Myeloid Ecotropic Viral Integration Site 1 Protein

A TALE-type homeodomain protein and transcription factor that functions as a regulator of PAX6 PROTEIN expression and as an activator of PLATELET FACTOR 4 gene expression. It is essential for hematopoiesis, differentiation of MEGAKARYOCYTES, and vascular patterning. It may also have a role in the induction of myeloid leukemias.

Also Known As:

Homeobox Protein MEIS1; Meis-1 Protein; Meis1 Protein; Meis1 Transcription Factor; MEIS1, Homeobox Protein; Meis 1 Protein; Transcription Factor, Meis1

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Myeloid Ecotropic Viral Integration Site 1 Protein: 14
  - DNA-Binding Proteins: 2009
    - Homeodomain Proteins: 350
      - Myeloid Ecotropic Viral Integration Site 1 Protein: 14
        human MEIS1 protein
        mouse Meis1 protein
        Xenopus Meis1b protein
        zebrafish meis1b protein

Experts

1.	Forghanifard, Mohammad Mahdi: 2 articles (05/2020 - 02/2016)
2.	Cui, Liang: 2 articles (01/2017 - 10/2014)
3.	Gao, Jiangping: 2 articles (01/2017 - 10/2014)
4.	Copeland, Neal G: 2 articles (02/2016 - 12/2012)
5.	Jenkins, Nancy A: 2 articles (02/2016 - 12/2012)
6.	Kocabaş, Fatih: 1 article (01/2022)
7.	Meriç, Neslihan: 1 article (01/2022)
8.	Chen, Zhanjuan: 1 article (09/2021)
9.	Gu, Yong: 1 article (09/2021)
10.	Yang, Zhaoxin: 1 article (09/2021)

Related Diseases

1.	Leukemia 01/01/2022 - "In addition, it was suggested that MEIS1 protein could be utilized as a possible treatment target in leukemia with an emphasis on the inhibition of MEIS1, which is overexpressed in LSC." 01/01/2022 - "In this review article, the molecular mechanism of the oncological role of the MEIS1 protein in leukemia and LSC is discussed. " 12/13/2012 - "The transcription factor Meis1 is expressed preferentially in hematopoietic stem cells (HSCs) and overexpressed in certain leukemias. " 02/01/2011 - "The Meis1 protein represents an important cofactor for Hox and Pbx1 and is implicated in human and murine leukemias. " 01/01/2018 - "The homeobox transcription factor Meis1 is required for mammalian development, and its overexpression plays a role in tumorigenesis, especially leukemia. "
2.	Neoplasms (Cancer) 02/01/2016 - "Also, MEIS1 protein levels inversely correlated to lymph node involvement (P = 0.048) and high tumor stage (stages III/IV, P = 0.030). " 05/01/2020 - "The homeobox transcription factor MEIS1 is involved in cell fate decision, stem cells properties, gastrointestinal (GI) tract development, and progression of several malignancies such as esophageal squamous cell carcinoma (ESCC). " 10/15/2014 - "MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. " 09/01/2021 - "As a transcription factor, MEIS1 protein is involved in cell proliferation in leukemia and some solid tumors. "
3.	Carcinogenesis 01/01/2018 - "The homeobox transcription factor Meis1 is required for mammalian development, and its overexpression plays a role in tumorigenesis, especially leukemia. "
4.	Cardiac Sudden Death (Sudden Cardiac Arrest) 02/08/2016 - "Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death."
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2017 - "Myeloid ecotropic viral integration site 1 (MEIS1) protein plays a synergistic causative role in acute myeloid leukemia (AML). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	CD146 Antigen
3.	Chemokines
4.	Transcription Factors (Transcription Factor)
5.	Messenger RNA (mRNA)