially useful for the treatment of heart failure, states of water and/or electrolyte retention, and type 2 diabetes mellitus."

Related Drugs and Biologics

1.	Apelin
2.	Peptides (Polypeptides)
3.	Vaccines
4.	Antidiuretic Agents
5.	Vasopressins (Vasopressin)
6.	Electrolytes
7.	4- oxo- 6- ((pyrimidin- 2- ylthio)methyl)- 4H- pyran- 3- yl 4-nitrobenzoate
8.	Apelin Receptors
9.	apelin-13 peptide
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Laparotomy
4.	Surgical Instruments (Clip)
5.	Lung Transplantation