Dysbindin

A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.

Also Known As:

Networked: 289 relevant articles (4 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hashimoto, Ryota: 18 articles (10/2014 - 06/2004)
2.	Talbot, Konrad: 13 articles (05/2017 - 05/2004)
3.	Takeda, Masatoshi: 12 articles (10/2014 - 08/2008)
4.	Faundez, Victor: 11 articles (01/2017 - 08/2011)
5.	Larimore, Jennifer: 9 articles (01/2017 - 08/2011)
6.	Weinberger, Daniel R: 9 articles (01/2016 - 06/2004)
7.	Blake, Derek J: 9 articles (03/2011 - 07/2003)
8.	Matsuzaki, Shinsuke: 8 articles (06/2015 - 06/2006)
9.	O'Donovan, Michael C: 8 articles (12/2011 - 05/2004)
10.	Owen, Michael J: 8 articles (04/2008 - 05/2004)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2017 - "We found that nuclear SREBP1 is dramatically reduced in dysbindin-1 knockout mice and postmortem brain tissues from human patients with schizophrenia. " 01/01/2021 - "In the present study, we hypothesized that there would be lower levels of dysbindin-1 and CTR1 in the hippocampus in schizophrenia versus a comparison group. " 12/01/2017 - "Our recent study showed that schizophrenia susceptibility factor dysbindin exhibited significant higher level in serum of PDAC patients. " 04/02/2012 - "Impairments in anatomic connectivity as found associated with the minor Dysbindin allele in our study may result in increased risk for schizophrenia due to altered fiber tracts." 04/02/2012 - "We here present a study on the effects of a Dysbindin schizophrenia susceptibility gene variant on fiber tract integrity in healthy young subjects. "
2.	Cognitive Dysfunction 01/01/2017 - "These results show promise for counteracting the cognitive impairments seen in neuropsychiatric disorders and may shed light on the role of dysbindin-1. " 10/01/2016 - "DTNBP1, which encodes dysbindin-1, is associated with cognitive impairment. " 11/01/2009 - "Dysbindin mutants showed impairments of spatial working memory compared with wild-type controls; heterozygous mice showed intermediate levels of cognitive dysfunction. " 04/01/2009 - "This paper reviews the research progress on the dysbindin gene in schizophrenia, including the dysbindin gene and its product, the possible pathogenic mechanisms, the association study of the dysbindin gene with schizophrenia, and the cognitive decline caused by the dysbind in variations." 01/01/2021 - "Dysbindin loss may lead to RRP replenishment dysregulation during high-frequency stimulation, potentially causing cognitive impairment in schizophrenia."
3.	Mood Disorders (Mood Disorder) 09/01/2006 - "Association of the dysbindin gene with bipolar affective disorder." 09/01/2006 - "The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. " 05/01/2011 - "In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia." 09/01/2006 - "Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. " 08/15/2004 - "In this context, the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1), which was recently reported to be associated with schizophrenia seems to be an interesting candidate gene for affective disorders. "
4.	Hypertrophy 10/31/2020 - "Interestingly, however, the levels of hypertrophy-inducing interaction partner Myozap as well as the BLOC-1 partners of Dysbindin like Muted and Pallidin were dramatically reduced in Dtnbp1_KO mouse hearts. " 10/31/2020 - "Taken together, our data suggest that Dysbindin's role in cardiomyocyte hypertrophy is redundant in vivo, yet essential to maintain the stability of its direct interaction partners like Myozap, Pallidin and Muted." 01/01/2017 - "In conclusion, we provide here a novel mechanism of post-translational regulation of dysbindin and hypertrophy via TRIM24 and TRIM32 and show the importance of TRIM32 in cardiomyocyte apoptosis in vitro." 01/01/2017 - "Correspondingly, TRIM32 attenuated the activation of SRF signaling and hypertrophy due to dysbindin, whereas TRIM24 promoted these effects in neonatal rat ventricular cardiomyocytes. " 11/25/2013 - "Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy."
5.	Bipolar Disorder (Manic Depressive Psychosis) 04/01/2005 - "Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)." 04/01/2011 - "The dysbindin-1 gene (DTNBP1) has been associated with schizophrenia and bipolar disorder diagnoses. " 01/18/2011 - "Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. " 09/05/2009 - "There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD). " 03/01/2007 - "Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder. "

Related Drugs and Biologics

1.	Neuregulin-1 (Neuregulin 1)
2.	Dysbindin
3.	Proteins (Proteins, Gene)
4.	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)
5.	Brain-Derived Neurotrophic Factor (BDNF)
6.	Neuregulins
7.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
8.	Messenger RNA (mRNA)
9.	Transferases
10.	catechol (pyrocatechol)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)