Forkhead Box Protein L2

A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).

Also Known As:

Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Huntsman, David G: 2 articles (01/2017 - 04/2011)
2.	Ge, Jun: 1 article (04/2020)
3.	Huang, Meiling: 1 article (04/2020)
4.	Jiang, Li: 1 article (04/2020)
5.	Li, Juan: 1 article (04/2020)
6.	Tian, Yuke: 1 article (04/2020)
7.	Zheng, Min: 1 article (04/2020)
8.	Anglesio, Michael S: 1 article (01/2017)
9.	Iida, Yasushi: 1 article (01/2017)
10.	Inoue, Momoko: 1 article (01/2017)

Related Diseases

1.	Blepharophimosis 02/09/2011 - "The purpose of this study was to identify the mutation(s) or deletion(s) of the forkhead box protein L2 (FOXL2) gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). " 11/01/2011 - "To analyse mutational points of FOXL2 gene in 5 Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and to predict structural changes of the mutational FOXL2 protein. " 08/01/2004 - "FOXL2 mutations, causing a truncation of the FOXL2 protein in the forkhead domain or in the poly-Ala tract lead to blepharophimosis-ptosis-epicanthus-inversus syndrome associated with POF (BPES I). " 03/01/2003 - "Mutations in the forkhead transcription factor gene 2 (FOXL2) were recently reported to cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II. Evidence was provided that BPES type I (eyelid abnormalities and female infertility) is caused by mutations resulting in a truncated FOXL2 protein. "
2.	Squamous Cell Carcinoma of Head and Neck 04/01/2020 - "This study aimed to explore the expression profile of the Forkhead box protein L2 gene (FOXL2) and to determine its prognostic value and associated epigenetic and genetic alterations in patients with laryngeal squamous cell carcinoma (LSCC). "
3.	Neoplasms (Cancer) 01/01/2017 - "The genetic analysis showed all the samples, including recurrent tumor samples up to 14 years after the primary surgery, expressed heterozygous c.402C>G FOXL2 mutation and the FOXL2 protein expression. " 04/01/2011 - "Using a commercially available polyclonal antiserum against FOXL2 protein, immunoexpression of FOXL2 was tested in 501 ovarian tumor samples, including 119 SCSTs, using whole tissue sections and tissue microarrays. " 10/01/2011 - "Patients with juvenile granulosa cell tumors and higher FOXL2 protein expression had worse overall survival and disease-free survival than those with negative or weakly immunoreactive tumors. " 10/01/2011 - "We also found that the mutated tumors had a higher immunohistochemical expression of the FOXL2 protein, and there was a linear correlation between mRNA and immunohistochemical FOXL2 expression in both adult and juvenile granulosa cell tumors. " 12/01/2012 - "We show that human gonadotroph cell pituitary tumors, unlike other secreting tumor types, express high levels of gonadotroph-specific forkhead transcription factor FOXL2, and both PTTG and Forkhead box protein L2 (FOXL2) stimulate gonadotroph clusterin (Clu) expression. "
4.	Granulosa Cell Tumor 10/01/2011 - "Patients with juvenile granulosa cell tumors and higher FOXL2 protein expression had worse overall survival and disease-free survival than those with negative or weakly immunoreactive tumors. " 07/01/2011 - "Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors." 06/05/2015 - "Identification and Validation of Differential Phosphorylation Sites of the Nuclear FOXL2 Protein as Potential Novel Biomarkers for Adult-Type Granulosa Cell Tumors." 10/01/2011 - "We also found that the mutated tumors had a higher immunohistochemical expression of the FOXL2 protein, and there was a linear correlation between mRNA and immunohistochemical FOXL2 expression in both adult and juvenile granulosa cell tumors. "
5.	Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor) 07/01/2011 - "Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors."

Related Drugs and Biologics

1.	Forkhead Transcription Factors (Forkhead Box Proteins)
2.	Bone Morphogenetic Protein 15
3.	Growth Differentiation Factor 9
4.	Clusterin
5.	Glutamic Acid (Glutamate)
6.	Biomarkers (Surrogate Marker)
7.	Steroids
8.	Messenger RNA (mRNA)
9.	Lysine (L-Lysine)
10.	Luteinizing Hormone (Lutropin)