Pre-B-Cell Leukemia Transcription Factor 1

A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.

Also Known As:

Networked: 12 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aozasa, Katsuyuki: 2 articles (07/2009 - 01/2007)
2.	Morii, Eiichi: 2 articles (07/2009 - 01/2007)
3.	Qiu, Ying: 2 articles (07/2009 - 01/2007)
4.	Tomita, Yasuhiko: 2 articles (07/2009 - 01/2007)
5.	Zhang, Binglin: 2 articles (07/2009 - 01/2007)
6.	Che, Jizhong: 1 article (01/2022)
7.	Li, Shuhang: 1 article (01/2022)
8.	Liu, Songlin: 1 article (01/2022)
9.	Tian, Aimin: 1 article (01/2022)
10.	Wan, Yinxu: 1 article (01/2022)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 01/01/2016 - "Results indicated that pre-B-cell leukemia transcription factor 1 and cyclic AMP-dependent transcription factor 1, along with six other TFs, are putative target TFs for DHI-mediated protection against cerebral ischemia. "
2.	Neoplasms (Cancer) 01/01/2022 - "Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to be involved in tumor progression. " 01/01/2016 - "PBXl (pre-B-cell leukemia transcription factor 1) and LAMC2 (laminin subunit gamma-2) were cancer-promoting genes and also, PBX was TF. " 01/01/2007 - "Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth." 07/01/2009 - "Previous studies on the mammary carcinoma cell line have shown that the pre B cell leukemia transcription factor 1 (PBX1) was a transcription factor for valosin-containing protein (VCP), which is involved in invasion and metastasis of cancers. "
3.	Neoplasm Metastasis (Metastasis) 07/01/2009 - "Previous studies on the mammary carcinoma cell line have shown that the pre B cell leukemia transcription factor 1 (PBX1) was a transcription factor for valosin-containing protein (VCP), which is involved in invasion and metastasis of cancers. "
4.	Carcinoma (Carcinomatosis) 07/01/2009 - "Previous studies on the mammary carcinoma cell line have shown that the pre B cell leukemia transcription factor 1 (PBX1) was a transcription factor for valosin-containing protein (VCP), which is involved in invasion and metastasis of cancers. "
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2008 - "Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2 diabetes mellitus. " 11/01/2005 - "Evaluation of sequence variants in the pre-B cell leukemia transcription factor 1 gene: a positional and functional candidate for type 2 diabetes and impaired insulin secretion."

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Cyclic AMP (AMP, Cyclic)
3.	Valosin Containing Protein
4.	MEF2 Transcription Factors
5.	Cyclin A2
6.	Clusterin
7.	Apoptosis Regulatory Proteins
8.	Galectin 1 (LGALS1)
9.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
10.	Nuclear Proteins (Protein, Nuclear)